interferon

Robust antibody and T cell responses tracked longitudinally in patients with long COVID After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a minority of patients experience persistent or emerging symptoms, termed ‘long coronavirus disease (COVID) or post-acute...

Whole genome sequence meta-analyses reveal common and rare genetic associations with critical COVID-19 In susceptible patients, COVID-19 causes life-threatening disease driven by immune-mediated inflammatory lung injury. We have previously shown that multiple common host genetic variants are...

Digitally Assessed Long COVID Symptomatology Is Associated With Lymphocyte Mitochondrial Dysfunction and Altered Immune Potential BACKGROUND Postacute sequelae of SARS-CoV-2 infection, also known as long COVID (LC), is a complex and heterogenous condition affecting millions worldwide with a...

Evolutionary rewiring of host metabolism and interferon signalling by SARS-CoV-2 variants SARS-CoV-2 variants differ in transmissibility and immune evasion, but their effects on host-cell metabolism and signalling remain less defined. Using integrated transcriptomic, phosphoproteomic, and...

Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation The cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS)-cyclic GMP-AMP (cGAMP)-stimulator of interferon genes (STING) pathway mediates antiviral innate...

Cell Polarization and Epigenetic Status Shape the Heterogeneous Response to Type III Interferons in Intestinal Epithelial Cells Authors: Sudeep Bhushal, Markus Wolfsmüller, Tharini A. Selvakumar, Lucas Kemper, Dagmar Wirth, Mathias W. Hornef, Hansjrg Hauser, Mario Kster Abstract [paragraph...

Blood diagnostic biomarkers for neurologic manifestations of long COVID BACKGROUND SARS-CoV-2 responsible for COVID-19 caused a global pandemic, with billions of infections, millions of deaths and ongoing manifestations post COVID-19. “Long Covid”, a Post-Acute Sequelae of COVID-19 (PASC), is...

Link Highlights • Viruses induce depressive behavior and ISG15 expression at the blood-brain barrier • IFNAR1 expression on neural cells is not involved in IFN-β-induced sickness behavior • IFNAR1 expression on brain endothelial and epithelial cells drives behavioral changes • Brain...

I have mentioned elsewhere that I describe PEM as being like having the flu, or another significant infection. I think there are studies that show that cognition is negatively affected during an acute infection, and I don't think it is just the distraction of pain. And I think there are...

Autoantibodies against type I interferons are a prominent feature in SARS-CoV-2 fatal disease and hospitalization Rebeca Linhares Abreu Netto, Catherine Chen, Victor Irungu Mwangi, Carlos Eduardo Padron de Morais, Mariana Simão Xavier, Luiz Gustavo Gardinassi, Emily Marie Eriksson, Nicholas...

Metabolism and Innate Immunity Meet at the Mitochondria Bahat, A., MacVicar, T., & Langer, T Abstract Mitochondria are master regulators of metabolism and have emerged as key signalling organelles of the innate immune system. Each mitochondrion harbours potent agonists of inflammation...

The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders Missiroli S, Genovese I, Perrone M, Vezzani B, Vitto VAM, Giorgi C Abstract The main features that are commonly attributed to mitochondria consist of the regulation of cell proliferation, ATP generation, cell...

A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity The alpha-variant wave of the COVID-19 pandemic provided a unique opportunity to study, at single-cell resolution, how near-universal exposure to the same pathogen can lead to either effective or...

Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylation Interferon-stimulated gene 15 (ISG15) regulates diverse cellular responses including antiviral immunity through its conjugation to proteins, a process known as ISGylation. Several pathogens, including...

Interferons in health and disease Daniel Boehmer; Ivan Zanoni Interferons (IFNs) are signaling proteins that play fundamental roles during health and disease. Although types I, II, and III IFNs are structurally and functionally different, all IFNs signal via an intricate network of Janus...

Interferon-Linked Lipid and Bile Acid Imbalance Uncovered in Ankylosing Spondylitis in a Sibling-Controlled Multi-Omics Study Ankylosing spondylitis (AS) displays wide inter-patient variability that is not accounted for by HLA-B27 alone, suggesting that additional immune and metabolic...

Unphosphorylated ISGF3 drives constitutive expression of interferon-stimulated genes to protect against viral infections Wenshi Wang, Yuebang Yin, Lei Xu, Junhong Su, Fen Huang, Yijin Wang, Patrick P. C. Boor, Kan Chen, Wenhui Wang, Wanlu Cao, Xinying Zhou, Pengyu Liu, Luc J. W. van der Laan...

Single-cell RNA-sequencing highlights a curtailed NK cell function in convalescent COVID-19 pregnant women Salker, Madhuri S. ; Abd Aziz, Nor Haslinda ; Prodan, Natalia Carman ; Yang, Zhiqi ; Lankapalli, Aditya Kumar ; Lazar, Katrin ; Shafiee, Mohamad Nasir ; Kocak, Ersoy ; Ganesan, Harivignesh...

In Silico Analysis of Post-COVID-19 Condition PCC Associated SNP rs9367106 Predicts the Molecular Basis of Abnormalities in the Lungs and Brain Functions Maiti, Amit K. Long-or post-COVID-19 syndrome, which is also designated by WHO as Post COVID-19 Condition (PCC), is characterized by the...

Glucose uptake in activated CD4+ T cells is essential for increased metabolic needs, synthesis of biomolecules and proliferation. Although, facilitated glucose transport is the predominant route for glucose entry at the time of activation, here we demonstrate role for the sodium-dependent...