interferon

  1. SNT Gatchaman

    Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation, 2025, White et al.

    Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation White, Zachary; Cabrera, Ivan; Mei, Linghan; Clevenger, Margarette; Ochoa-Raya, Andrea; Kapustka, Isabel; Dominguez, Joseph R.; Zhou, Jinyan; Koster, Kevin P.; Anwar, Shehata; Wang, Qianxun; Ng, Charles; Sagoshi...
  2. jnmaciuch

    Timeline of interferon, autoantibodies, and autoimmune disease development

    Posting several links exploring temporal dynamics between interferon, autoantibodies, and autoimmune diseases (primarily lupus). (Review) Emerging concepts of type I interferons in SLE pathogenesis and therapy Note: SLE = systemic lupus erythematosus Links to references are active in the...
  3. SNT Gatchaman

    Preprint SARS-CoV-2-induced dysregulation in ADAR editing patterns persists post viral clearance in individuals with mild COVID-19, 2025, Nair & Piontkivska

    SARS-CoV-2-induced dysregulation in ADAR editing patterns persists post viral clearance in individuals with mild COVID-19 Aiswarya Mukundan Nair; Helen Piontkivska Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections remain a public health concern worldwide. Viral antigen...
  4. forestglip

    [Transcriptome] in PBMCs of [LC] at a median follow-up of 28 months [...] reveals upregulation of JAK/STAT [...], 2025, Fineschi et al

    Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response Serena Fineschi, Joakim Klar, Juan Ramon Lopez Egido, Jens Schuster, Jonas Bergquist...
    • forestglip
    • Thread
    • annexin atp haemoglobin histone il-9 interferon jak-stat lactate long covid mitochochria mitochondrial dysfunction neutrophils oxidative phosphorylation ubiquitination
    • Replies: 19
    • Forum: Long Covid research
  5. jnmaciuch

    Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits its activation to suppress viral replication and pathogenesis, Chakravarty+

    Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits its activation to suppress viral replication and pathogenesis (2023) Sukanya Chakravarty, Gayatri Subramanian, Sonam Popli, Manoj Veleeparambil, Shumin Fan, Ritu Chakravarti, Saurabh Chattopadhyay Department of Medical...
  6. Hutan

    Neopterin

    Petrichor noted here A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff that some papers have reported elevated levels of neopterin in ME/CFS. That's interesting because macrophages produce neopterin when stimulated with...
  7. Nightsong

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    Abstract: Evidence bearing on possible mechanisms for the clinical syndrome of ME/CFS is reviewed. The evidence is used to argue for a hypothesis that centres on a form of persistent, inappropriate, ‘neuroimmune hypervigilance’ mediated primarily by T lymphocyte-macrophage interaction but...
    • Nightsong
    • Thread
    • cd64 fcγri igg iggr interferon interferon gamma jackie cliff jo cambridge jonathan edwards t cells
    • Replies: 594
    • Forum: ME/CFS research
  8. Jonathan Edwards

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Link to the thread on the preprint - 27 May 2025: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff ****** I am hoping that the paper I have been writing with Jo Cambridge and Jackie Cliff will appear on Qeios tomorrow. If...
  9. SNT Gatchaman

    Longitudinal lipoprotein and inflammatory mediators analysis uncover persisting inflammation and hyperlipidemia…, 2025, Bae+

    Longitudinal lipoprotein and inflammatory mediators analysis uncover persisting inflammation and hyperlipidemia following SARS-CoV-2 infection in long COVID-19 Bae, Gyuntae; Yang, Zhiqi; Bucci, Daniele; Wegner, Claire; Schäfer, Hartmut; Singh, Yogesh; Lonati, Caterina; Trautwein, Christoph...
  10. SNT Gatchaman

    Immune disturbances in individuals with post-COVID syndrome are not characterized by enhanced SARS-CoV-2-specific immunity, 2025, Ober+

    Immune disturbances in individuals with post-COVID syndrome are not characterized by enhanced SARS-CoV-2-specific immunity Ober, Veronica; Völk, Felix; Sbierski-Kind, Julia; Gruener, Eva; Stirner, Renate; Reiling, Gabriele; Feldmann, Svenja; Ibarra, Gerardo; Seybold, Ulrich; Stubbe, Hans...
  11. SNT Gatchaman

    Hyper-reactivity of CD8+ T cells and high expression of IL-3 correlates with occurrence and severity of Long-COVID, 2025, Renner et al.

