Search results

A really good point about the neurons.

Something that's been on my mind is how a trapped cell would be passed down during mitosis? Would the daughter cells inherit this problem? As we all know.. cells die and new ones are made. But.. me/cfs does not improve with time. Is anyone here techie enough to explain why the metabolic trap...

I had the worst crash of my life when on prednisolone. But!!! I was also prescribed an extremely high dose of calcium supplementation while on them. I also received sleeping meds due to insomnia as a side effect. So I can't say it was the steroid. btw. I'm happy you've had some relief.

Interesting.. I did read that TPH2 was statistically significant in development of ME/CFS. TPH1/TPH2 is responsible for || Trypophan + TPH1/TPH2 --> 5-HTP --> Serotonin || Dr Phair's paper did suggest that TPH1 is also substrate inhibited, like IDO1. "This is because TPH1 is, itself...

"The draft guidelines were predicted to stop the use of GET and limit the use of CBT which have served most chronic fatigue syndrome/ME clinicians and patients well for many years" I'm gutted to hear that individuals like him still have the power to stop institutions in their tracks. And...

Merged thread Coronavirus: Twelve weeks on I can't kick Covid exhaustion Little do people know, that this 12 weeks could turn into 12 years.... and the rest. https://www.bbc.co.uk/news/uk-scotland-north-east-orkney-shetland-53056785

My guess is that they are supplementing it based on the theory that kynurenine would be low in patients if Dr Phair's IDO2 metabolic trap hypothesis is correct.

I think it's fair to say that funding tends to correlate with disease mortality rates.

I think it's very important that researchers are careful about who they use to sample. They have to be 100% certain they have the disease.. especially with diseases which are not diagnosed using biological tests, such as ME or mental health problems. I agree, the Biobank's data will be wrong...

It's an interesting idea and I heard Ron Davies talking about this. There are alot of patients who are fed by tube or w.e as they're too sick to consume normal food. When they came to testing the microbiome, there wasnt one.. If the microbiome is at the root of the disease, then it is...

I had a gadolinium contrast for an MRI in about... 2014 (ish). I instantly had an allergic reaction and they had to abandon the test and take me through to some other place in hospital. I was unsure about it before they injected me but they reassured me that it was safe and its negative effects...

Yeah, looks that way. I thought the below comment was quite vocal. "After a diagnosis of CFS/ME is made using the MES test, patients are subsequently sold supplements in order to treat their CFS/ME, despite there being no placebo-controlled trial to show their effectiveness. The first...

I'm being pedantic but the title "Can you reshape your brain's response to pain?" doesn't make sense. The brain doesn't respond to pain, it creates it.

All patients that Robert Phair examined had either a damaging mutiation in IDO2 (typtophan pathway) or tyrosine hydroxylase (tyrosine pathway). Tyrosine hydroxylase is enzyme that catabolizes L-tyronise into L-DOPA, which then goes on to become Dopamine etc. The facinating discovery behind...

Yes!! that and some crutches. :thumbup:

I'm unsure if there is an official criteria but I found this definition: With the current evidence for ME/CFS, I can see the justification to call it a syndrome. However, It wouldn't surprise me if it turned out to be a disease with real pathophysiological causes. Who knows, the name might...

Not sure if it's been shared or seen by any of you, but Ron Davis has summarized where they are, regarding the topic of this thread.

Well done to all and a massive thanks to those that donated.

Definitely not. Some things are just worth it. :emoji_sweat_smile::emoji_sweat_smile:

Simon Wessely, a psychiatrist at King’s College London’s Institute of Psychiatry, said "The (first) issue is, can any biomarker distinguish CFS patients from those with other fatiguing illnesses? And second, is it measuring the cause, and not the consequence, of illness?” First of all...