2021

Background: Persistent physical symptoms are common after a coronavirus disease 2019 (COVID-19) episode, but their pathophysiological mechanisms remain poorly understood. In this study, we aimed to explore the association between anxiety and depression at 1-month after acute infection and the...

ABSTRACT Introduction Chronic fatigue syndrome (CFS), also known as chronic fatigue and immune dysfunction syndrome, has become a common disease in modern medicine. Objective The paper analyzes the impact of exercise training on patients' quality of life with chronic fatigue syndrome. Methods...

Excerpts from the letter: Nowadays, there are several recommendations/guidelines related to the management of long COVID-19 patient [6–10]. These guidelines target the specialist physicians, mainly pulmonologists [6], cardiologists [8], physical medicine and rehabilitation specialists [7], or a...

The impact of viral infections on the brain has been long studied in the context of rabies, herpes simplex, HIV, measles, and a few other viruses that target the organ directly, but little has been known about indirect effects of viral infections. This specific research has been boosted though...

Highlights Experiential knowledge can fill crucial gaps in the pandemic discourse. Long COVID online self-advocacy provides a rich source of subjective evidence. Patient subjective evidence is challenging the normative role of clinical evidence. Activism made long COVID diagnosis as a...

Abstract Long-term sequel of acute COVID-19, commonly referred to as long COVID, has affected millions of patients worldwide. Long COVID patients display persistent or relapsing and remitting symptoms that include fatigue, breathlessness, cough, myalgia, arthralgia, sleep disturbance, cognitive...

Orthostatic intolerance syndromes after hematopoietic cell transplantation: clinical characteristics and therapeutic interventions in a single-center experience Abstract Background Hematopoietic cell transplantation (HCT) is an established and potentially curative therapeutic option for...

Abstract Background: Prior studies have demonstrated that Lyme disease is frequently over-diagnosed. However, few studies describe which conditions are misdiagnosed as Lyme disease. Methods: This retrospective observational cohort study evaluated patients referred for Lyme disease to a...

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Preventing progression from chronic to widespread pain and its impact on health-related quality of life: a historical cohort study of osteopathic medical care Abstract Context It is generally acknowledged that osteopathic physicians take a holistic approach to patient care. This style may help...

Recruitment characteristics and non-adherence associated factors of fibromyalgia patients in a randomized clinical trial: A retrospective survival analysis Abstract Introduction Fibromyalgia is a complex pain condition that affects mostly women. Given the disease's lack of understanding...

Abstract There is a small yet robust body of literature regarding autonomic dysfunction in Idiopathic hypersomnia (IH) as well as sleep disturbances in Postural Orthostatic Tachycardia Syndrome (POTS). This review aims at summarizing the current literature and highlighting gaps in the current...

In mice. Highlights Altered metabolic features of microglia in the absence of host microbiota Bacteria-derived acetate modulates metabolic features of microglia during steady state Acetate regulates microglial functions during neurodegeneration Summary As tissue macrophages of the central...

The illness-disease dichotomy and the biological-clinical splitting of medicine Tesio and Buzzoni 2021 Abstract In a recent paper, Sharpe and Greco (2019) argue that some clinical conditions, such as chronic fatigue syndrome (sometimes called myalgic encephalomyelitis), should be treated by...

Full title: Cardiovascular risk assessment using ASCVD risk score in fibromyalgia: a single-centre, retrospective study using "traditional" case control methodology and "novel" machine learning. Abstract Background In autoimmune inflammatory rheumatological diseases, routine cardiovascular risk...

ABSTRACT Background Fibromyalgia (FM) is associated with sexual dysfunction, though much less is known about the sexual desire, and especially dyadic and solitary sexual desire, among women with fibromyalgia. Aim To investigate on the one hand the global sexual desire, the dyadic sexual and...

Abstract Objectives The authors used cardiopulmonary exercise testing (CPET) to define unexplained dyspnea in patients with post-acute sequelae of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection (PASC). We assessed participants for criteria to diagnose myalgic...

Full title: Virtual Reality-Based Therapy Reduces the Disabling Impact of Fibromyalgia Syndrome in Women: Systematic Review with Meta-Analysis of Randomized Controlled Trials. Abstract Background: Virtual reality-based therapy (VRBT) is a novel therapeutic approach to be used in women with...

Abstract Despite the growing number of patients with persistent symptoms after acute SARS-CoV-2 infection, the pathophysiology underlying long-COVID is not yet well characterized, and there is no established therapy. We performed a deep immune profiling in nine patients with persistent symptoms...

Opinion piece in the BMJ Conclusion Going forward, we recommend: Acknowledging that patients with long term conditions may experience challenging forms of “identity loss” which may lead them to feel more vulnerable. Addressing stigma in healthcare as well as in communities and workplaces...