atp

Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response Serena Fineschi, Joakim Klar, Juan Ramon Lopez Egido, Jens Schuster, Jonas Bergquist...

Science. (Accepted): Running a genetic stop sign accelerates oxygen metabolism and energy production in horses Castiglione, GM, Chen, X., Xu, Z., Dbouk, N.H., Bose, A., Carmona-Berrio, D., Chi, E.E., Zhou, L., Boronina, T.N., Cole, R.N., Wu, S., Liu, A., Liu, T., Lu, H., Kalbfleisch, T., Rinker...

Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Abu Mohammad Syed; Alexander K. Karius; Jin Ma; Ping-yuan Wang; Paul M. Hwang ME/CFS is a debilitating multisystem disorder of unclear etiology that affects many individuals worldwide. One of its hallmark symptoms...

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5131664 Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disorder with no known underlying mechanisms, diagnostic tools, or treatments. Multiple areas of dysfunction have been extensively studied, but rarely...

The metabolic and physiologic impairments underlying long COVID associated exercise intolerance Brooks P. Leitner; Phillip Joseph; Andres Figueroa Quast; Maria Alejandra Ramirez; Paul M. Heerdt; Jose G. Villalobos; Inderjit Singh Data from invasive CPET (iCPET) revealed long COVID patients have...

Cellular ATP demand creates metabolically distinct subpopulations of mitochondria Ryu, Keun Woo; Fung, Tak Shun; Baker, Daphne C.; Saoi, Michelle; Park, Jinsung; Febres-Aldana, Christopher A.; Aly, Rania G.; Cui, Ruobing; Sharma, Anurag; Fu, Yi; Jones, Olivia L.; Cai, Xin; Pasolli, H. Amalia...

Abstract Background This study investigates the impact of fluctuating lipid levels on endothelial dysfunction. Methods Human aortic and umbilical vein endothelial cells were cultured under varying palmitic acid (PA) concentrations: 0, 50, and 100 μM, and in a variability group alternating...

Targeting the High-Density Lipoprotein Proteome for the Treatment of Post-Acute Sequelae of SARS-CoV-2 Grote, Karsten; Schaefer, Ann-Christin; Soufi, Muhidien; Ruppert, Volker; Linne, Uwe; Mukund Bhagwat, Aditya; Szymanski, Witold; Graumann, Johannes; Gercke, Yana; Aldudak, Sümeya...

Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder Lingampelly, Sai Sachin; Naviaux, Jane C.; Heuer, Luke S.; Monk, Jonathan M.; Li, Kefeng; Wang, Lin; Haapanen, Lori; Kelland, Chelsea A.; Van de Water, Judy; Naviaux, Robert K. Classical...

Red Blood Cell Adenylate Energetics Is Related to Endothelial and Microvascular Function in Long COVID Romanowska-Kocejko, Marzena; Jędrzejewska, Agata; Braczko, Alicja; Stawarska, Klaudia; Król, Oliwia; Frańczak, Marika; Harasim, Gabriela; Smoleński, Ryszard T.; Hellmann, Marcin; Kutryb-Zając...

Indole-3-propionic Acid, a Gut Microbiota-Derived Tryptophan Metabolite, Promotes Endothelial Dysfunction Impairing Purinergic-Induced Nitric Oxide Release in Endothelial Cells Geddo, Federica; Antoniotti, Susanna; Gallo, Maria Pia; Querio, Giulia Different gut microbiota-derived metabolites...

Altered mitochondrial respiration in peripheral blood mononuclear cells of post-acute sequelae of SARS-CoV-2 infection Dirajlal-Fargo; Maison; Durieux; Andrukhiv; Funderburg; Ailstock; Gerschenson; Mccomsey Peripheral blood mononuclear cells (PBMC) mitochondrial respiration was measured ex vivo...

https://www.nature.com/articles/s41598-020-61381-9#Fig1 Doxycycline has anti-tumour effects in a range of tumour systems. The aims of this study were to define the role mitochondria play in this process and examine the potential of doxycycline in combination with gemcitabine. We studied the...

Abstract The objectives of this study are to test the hypothesis that the fatigue and accompanying symptoms of Chronic Myalgic Encephalomyelitis/Fatigue Syndrome are in part due to defects in energy provision at the cellular level, and to understand the pathophysiology of the defects so that...

Abstract Adenosine triphosphate (ATP) at millimolar levels has recently been implicated in the solubilization of cellular proteins. However, the significance of this high ATP level under physiological conditions and the mechanisms that maintain ATP remain unclear. We herein demonstrated that...

"Reneo is a clinical stage pharmaceutical company focused on the development and commercialization of therapies for patients with rare genetic mitochondrial diseases, which are often associated with the inability of mitochondria to produce adenosine triphosphate (ATP). Reneo is developing REN001...

The capability to ferment sugars into ethanol is a key metabolic trait of yeasts. Crabtree-positive yeasts use fermentation even in the presence of oxygen, where they could, in principle, rely on the respiration pathway. This is surprising because fermentation has a much lower ATP yield than...

Abstract The nervous system displays high energy consumption, apparently not fulfilled by mitochondria, which are underrepresented therein. The oxidative phosphorylation (OxPhos) activity, a mitochondrial process that aerobically provides ATP, has also been reported also in the myelin sheath...

biomolecules: Bioenergetic and Proteomic Profiling of Immune Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients: An Exploratory Study Fernandes-Guerra et al Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a heterogeneous, debilitating, and complex...

Hypoxanthine (Hx), an intermediate metabolite of the purine metabolism pathway which is dramatically increased in blood and skeletal muscle during muscle contraction and metabolism, is characterized as a marker of exercise exhaustion. However, the physiological effects of Hx on skeletal muscle...