dopamine

Hello I have been working on an ME Hypothesis for the last few years. It describes three types of noradrenergic neuron dysfunction, two of which are mediated by insulin. Of course, there could be more subtypes not suggested in this hypothesis. I have made a video explaining the hypothesis-...

ABSTRACT Objectives: The aim of this study was to investigate the role of serum niacin and dopamine (DA) levels and their clinical importance in fibromyalgia syndrome (FMS) patients. Patients and methods: Between April 2018 and October 2018, a total of 53 female patients (mean age: 38.3±5.5...

Interesting review of research on the impact of inflammation on the dopamine system as well as a theoretical model and computational method trying to connect it all. Could be a hypothesis as to why Abilify and dopaminergic agents have some partial efficacy in ME, even if it is temporary (so...

https://www.clinicaltrials.gov/ct2/show/NCT04622293 https://thejewishnews.com/2020/10/07/new-hope-for-chronic-fatigue-sufferers/

Mentioned in this thread Differentiating post-polio syndrome from myalgic encephalomyelitis and chronic fatigue syndrome, 2019, Jason et al Richard L. Bruno, HD, PhD, et al. American Journal of Medicine,1998, 105 (3A): 66-73...

Why is there motor deterioration in Parkinson’s disease during systemic infections-a hypothetical view. https://www.nature.com/articles/npjparkd201514 I can't read all of this, but I thought it sounded intriguing because some PWME report actually feeling better during an infection. Posting in...

OK brain trust! :hug: My own thread about how pwME ignore symptoms that may be something else has shamed me. Apologizing in advance for the long description of the symptom/history, but it's complex. Using boldface to try and make it easier to read! About a year ago working at Stanford, my...

The work was done in mice. The method used to modulate dopamine levels - optogenetics - was new to me, and fascinating. The researchers think their work has relevance to depression and PTSD. Should low dopamine levels prove to be relevant in ME, some of the results from the study may also...

For those interested in these things this is a useful review (and hypothesis) of possible mechanisms for 'central fatigue' in MS and other neurological disorders (full paper). Not directly relevant to ME/CFS although several ME/CFS studies are referenced. Possibly the most interesting (and...