ageing

From HIV to SARS-CoV-2 associated neurological disorder (“HAND” to “SAND”): Viral infection as a “time-bomb“ for the aging brain Millan, Mark J. Highlights SARS-CoV-2 infections frequently trigger a delayed, multi-organ syndrome called Long Covid. A subset of symptoms, including cognitive...

Host–virus resilience networks and viral inflammaging circuits in aging and long COVID: a CMV-centered perspective Müller, Ludmila; Di Benedetto, Svetlana; Müller, Viktor Abstract Aging and long COVID are increasingly recognized as states of disrupted host homeostasis characterized by chronic...

Frailty: An overview Journal of Family Medicine and Primary Care, 15(1): p 39-44, January 2026. DOI: 10.4103/jfmpc.jfmpc_1748_25 Abstract Frailty is an emerging global health concern driven by population aging and rising prevalence of multimorbidity. It is a multidimensional geriatric...

Platelet factors attenuate inflammation and rescue cognition in ageing Schroer, Adam B.; Ventura, Patrick B.; Sucharov, Juliana; Misra, Rhea; Chui, M. K. Kirsten; Bieri, Gregor; Horowitz, Alana M.; Smith, Lucas K.; Encabo, Katriel; Tenggara, Imelda; Couthouis, Julien; Gross, Joshua D.; Chan...

Abstract Healthy skeletal muscle can regenerate after ischaemic, mechanical, or toxin-induced injury, but ageing impairs that regeneration potential. This has been largely attributed to dysfunctional satellite cells and reduced myogenic capacity. Understanding which signalling pathways are...

Abstract Age is associated with progressively impaired, metabolic, cardiac and vascular function, as well as reduced work/exercise capacity, mobility, and hence quality of life. Exercise exhibit positive effects on age-related dysfunctions and diseases. However, for a variety of reasons many...

This is a really good article about the research they are doing. It's about old age, but I think many here would recognize a lot of it. https://theconversation.com/loneliness-loss-and-regret-what-getting-old-really-feels-like-new-study-157731?utm_source=twitter&utm_medium=bylinetwitterbutton

makes a change from mice I suppose! Did think about posting it in the Cat thread. https://www.findaphd.com/phds/project/characterisation-of-clinical-biochemical-and-metabolomic-biomarkers-in-cats-during-the-ageing-process/?p129618

https://www.nature.com/articles/s41586-020-03160-0

https://www.pnas.org/content/117/11/6170.long The Guardian: Low-carb diet may reverse age-related brain deterioration, study finds

https://www.sciencedirect.com/science/article/abs/pii/S0531556520305258?dgcid=rss_sd_all

https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-020-01887-1

https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1 Preprint twitter thread here

Sounds too good to be true.

I wondered what people on here made of this latest bit of research reported today on the BBC. https://www.bbc.co.uk/news/health-50015982 I can't see that anyone else has posted this, but I may be wrong? Apologies if this is posted on another thread somewhere. Here is another link as I now see...

https://www.sciencedaily.com/releases/2019/08/190814130726.htm https://www.nature.com/articles/s41586-019-1484-9 Unstiffen my OPC microenvironment, please.

Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk Anthony S. Zannas,a,b,c,d,1 Meiwen Jia,a Kathrin Hafner,a Jens Baumert,e Tobias Wiechmann,a Julius C. Pape,a Janine Arloth,a,f Maik Ködel,a Silvia Martinelli,a Maria Roitman,a...

https://www.ncbi.nlm.nih.gov/pubmed/31083530 https://www.mdpi.com/2079-7737/8/2/27/htm This research is not explicitly about ME/CFS but I decided to put it here anyway because it's about CDR and because of the acknowledgements in the full paper:

Chemicals 'repair damaged neurons in mice' http://www.bbc.co.uk/news/science-environment-47234787 2 studies on mice First is on leaky brain barrier and inflammation

Given the recent coverage from the INF-a study, I thought this article on a similar topic was interesting: https://www.healtheuropa.eu/hyperactive-immune-system-ageing-brain-disorders/89599/