Gastrointestinal Barrier Disruption in Post-COVID Syndrome Fatigue Patients
Johanna Rohrhofer; Viktoria Wolflehner; Johannes Schweighardt; Larissa Koidl; Michael Stingl; Sonja Zehetmayer; Joana Séneca; Petra Pjevac; Eva Untersmayr
BACKGROUND
Post-COVID Syndrome (PCS) is the term for a condition...
Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity
Feilong Wang ∙ Song Zhang ∙ Ryounghoon Jeon ∙ Ivan Vuckovic ∙ Xintong Jiang∙ Amir Lerman∙ Clifford D. Folmes ∙ Petras D. Dzeja ∙ Joerg Herrmann
Highlights...
Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA Sequencing
Marta Līva Spriņģe; Kristīne Vaivode; Rihards Saksis; Nineļa Miriama Vainšeļbauma; Laura Ansone; Monta Brīvība; Helvijs Niedra; Vita Rovite
Long-COVID affects at least 10% of COVID-19...
Abstract
For decades, antigen presentation on major histocompatibility complex class I for T cell-mediated immunity has been considered the primary function of proteasome-derived peptides1,2.
However, whether the products of proteasomal degradation play additional parts in mounting immune...
Dysrupted microbial tryptophan metabolism associates with SARS-CoV-2 acute inflammatory responses and long COVID
Lu Yao; Hannah Devotta; Junhui Li; Nonhlanhla Lunjani; Corinna Sadlier; Aonghus Lavelle; Werner C. Albrich; Jens Walter; Paul W. O’Toole; Liam O’Mahony
Protection against severe...
Peptides from non-immune proteins target infections through antimicrobial and immunomodulatory properties
Marcelo D.T. Torres; Angela Cesaro; Cesar de la Fuente-Nunez
Encrypted peptides (EPs) have been recently described as a new class of antimicrobial molecules. They have been found in...
Immune exhaustion in ME/CFS and long COVID
Natalie Eaton-Fitch; Penny Rudd; Teagan Er; Livia Hool; Lara Herrero; Sonya Marshall-Gradisnik
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are debilitating multisystemic conditions sharing similarities in immune...
Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19
Sascha N. Goonewardena; Qinzhong Chen; Ashley M. Tate; Olga G. Grushko; Dilna Damodaran; Pennelope K. Blakely; Salim S. Hayek; David J. Pinsky; Robert S. Rosenson
BACKGROUND
SARS-CoV-2 infections...
Numerous people are being diagnosed as having CFS and fibro after apparent remission of sarcoidosis. Numerous questions arise
1) What does the diagnoser know about CFS or fibro?
2) What does the diagnoser know about work on post sarcoid fatigue vs sarcoid e.g. persistent shift to TH1 in post...
Cellular and Molecular Effects of Microgravity on the Immune System: A Focus on Bioactive Lipids
Fava, Marina; De Dominicis, Noemi; Forte, Giulia; Bari, Monica; Leuti, Alessandro; Maccarrone, Mauro
Microgravity is one of the main stressors that astronauts are exposed to during space missions...
SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19
Guarnieri; Haltom; Albrecht; Lie; Olali; Widjaja; Ranshing; Angelin; Murdock; Wallace
To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an exhaustive survey of the cellular metabolic...
Rethinking coagulation: from enzymatic cascade and cell-based reactions to a convergent model involving innate immune activation
Yong, Jun; Toh, Cheng-Hock
Advancements in the conceptual thinking of hemostasis and thrombosis have been catalyzed by major developments within health research over...
Systems analysis of innate and adaptive immunity in Long COVID
Peluso; Abdel-Mohsen; Henrich; Roan
Since the onset of the COVID-19 pandemic, significant progress has been made in developing effective preventive and therapeutic strategies against severe acute SARS-CoV-2 infection. However, the...
Defining trained immunity and its role in health and disease
Netea, Mihai G.; Domínguez-Andrés, Jorge; Barreiro, Luis B.; Chavakis, Triantafyllos; Divangahi, Maziar; Fuchs, Elaine; Joosten, Leo A. B.; van der Meer, Jos W. M.; Mhlanga, Musa M.; Mulder, Willem J. M.; Riksen, Niels P.; Schlitzer...
Functional Reciprocity of Amyloids and Antimicrobial Peptides: Rethinking the Role of Supramolecular Assembly in Host Defense, Immune Activation, and Inflammation
Lee EY; Srinivasan Y; de Anda J; Nicastro LK; Tükel Ç; Wong GCL;
Pathological self-assembly is a concept that is classically...
Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants
Nature, open access: https://www.nature.com/articles/s41564-023-01588-4
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) human adaptation resulted in distinct lineages with enhanced...
Sex-dependent differences in type I IFN-induced natural killer cell activation
Pujantell, Maria; Skenteris, Nikolaos-Taxiarchis; Claussen, Janna Marieke; Grünhagel, Benjamin; Thiele, Rebecca-Jo; Altfeld, Marcus
Natural killer (NK) cells are important antiviral effector cells and also involved...
Proteomic Evolution from Acute to Post-COVID-19 Conditions
Yassene Mohammed; Karen Tran; Chris Carlsten; Christopher Ryerson; Alyson Wong; Terry Lee; Matthew P. Cheng; Donald C. Vinh; Todd C. Lee; Brent W. Winston; David Sweet; John H. Boyd; Keith R. Walley; Greg Haljan; Allison McGeer; Francois...
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