immune system

Abstract The underlying pathologies driving post-acute infectious syndromes (e.g. myalgic encephalomyelitis / chronic fatigue syndrome, long COVID, etc) remain poorly understood. Given the extreme burden these illnesses impose on suffers, and the dramatic increase in cases following the COVID-19...

Rates of infection with other pathogens after a positive COVID-19 test versus a negative test in US veterans November, 2021, to December, 2023: a retrospective cohort study Miao Cai; Evan Xu; Yan Xie; Ziyad Al-Aly BACKGROUND SARS-CoV-2 infection leads to post-acute sequelae that can affect...

Proteomic analysis of post-COVID condition: Insights from plasma and pellet blood fractions Alejandro Seco-González, Paula Antelo-Riveiro, Susana B. Bravo, P.F. Garrido, M.J. Domínguez-Santalla, E. Rodríguez-Ruiz, Á. Piñeiro, R. Garcia-Fandino Background Persistent symptoms extending beyond...

mTOR inhibition improves immune function in the elderly Joan B. Mannick, Giuseppe Del Giudice, Maria Lattanzi, Nicholas M. Valiante, Jens Praestgaard, Baisong Huang, Michael A. Lonetto, Holden T. Maecker, John Kovarik, Simon Carson, David J. Glass, Lloyd B. Klickstein Abstract Inhibition of...

The choroid plexus synergizes with immune cells during neuroinflammation Huixin Xu; Peter Lotfy; Sivan Gelb; Aja Pragana; Christine Hehnly; Lillian I.J. Byer; Frederick B. Shipley; Miriam E. Zawadzki; Jin Cui; Liwen Deng; Milo Taylor; Mya Webb; Hart G.W. Lidov; Mark L. Andermann; Isaac M. Chiu...

Cellular and Molecular Effects of Microgravity on the Immune System: A Focus on Bioactive Lipids Fava, Marina; De Dominicis, Noemi; Forte, Giulia; Bari, Monica; Leuti, Alessandro; Maccarrone, Mauro Microgravity is one of the main stressors that astronauts are exposed to during space missions...

Gut permeability among Astronauts during Space missions Akinsuyi; Xhumari; Ojeda; Roesch The space environment poses substantial challenges to human physiology, including potential disruptions in gastrointestinal health. Gut permeability has only recently become widely acknowledged for its...

Rethinking coagulation: from enzymatic cascade and cell-based reactions to a convergent model involving innate immune activation Yong, Jun; Toh, Cheng-Hock Advancements in the conceptual thinking of hemostasis and thrombosis have been catalyzed by major developments within health research over...

Prevalence of autoimmune diseases in functional neurological disorder: influence of psychiatric comorbidities and biological sex Anna Joseph; Gaston Baslet; Mary A O’Neal; Ginger Polich; Irene Gonsalvez; Andrea N Christoforou; Barbara A Dworetzky; Primavera A Spagnolo BACKGROUND Functional...

Systems analysis of innate and adaptive immunity in Long COVID Peluso; Abdel-Mohsen; Henrich; Roan Since the onset of the COVID-19 pandemic, significant progress has been made in developing effective preventive and therapeutic strategies against severe acute SARS-CoV-2 infection. However, the...

Sex differences in symptomatology and immune profiles of Long COVID Julio Silva; Takehiro Takahashi; Jamie Wood; Peiwen Lu; Sasha Tabachnikova; Jeffrey Gehlhausen; Kerrie Greene; Bornali Bhattacharjee; Valter Silva Monteiro; Carolina Lucas; Rahul Dhodapkar; Laura Tabacof; Mario Pena-Hernandez...

Immune Status of Individuals with Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis Valido, Ezra; Boehl, Gabriela; Krebs, Jörg; Pannek, Jürgen; Stojic, Stevan; Atanasov, Atanas G.; Glisic, Marija; Stoyanov, Jivko Individuals with spinal cord injury (SCI) have higher infection...

From aging to long COVID: exploring the convergence of immunosenescence, inflammaging, and autoimmunity Müller, Ludmila; Di Benedetto, Svetlana The process of aging is accompanied by a dynamic restructuring of the immune response, a phenomenon known as immunosenescence. This mini-review...

The lung microbiome regulates brain autoimmunity Hosang, Leon; Canals, Roger Cugota; van der Flier, Felicia Joy; Hollensteiner, Jacqueline; Daniel, Rolf; Flügel, Alexander; Odoardi, Francesca Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated autoimmune...

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity Heinz; Baumann; Köberlin; Snijder; Gawish; Shui; Sharif; Aspalter; Müller; Kandasamy; Breitwieser; Pichlmair; Bruckner; Rebsamen; Blüml; Karonitsch; Fauster; Colinge; Bennett; Knapp; Superti-Furga Lipid metabolism and...

SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution Rafael J. Argüello; Alexis J. Combes; Remy Char; Julien-Paul Gigan; Ania I. Baaziz; Evens Bousiquot; Voahirana Camosseto; Bushra Samad; Jessica Tsui; Peter Yan; Sebastien Boissonneau...

Primary oxidative phosphorylation defects lead to perturbations in the human B cell repertoire Gordon-Lipkin, Eliza M.; Banerjee, Payal; Franco, Jose Luis Marin; Tarasenko, Tatiana; Kruk, Shannon; Thompson, Elizabeth; Gildea, Derek E.; Zhang, Suiyuan; Wolfsberg, Tyra G.; NISC Comparative...

Suppressed immune and metabolic responses to intestinal damage-associated microbial translocation in myalgic encephalomyelitis/chronic fatigue syndrome Uhde; Indart; Green; Yolken; Cook; Shukla; Vernon; Alaedini The etiology and mechanism of myalgic encephalomyelitis/chronic fatigue syndrome...

Human Immune Cell Epigenomic Signatures in Response to Infectious Diseases and Chemical Exposures Wenliang Wang; Manoj Hariharan; Anna Bartlett; Cesar Barragan; Rosa Castanon; Vince Rothenberg; Haili Song; Joseph Nery; Andrew Aldridge; Jordan Altshul; Mia Kenworthy; Wubin Ding; Hanqing Liu; Wei...

Brain borders at the central stage of neuroimmunology Rustenhoven, Justin; Kipnis, Jonathan The concept of immune privilege suggests that the central nervous system is isolated from the immune system. However, recent studies have highlighted the borders of the central nervous system as central...