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  1. Sean

    Enduring symptoms: A call to immediate action, 2025, Barnes

    Funding these clinics not only wastes money, but causes considerable harm by maintaining the fiction that there are effective treatments available to those patients who really want to be well. And strongly implies, their claims to the contrary notwithstanding, their preferred psycho-behavioural...
  2. Sean

    Characterization of Post-Viral Infection Behaviors […]: Prospective, Observational, Longitudinal Cohort Analyses of Fitbit [& PROs], 2025,Zhang,Unger+

    Our finding that a lower MVPA [moderate-vigorous physical activity] level was associated with more improvements in outcomes in the long-term seems to suggest some benefit from reduced activity. As we have been saying for [checks notes] effing decades. And the earlier patients can implement...
  3. Sean

    Review Comparative efficacy of various exercise therapies for chronic fatigue syndrome: A systematic review and network meta-analysis, 2025, Liao et al.

    We are in the era of just making shit up, where methodological standards are whatever you want them to be.
  4. Sean

    Impact of Prior History of Traumatic Stress on Autonomic and Multi-System Symptoms Following COVID-19 Infection, 2025, Hendrickson et al

    Design Observational, self-report, single time-point online assessment. Stopped there. Saved time.
  5. Sean

    Trial Report Clinical Improvements Following a Non-Aerobic Therapeutic Exercise in Women with Long COVID, 2025, Miana et al

    Repeating a previous statement or claim, just with different wording, is something that AI generated text frequently does. -------- Participants engaged in a therapeutic exercise program designed to promote correct body alignment and optimal biomechanics And the evidence for patients having...
  6. Sean

    2025: looking back on a year of ME/CFS research

    Negative (null) results are just as important as positive results. The only important questions about a study are 1) is it relevant, and 2) is it well conducted. I would write 250.000 as 250 000. Positive results have a comparable problem if they are false, which they sometimes are. The story...
  7. Sean

    UK: Physios for ME

    And, of course, requires the instruction and oversight by a 'professional expert' to achieve. It just continues the long discredited and very destructive assumption that patients don't know their own body and its limitations, but by some miracle, against all evidence and logic, the experts do...
  8. Sean

    Why is showering so PEM/OI inducing

    Interesting. I tend to move about a bit in the shower, changing from one foot to the other, turning around frequently, etc. Maybe that is an unconscious learned thing to dynamically maintain balance and blood flow.
  9. Sean

    Does symptom perception after negative affect induction differ between physically ill and healthy individuals? ... 2026 Jessen et al

    Symptom perception is highly subjective and shaped by complex biopsychosocial factors. Always good to start with your conclusion. :rolleyes:
  10. Sean

    Why is showering so PEM/OI inducing

    Showers have a price. I often lie down for a bit after one, depending on various factors. OTOH, a hot shower is very good for soothing sore muscles and stimulating blood flow.
  11. Sean

    Fred Rossi - Writings related to ME/CFS

    Good article. Thank you, Fred Rossi.
  12. Sean

    Proxy Praxis: How Surrogate Endpoints Can Speed Drug Development

    Yes, what about relevance, safety, and conflicts of interest?
  13. Sean

    Preprint Distinct Symptom Clusters Reflect Pathophysiological Mechanisms in ME/CFS, 2025, Habermann-Horstmeier et al

    And this, ladies and gentlemen, is why relying on superficial correlations is so dangerous.
  14. Sean

    Hypotheses and Research Directions for ME/CFS

    Any hypothesis must explain the delayed component of PEM. It is a distinct and core feature, and the main clue, I think. It is not fatigue, tiredness, deconditioning, DOMS, etc. It is something different to all those.
  15. Sean

    USA: News from Solve ME

    So what that tells me is, ME/CFS is not a single disease, but it is a disease with different biological subtypes. Maybe. Cancer has a wide range of forms, symptoms and signs, and causes (genetic, chemical, infectious, radiological), and different treatments. But all cancers have one thing in...
  16. Sean

    Healthcare use and costs of functional somatic disorder in Denmark: a population-based cohort study (DanFunD) 2025 Petersen, Fink et al

    Functional somatic disorder (FSD) is a common condition characterised by persistent patterns of physical symptoms that cannot be better explained by other physical or mental conditions. Unless there is a translation issue, then this is a disingenuous rhetorical sleight-of-hand. They are not...
  17. Sean

    ‘There’s nothing wrong with you’: The making of disability through encounters in accessible parking spaces, 2025,Kubenz

    I qualify for a disabled parking permit, but have not taken it up for exactly these reasons. Not going to add another layer of abuse to what I already have to deal with. In a practical sense it doesn't make much difference, for various reasons. But there are occasions when I could benefit from...
  18. Sean

    Do we need a long-term actimeter study of PwME outside of treatment?

    I agree, as long as there are good records of what the patients do so it can be factored in. Should help reveal what helps and what doesn't, among other things. The key is having a large sample size, and doing it for long enough.
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