Mapping microglia and astrocyte activation in vivo using diffusion MRI
Raquel Garcia-Hernandez, Antonio Cerdán Cerdá, Alejandro Trouve Carpena, Mark Drakesmith, Kristin Koller, Derek K Jones, Santiago Canals, Silvia De Santis
While glia are increasingly implicated in the pathophysiology of...
https://osf.io/ef3n4/
The newsbrief posting reminded me that this paper wasn't mentioned. I think it may be a pretty important hypothesis for ME's root cause. It fits what I believe is the root cause of ME: that neuroglia are involved. I'm not sure whether there are any ME symptoms that...
Abstract:
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that have important homeostatic and disease-promoting functions1. However, little is known about the homeostatic anti-inflammatory activities of astrocytes and their regulation. Here, using...
An interesting read given the past TSPO-PET neuroinflammation studies on ME using first generation [11C]PK-11195 and now more recently second generation [11C]DPA-713, the pros/cons and limitations of these radioligands, and the development of novel third generation ligands.
Recent Developments...
Possibly relevant to ME given the potential involvement of both microglia in the brain and the microbiome in the illness.
The article, https://medicalxpress.com/news/2018-05-gut-neurologic-disease.amp
https://www.nature.com/articles/s41586-018-0119-x
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