covid

Converging pathomechanisms link SARS-CoV-2 infection with major neurodegenerative diseases Abstract Neurological complications are among typical clinical manifestations, both during the acute phase of SARS-CoV-2 infection and long-term post-acute COVID-19 sequelae, i.e., Long COVID. A...

Fear of COVID-19 and PTSD symptoms in adolescents: the mediating role of meaning in life and the moderating role of gender Abstract Background: The COVID-19 pandemic and related restrictions were associated with substantial mental health burdens among adolescents, including PTSD symptoms...

Computational Analysis of Immunohistochemistry Enables Quantitative Assessment of SARS-CoV-2 Nucleocapsid Immunolabeling in Experimentally Infected Mice Abstract Histopathology and immunohistochemistry (IHC) are central to COVID-19 tissue evaluation. However, conventional manual scoring is...

Cerebrospinal fluid positive for SARS-CoV-2 associated with neurological manifestations and proteome alterations in a multiple myeloma patient Abstract Abstract Background Although SARS-CoV-2 infection is primarily associated with respiratory symptoms, neurological complications have been...

Prevalence of 406 rare diseases by ethnicity and recorded COVID-19 infection rates among 62.5 million people in England Abstract Rare diseases (RD) are individually uncommon but collectively affect millions of people. Yet national estimates of their prevalence, especially across ethnic...

Neurological, Neuromuscular, and Autonomic Manifestations of COVID-19: A Retrospective Study Abstract Background Neurovascular, neuromuscular, and autonomic complications of COVID-19 have rarely been characterized within a single cohort. Objective To compare the clinical, electrodiagnostic...

Pathogen and Testing Profiles in Post-Infectious Irritable Bowel Syndrome Across the COVID-19 Public Health Emergency: A Retrospective Case Series Abstract Background/Objectives: The COVID-19 public health emergency altered enteric infection surveillance, diagnostic testing, and antibiotic...

Comparative effectiveness of proactive exposure management and illness-based exclusion strategies for COVID-19 in healthcare personnel Amanda Brown Marusiak 1 , Hilary Babcock 2 , Emily Sickbert-Bennett 1 , Daniel Westreich 1 , Justin Lessler 1 , David J Weber Abstract Objective: To...

Genome‐Wide Association Studies of Hospitalized Influenza Identify Four Risk Loci and Reveal Shared and Unique Genetic Factors Compared With COVID‐19 ABSTRACT Background Influenza remains a significant global health burden, potentially leading to hospitalization and mortality. Although...

Reproducible smoker’s paradox in COVID-19 - comparative evidence from Swedish and Norwegian cohorts Abstract Literature on the impact of smoking on COVID-19 has been inconsistent, and the association remains incompletely understood. To assess the effect of smoking on COVID-19 outcomes using...

Distinct CD8+ T cell types associated with COVID-19 severity in unvaccinated HLA-A2+ patients Abstract Despite emerging studies about coronavirus disease 2019 (COVID-19)-associated adaptive immune responses, CD8+ T cell immunity in the context of HLA restriction, particularly in unvaccinated...

Autoantibodies neutralizing type I interferons in COVID-19 patients from southern Brazil Abstract Inborn errors of type I IFN (IFN-I) immunity and neutralizing autoantibodies (auto-Abs) against IFN-I (AAN-I-IFNs) impair antiviral immunity and underlie critical COVID-19. Their impact on...

Non-fluorescent benzothiadiazole probe with protein-triggered turn-on fluorescence for imaging SARS-CoV-2 spike protein in biological systems Highlights A non-fluorescent benzothiadiazole probe becomes strongly emissive after protein ligation. Acid-to-amide conversion yields an approximately...

Effectiveness of COVID-19 Vaccination and Prior Infections to Reduce Long COVID Risk During the Pre-Omicron and Omicron Periods Abstract Background We estimated vaccine effectiveness (VE) against COVID-19 and long COVID during pre-Omicron and Omicron periods, by number of doses and prior...

Viral Burden and Illness Severity During Acute SARS-CoV-2 Infection Predict Persistent Long COVID Symptoms Abstract Background Long COVID is a common complication of infection with severe acute respiratory syndrome coronavirus 2, but the prevalence and predictors of the condition remain...

Five-year Quantitative Chest CT and Hyperpolarized Xenon 129 Ventilation MRI Findings in Survivors of COVID-19 Pneumonia Abstract Background Whether pulmonary sequelae persist 5 years after COVID-19 pneumonia remains unknown. Purpose To evaluate 5-year pulmonary abnormalities in survivors of...

Localized SARS-CoV-2 Infection Triggers a Tissue-Wide Antiviral Response and Functional Impairment of Olfactory Sensory Neurons Abstract Olfactory dysfunction is a hallmark of COVID-19, yet the mechanisms by which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes...

COVID-19 infection raises respiratory type 2 inflammatory disease risk, whereas vaccination is protective Abstract Background Coronavirus disease 2019 (COVID-19) infection and vaccination have unclear impacts on type 2 inflammatory diseases. Although viral infections can drive immune...

https://www.bbc.co.uk/future/article/20260917-confusion-in-the-immune-system-how-allergies-can-develop-later-in-life 1400-word article. Excerpt: The Covid 'on switch' Some people are born with a genetic predisposition to allergy. But "it's not all genetics," says Ruchi Gupta, director of...

REmotely monitored, Mobile health-supported Multidomain Rehabilitation with High Intensity Interval Training for COVID-19 (REMM-HIIT-CoV): Trial Design and Rationale Abstract Importance Individuals hospitalized with COVID-19 are at increased risk for prolonged physical, cognitive, and...