lactate

Pilot Study of Peripheral Muscle Function in Primary Biliary Cirrhosis: Potential Implications for Fatigue Pathogenesis BACKGROUND & AIMS Primary biliary cirrhosis (PBC) is characterized in 95% of patients by autoantibody responses directed against the mitochondrial antigen pyruvate...

Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome OBJECTIVES To examine muscle acid handling following exercise in chronic fatigue syndrome (CFS⁄ME) and the relationship with autonomic dysfunction. DESIGN...

Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis BACKGROUND & AIMS Upon exercise, primary biliary cirrhosis (PBC) is associated with significant acidosis in peripheral muscle with recovery rate from acidosis strongly...

Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: a case–control study BACKGROUND Chronic fatigue syndrome (CFS) patients frequently describe difficulties with repeat exercise. Here, we explore muscle bioenergetic function in response to three bouts of...

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender Excessive exercise impairs cognitive function, but the underlying mechanism remains unclear. Here, we show that excessive vigorous exercise-induced lactate accumulation stimulates muscles to...

Glymphatic clearance controls state-dependent changes in brain lactate concentration Brain lactate concentration is higher during wakefulness than in sleep. However, it is unknown why arousal is linked to an increase in brain lactate and why lactate declines within minutes of sleep. Here, we...

Pursuing Reduction in Fatigue After COVID-19 via Exercise and Rehabilitation PREFACER: a protocol for a randomised feasibility trial INTRODUCTION Over 777 million COVID-19 infections have occurred globally, with data suggesting that 10%–20% of those infected develop Long COVID. Fatigue is one...

Neurometabolite alterations in Gulf War Illness: a whole-brain magnetic resonance spectroscopy study Chloe Jones, Olivia Haskin, Jarred Younger [Line breaks added] Abstract Gulf War Illness (GWI) affects approximately 30% of veterans who served in the 1991 Persian Gulf War and is...

Erythrocytes as a Source of Exerkines Exercise activates many metabolic and signaling pathways in skeletal muscle and other tissues and cells, causing numerous systemic beneficial metabolic effects. Traditionally recognized for their principal role in oxygen (O2) transport, erythrocytes have...

Dysregulated oxidative stress and lactate levels in treatment-resistant schizophrenia Fang; Zhang; Xu; Wang; He; Liao; Yuan; Tang Schizophrenia is a severe and clinically heterogeneous mental disorder, with approximately 30 % of patients developing treatment resistance to standard...

Identifying the Neurobiological Substrates of Gulf War Illness by Chloe Jones Jarred Younger, Committee Chair; Adam Goodman; Maxine Krengel; Virendra Mishra; Robert Sorge [Line breaks added] Abstract Gulf War Illness (GWI) affects approximately 30% of veterans who served in the 1991 Persian...

Mitochondrial activity tunes nociceptor resilience to excitotoxicity Lin Yuan; Navdeep S Chandel; David Julius The capsaicin receptor, TRPV1, mediates the detection of noxious chemical and thermal stimuli by nociceptors, primary sensory neurons of the pain pathway. Overactivation of TRPV1 leads...

The Roles of Lactate and Lactylation in Diseases Related to Mitochondrial Dysfunction Ma, Fei; Yu, Wei Glycolysis and oxidative phosphorylation are the main pathways of cellular energy production. Glucose is metabolized via glycolysis to generate pyruvate, which, under anaerobic conditions, is...

Abstract Post-translational modifications (PTMs) regulate protein structure, function, and interactions, playing pivotal roles in cellular processes and disease progression. Lactate, a byproduct of the Warburg effect, accumulates excessively during viral infections and functions as a signaling...

Abstract Lactate is a critical regulator of cellular processes and immune signaling, and we hypothesize that exercise-induced elevations in lactate help activate immune cells in response to vigorous exercise. Despite its importance, the impact of lactate on T-cell mitochondrial respiration...

Link to the published paper here ***************************************** This is a preliminary presentation: https://academic.oup.com/ijnp/article/28/Supplement_1/i60/8009437 https://academic.oup.com/ijnp/article-pdf/28/Supplement_1/i60/61854477/pyae059.104.pdf Journal Article MECHANISMS...

Wuhan strain of SARS-CoV-2 triggers activation of immune evasion machinery similar to the one operated by cancer cells Abooali, Maryam ; Yasinska, Inna M. ; Thapa, Gauri ; Lei, Xi ; da Costa, Kelly A. S. ; Schlichtner, Stephanie ; Berger, Steffen M. ; Fasler-Kan, Elizaveta ; Temperton, Nigel J...

Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response Serena Fineschi, Joakim Klar, Juan Ramon Lopez Egido, Jens Schuster, Jonas Bergquist...

Copied post - about a tweet by Putrino suggesting that mitochondrial dysfunction causes lactic acid, which causes PEM It would be nice with an explanation for why lactic acid causes PEM..

https://www.tandfonline.com/doi/abs/10.1080/21641846.2025.2483112 Research Article Caffeine against persistent fatigue in long-COVID: a randomized clinical trial Liziane Rosa Cardoso Maria Cristine Campos Tatyana Nery Ana Cristina de Bem Alves Ana Elisa Speck Naiara Souza dos Santos Izabel...