animal model

https://www.nature.com/articles/s41467-025-57905-4 Abstract The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 has highlighted the vulnerability of a globally connected population to zoonotic viruses. The FDA-approved coronavirus antiviral Paxlovid targets the essential SARS-CoV-2 main...

Effect of Deep Tissue Incision on pH Responses of Afferent Fibers and Dorsal Root Ganglia Innervating Muscle Kanta Kido, D.D.S., Ph.D.; Mamta Gautam, Ph.D.; Christopher J. Benson, M.D.; He Gu, M.D., Ph.D.; Timothy J. Brennan, M.D., Ph.D. Anesthesiology November 2013, Vol. 119, 1186–1197...

Dr. Walter Tarello Gatekeeper Press, 5 Sept 2024 - Health & Fitness - 356 pages Chronic Fatigue is the authentic, fascinating and riveting account of the author’s journey in the ‘heart of darkness’ of modern medicine, the Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis...

Transfer of human serum IgG to nonobese diabetic Igμnull mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjögren’s syndrome - link Christopher P. Robinson,* Jason Brayer,* Shigeo Yamachika,* Thomas R. Esch,† Ammon B. Peck,‡§Carol A. Stewart,§¶...

Immune Correlates of Hyperglycemia and Vaccination in a Non-human Primate Model of Long-COVID Abstract Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are major manifestations of the post-acute sequelae of SARS-CoV-2 (PASC). Our understanding of lasting...

Functional characterisation of the ACE2 orthologues in Drosophila provides insights into the neuromuscular complications of COVID-19 Highlights A large percentage of patients with COVID-19 have neuromuscular manifestations. Loss of Drosophila ACE2 orthologues Ance or Ance3 impaired motoric...

[Rats were tortured to simulate 'CFS', then were given transcutaneous electrical acupoint stimulation, improved "learning and memory ability of CFS rats" was then claimed] Objective: To observe the effect of transcutaneous electrical acupoint stimulation (TEAS) on the histomorphological...

Full title: Effect of herbal cake-separated moxibustion on behavioral stress reactions and blood lactic acid level and muscular AMPK/PGC-1α signaling in rats with CFS Objective: To observe the effect of herbal cake-separated moxibustion (HCSM) on serum lactic acid (BLA) level and AMPK/PGC-1α...

A discussion has arisen on the use of animals in biological research into ME. I suspect there is insufficient data to create animal models of ME at the moment, but that may change in the future, for example using mice to test hypotheseis on potential causes of ME. Medical research into...

Abstract The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in prolonged pathologies collectively referred to as post-acute sequalae of COVID-19 (PASC) or long COVID. To better understand the mechanism underlying long COVID biology, we...

[This seems to be only very tenuously about ME/CFS] Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease of unknown etiology and without effective treatment options. The onset of ME/CFS is often associated with neuroinflammation following bacterial or...

Gut microbiota from patients with mild COVID-19 cause alterations in mice that resemble post-COVID syndrome Viviani Mendes de Almeida, Daiane F Engel, Mayra Fernanda Ricci, Clênio Silva Cruz, Icaro Santos Lopes, Daniele Almeida Alves, Mirna d’ Auriol, João Magalhães, Giuliana S. Zuccoli, Bradley...

SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations post recovery Justin J. Frere, Randal A. Serafini, Kerri D. Pryce, Marianna Zazhytska, Kohei Oishi, Ilona Golynker, Maryline Panis, Jeffrey Zimering, Shu Horiuchi, Daisy A. Hoagland, Rasmus Møller...

Abstract Chronic fatigue syndrome (CFS) has a high incidence due to the increased pressure of daily life and work in modern society. Our previous clinical studies have found the effects of electroacupuncture (EA) on CFS patients, however, the mechanism of EA on CFS is still unknown. In this...

Abstract Post-acute sequelae of COVID-19, commonly known as long-COVID, is defined as a persistent symptom(s) that is unexplainable by alternative diagnosis and lasts beyond three months after the onset of COVID-19. Several studies have now identified long-COVID in >50% of COVID-19 patients...

Is there a thread about this already? Someone just mentioned this to me - https://www.healthline.com/health/shilajit#benefits " 3. Chronic fatigue syndrome Chronic fatigue syndrome (CFS) is a long-term condition that causes extreme tiredness or fatigue. CFS can make it difficult to go to work...

Abstract Neurological manifestations are a significant complication of coronavirus disease (COVID-19), but underlying mechanisms aren’t well understood. The development of animal models that recapitulate the neuropathological findings of autopsied brain tissue from patients who died from...

Abstract Danggui Buxue Tang (DBT), a traditional Chinese medicine formula for “invigorating qi and enriching blood”, has been reported to produce a good effect on chronic fatigue syndrome (CFS). However, the related mechanism remains largely unresolved. In this study, a metabolomics approach...

Abstract Purpose Previous studies demonstrated M2 muscarinic acetylcholine receptor-activating autoantibodies (M2R-AAb) were present in some patients with postural tachycardia syndrome (POTS). This study examines how these autoantibodies might contribute to the pathophysiology of POTS, and...

I wanted to donate to research which does not use non-human animals, so emailed ME Research UK to ask whether they did. They replied with a link to this page (indirectly) https://www.meresearch.org.uk/wp-content/uploads/2021/07/Standard-Grant-Conditions-2021.pdf which says "ME Research UK will...