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  1. MarcNotMark

    Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

    Would it be a good idea to make this a more general thread, like a "breaking news" thread which is only sparingly used for important (hopefully positive) updates. Especially useful for members that have forum breaks and don't follow other social media so that no important news is missed.
  2. MarcNotMark

    Malic acid supplement, sumac

    I have been taking Magnesium Malate tablets (Source Naturals) a few periods, these are the ingredients: I don't remember noticing any difference if I took it or not. Taking one tablet per day in the morning that's of 833 mg Malic Acid. @jnmaciuch Would one tablet of this be the right...
  3. MarcNotMark

    Should we change our name: 'ME/CFS Skeptic'?

    ME/CFS Skrutiniser It's not in the English dictionary but at least you can keep the "sk" Alternatives: Scrutiniser / Skrutinizer / Scrutinizer Scrutiniser meaning: a careful examiner; someone who inspects with great care
  4. MarcNotMark

    Is there now a pattern over the year of Covid incidence (UK)?

    Here in the Netherlands the virus amount in the sewage water is measured, this is from the past few years. It seems generally weeks 18-22 (May) have the lowest concentrations, no guarantee for next year of course ;)
  5. MarcNotMark

    [Thought experiment] In a random cohort of 100 ME/CFS patients (recent diagnosis via CCC), what can you know about them with 90%+ certainty?

    I have not seen anything about taking blood samples. I know there's no diagnostic test but would it be possible to distinguish between a group of 100 pwME and a group of 100 HC from blood work alone? I mean with 90% certainty.
  6. MarcNotMark

    Poll: What is your most disabling symptom?

    Other poll about symptoms: https://www.s4me.info/threads/if-you-could-get-rid-of-two-of-your-me-cfs-symptoms-which-would-they-be.19187/
  7. MarcNotMark

    Intermittent fasting linked to higher risk of cardiovascular death, research suggests (NBC News Article)

    https://www.nbcnews.com/health/heart-health/intermittent-fasting-risk-cardiovascular-death-rcna143853 Intermittent fasting, a diet pattern that involves alternating between periods of fasting and eating, can lower blood pressure and help some people lose weight, past research has indicated...
  8. MarcNotMark

    Petition: The Netherlands: Vote for post-COVID outpatient clinics, closes 13/02/2024

    I see no restrictions, so I guess "yes" Fill in Name, mail address and place of residence (city). If you don't tick the box you sign the petition anonymous. After that you receive a mail where you can click on the confirm link, that's it. I see that the petition is offered to the House of...
  9. MarcNotMark

    Muscle abnormalities worsen after post-exertional malaise in long COVID, 2023/4, Wüst, van Vugt, Appelman et al

    van Vugt on National TV yesterday, unfortunately no translation in English: PS Shocked by all the comments under this tweet, about 90% by people blaming vaccins
  10. MarcNotMark

    Muscle abnormalities worsen after post-exertional malaise in long COVID, 2023/4, Wüst, van Vugt, Appelman et al

    Other thread about another publication by (some of) these researchers: https://www.s4me.info/threads/prolonged-indoleamine-2-3-dioxygenase-2-activity-and-associated-cellular-stress-in-post-acute-sequelae-of-sars-cov-2-infection-2023-guo-et-al.34402/
  11. MarcNotMark

    Measuring Cognitive Exertion

    I use a Garmin and they also link to "Firstbeat" What I noticed is that very often my stress levels are a lot higher during sleep compared to when I'm awake and resting. Sometimes this lasts the whole night and sometimes stress levels go down halfway the night after a bathroom break (it acts...
  12. MarcNotMark

    Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection, 2023, Guo et al

    News article put through Google Translate with some manual adaptions: https://nos.nl/artikel/2486149-experimenteel-kankermedicijn-in-beeld-als-antwoord-op-longcovidklachten Experimental cancer medicine in the picture as an answer to long covid complaints A new important step has been taken...
  13. MarcNotMark

    Butterfly symbol for ME/CFS

    Butterfly was even considered for this forum's logo, see this thread: https://www.s4me.info/threads/suggestion-create-a-logo.1691/
  14. MarcNotMark

    British Medical Association article: Long Covid - we've been here before, 2021, J. Trueland

    Well, there's this from Fluge and Mella (2014), using L-Arginine and L-Citrulline to increase NO. Not sure what became of this. https://data.epo.org/publication-server/pdf-document?pn=2805730&ki=A1&cc=EP&pd=20141126
  15. MarcNotMark

    FDA rejects Gilead's would-be blockbuster filgotinib over toxicity concerns

    Approval today in both Japan and Europe for Jyseleca / Filgotinib.
  16. MarcNotMark

    FDA rejects Gilead's would-be blockbuster filgotinib over toxicity concerns

    I saw this safety overview (comparison with JAK inhibitors {Edit:and Humira} already on the market) posted in another place (so I cannot guarantee it's 100% correct) so rejection was not expected. As for lower sperm count, this was observed in preclinical trials with very high doses on rats, not...
  17. MarcNotMark

    Question: Coronavirus & home sewn masks?

    Not to be taken too seriously this one I think but maybe it'll give you new ideas. Watch the grandma. .
  18. MarcNotMark

    The biology of coronavirus COVID-19 - including research and treatments

    Detect Covid-19 in as little as 5 minutes: https://www.abbott.com/corpnewsroom/product-and-innovation/detect-covid-19-in-as-little-as-5-minutes.html .
  19. MarcNotMark

    Coronavirus - worldwide spread and control

    Some statistics on the 213 Corona deaths in the Netherlands so far. At least half of corona deaths had an underlying condition, two thirds are men. https://nos.nl/artikel/2328082-zeker-helft-coronadoden-had-onderliggende-aandoening-twee-derde-is-man.html Google Translate: Also here the...
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