cd4+

Metabolic reprogramming of pathogenic CD4+ T helper cells attenuates inflammatory bowel disease in mice Shravan K Mishra; Leena M Abdelrahman; Hyun Se Kim Lee; Lucía Valenzuela-Pérez; Dina F Manna; Tanner J Abram; Lama Mohamed Ali; Heidi M Davidson; Omar M Hassan; William A FaubionJr; Petra...

Single-cell multi-omics show disruption of blood and airway T cells in pulmonary long COVID Abstract Background Approximately 10% of individuals who recover from COVID-19 experience residual respiratory symptoms impacting their quality of life, but the mechanisms behind pulmonary long COVID...

Intestinal infections establish antigen-specific, long-lived memory CD4+ T cells in the brain and meninges Abstract The meninges form the border between the brain and periphery and house a rich network of immune cells. Here we show that gastrointestinal challenges (intracellular or...

Prolactin modulates the naive B cell repertoire Abstract Prolactin is a peptide hormone produced by the anterior pituitary gland that is critical in lactation. Prolactin can also be produced by lymphocytes, and both B and T cells express prolactin receptors. These findings have suggested that...

Antigen presentation by CD40+MHC-II+ astrocytes promotes CNS autoimmunity Abstract Astrocytes contribute to the pathology of multiple neurological disorders, including the T cell-driven autoimmune disease of the central nervous system (CNS) multiple sclerosis and its mouse model, experimental...

CD4 + T cells reactive to Epstein-Barr virus late lytic antigens are enriched in individuals with multiple sclerosis Editor’s summary Epstein-Barr virus (EBV) has been nearly definitively linked to development of multiple sclerosis (MS); however, the exact roles of EBV itself and the immune...

CD4+ T cell signature in long COVID: insights from an unvaccinated cohort Abstract Objective: The pathogenesis of Long COVID (LC) remains poorly understood, with the analysis of immune responses often obscured by variables such as vaccination and reinfection. This study aimed to determine...

Identification of novel genes regulated by IL-12, IL-4, or TGF-beta during the early polarization of CD4+ lymphocytes Riikka Lund, Tero Aittokallio, Olli Nevalainen, Riitta Lahesmaa Abstract Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and...

Multi-layered deep immune profiling, SARS-CoV-2 RNAemia and inflammation in unvaccinated COVID-19 individuals with persistent symptoms Roberta Rovito, Valeria Bono, Nicolò Coianiz, Valentina Cazzetta, Sara Franzese, Joanna Mikulak, Clara Di Vito, Francesca Bai, Guillaume Beaudoin-Bussières...

Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Ekua W Brenu, Mieke L van Driel, Don R Staines, Kevin J Ashton, Sandra B Ramos, James Keane, Nancy G Klimas & Sonya M Marshall-Gradisnik Published: 28 May 2011 Background Chronic Fatigue...

Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis Sai Zhang; Fereshteh Jahanbani; Varuna Chander; Martin Kjellberg; Menghui Liu; Katherine Glass; David Iu; Faraz Ahmed; Han Li; Rajan Douglas Maynard; Tristan Chou...

SARS-CoV-2 post-acute sequelae linked to inflammation via extracellular vesicles Sara Bachiller, Joana Vitalle, Lluís Camprubí-Ferrer, Manuel García, Isabel Gallego, Marina López-García, María Isabel Galvá, Julio Cañizares, Inmaculada Rivas-Jeremías, María Díaz-Mateos, Carmen Gasca-Capote...

Clinical, histopathological, and radiological characterization of post-acute sequelae of COVID-19 Anna Czech Abstract Numerous patients exhibit enduring symptoms following a Coronavirus Disease 2019 (COVID-19) infection, termed Post-Acute Sequelae of COVID-19 (PASC). The typical manifestations...

Abstract: The ability of cells to maintain distinct identities and respond to transient environmental signals requires tightly controlled regulation of gene networks1,2,3. These dynamic regulatory circuits that respond to extracellular cues in primary human cells remain poorly defined. The...

n=31 Improvement of immune dysregulation in individuals with long COVID at 24-months following SARS-CoV-2 infection Abstract This study investigates the humoral and cellular immune responses and health-related quality of life measures in individuals with mild to moderate long COVID (LC)...