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Would premature endothelial senescence increase risk of cardiovascular events, particularly long-term?

Not my understanding of it. I take it to mean matching activity levels to current symptom levels. Which may or may not be a steady rate, depending on how stable and predictable symptoms are. For at least many patients, particularly early on when first learning how to apply pacing, they are...

ABSTRACT, with added spacing. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are two post-viral diseases, which share many common symptoms and pathophysiological alterations. Yet a mechanistic explanation of disease induction and maintenance is lacking. This hinders...

Yep. It seems to have made little if any practical difference at all.

So, it is in nobody’s interest to accept this as a real condition. Besides patients. And their family. And friends. And community. And the national budget. The bit I don't get in all this idiocy is just how short-sighted burying heads in the sand is. The best, and indeed only way, to solve...

Indeed. You can always add more layers of clothing or blankets in cold weather (within reason). But you quickly run out of clothes to shed in hot weather. Hence air-conditioners.

Cherry picking, both the 'evidence' and the interpretation, par excellence. Until they start getting held to adequate account for it they will continue right with this appalling dishonesty and expanding their empire. No sign of that accountability happening yet. To the contrary. They are being...

The lack of a no-intervention control group restricts causal attribution. It does not allow it at all. Yes, yes, and yes.

Did they control for financial & housing stress, and being subject to endless arbitrary psycho-drama and morality play soaked impositions, for example, and try relieving that? Start with the basics first. This.

Yep. Just psych-washing.

What about selection criteria? In particular, are they differentiating properly for PEM? I suspect that failure to do that is the main means by which these LC exercise studies are getting away with this stuff.

When contextualized within prior research, our SSD estimates appear plausible. The methodological circle jerk continues right on, unrestrained by reality.

underscoring the ongoing importance of prevention measures. Good luck with that in current socio-political and medical climate.

there is no clear evidence base So, once again, they are brazenly admitting they got nothing, besides their nakedly self-serving clinical 'feels', yet are continuing to expand their empire anyway? Can somebody please explain how this is not straight fraud and corruption. And very very cruel to...

accompanied by excessive According to...?

negotiating an agreed approach This is insanity. As meaningless and pointless as negotiating with the sun about its size, but infinitely more destructive and cruel.

science of predictive processing News to me. If you are living with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or long COVID, you’ve likely learned to be very careful about not overdoing it. After meticulous efforts not to exceed your "energy envelope", you may have achieved...

Psychosomatics is by far the greatest failure and disaster of modern medicine. How it has become so dominant and immune to legit criticism is a damning indictment of the profession's technical and ethical standards, and the rest of the governance system for allowing to get so far and become such...

emphasizing the need for tailored support and ongoing resources to facilitate sustained recovery. Or for admitting that you are barking up the wrong tree.

Functional neurological disorders (FNDs) are neurological conditions resulting from altered brain network activity... FND results from abnormal connectivity in the limbic system and overlapping circuitry dysfunction in salience networks. Is there actually any hard evidence for this 'explanation'?