    Hyper-reactivity of CD8+ T cells and high expression of IL-3 correlates with occurrence and severity of Long-COVID Renner; Stauffenberg; Paulus; Neumayer; Winter-Köhler; Buchtler; Schmalenberger; Blaas; Mohr; Pfeifer; Malfertheiner; Loew; Sester; Bals; Peterhoff; Schmidt; Mack Following...
  12. forestglip

    [Clinical characteristics and cytokine gene expression in patients with post-COVID-19 syndrome], 2025, Valencia-Gutiérrez et al

    [Clinical characteristics and cytokine gene expression in patients with post-COVID-19 syndrome] María Magdalena Valencia-Gutiérrez , Modesto Gómez-López, Nadia Mabel Pérez-Vielma, Paulina Lázaro-Aguilar, Víctor Ricardo Aguilera-Sosa Background Post-COVID-19 syndrome occurs 3 months after...
  13. Mij

    Itaconate modulates immune responses via inhibition of peroxiredoxin 5, 2025, Tomas Paulenda et al

    Abstract The immunoregulatory metabolite itaconate accumulates in innate immune cells upon Toll-like receptor stimulation. In response to macrophage activation by lipopolysaccharide, itaconate inhibits inflammasome activation and boosts type I interferon signalling; however, the molecular...
  14. Mij

    Itaconate boosts type I IFN response by disrupting cytoprotection, 2025, Theresa Ramalho

    A new study reveals a surprising mechanism by which itaconate inhibits the active site of a peroxiredoxin enzyme to amplify redox signalling and the type I interferon response in macrophages. Paywalled
  15. SNT Gatchaman

    Effects of a mild inflammatory challenge on cytokines and sickness behavior: A randomized controlled trial using the influenza vaccine, 2025, Jolink+

    Effects of a mild inflammatory challenge on cytokines and sickness behavior: A randomized controlled trial using the influenza vaccine Jolink; Feldman; Antenucci; Cardenas; West; Nakamura; Muscatell The influenza vaccine has reliably been associated with mild, within-person increases in...
  16. SNT Gatchaman

    Preprint Systemic Multi-Omics … Reveals Interferon Response Heterogeneity & Links Lipid Metabolism to Immune Alterations in Severe COVID, 2025, Lira-Junior+

    Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19 Ronaldo Lira-Junior; Anoop Ambikan; Axel Cederholm; Ssefanit Rezene; Flora Mikaeloff; Sara Svensson Akusjarvi; Ahmet Yalcinkaya; Xi Chen; Maike Sperk...
    • SNT Gatchaman
    • Thread
    • amino acids immunometabolic innate immune response interferon interferon-stimulated genes lipids metabolomics mitochondria monocytes neopterin neutrophils plasmalogen proteomics sphingolipids tryptophan
    • Replies: 1
    • Forum: Long Covid research
  17. SNT Gatchaman

    Preprint Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA Sequencing, 2025, Spriņģe et al.

    Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA Sequencing Marta Līva Spriņģe; Kristīne Vaivode; Rihards Saksis; Nineļa Miriama Vainšeļbauma; Laura Ansone; Monta Brīvība; Helvijs Niedra; Vita Rovite Long-COVID affects at least 10% of COVID-19...
  18. SNT Gatchaman

    The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and [vaccination], 2025, Maatz+

    The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination Maatz, Henrike; Lindberg, Eric L.; Adami, Eleonora; López-Anguita, Natalia; Perdomo-Sabogal, Alvaro; Cocera Ortega, Lucía; Patone, Giannino; Reichart...
  19. Mij

    Immunological and clinical markers of PASC: Insights from mild and severe cases six months post-infection, 2025, William Mouton et al

    Abstract Post-acute sequelae of COVID-19 (PASC) is a complex and multifaceted clinical challenge requiring to emphasize its underlying pathophysiological mechanisms. This study assessed hundreds of virological, serological, immunological, and tissue damage biomarkers in two patient cohorts who...
    • Mij
    • Thread
    • cmv cortisol ebv interferon t cells viral persistence
    • Replies: 9
    • Forum: Long Covid research
  20. SNT Gatchaman

    Review Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Syed, Karius, Wang, Hwang

    Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Abu Mohammad Syed; Alexander K. Karius; Jin Ma; Ping-yuan Wang; Paul M. Hwang ME/CFS is a debilitating multisystem disorder of unclear etiology that affects many individuals worldwide. One of its hallmark symptoms...
    • SNT Gatchaman
    • Thread
    • actin atp eif2a endoplasmic reticulum er stress interferon jak-stat mitochochria mitochondrial dysfunction nf-κb wasf3
    • Replies: 15
    • Forum: ME/CFS research
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