lactate

Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety disorder: an in vivo 3.0 T 1H MRS imaging study Sanjay J. Mathew; Xiangling Mao; Kathryn A. Keegan; Susan M. Levine; Eric L. P. Smith; Linda A. Heier; Viktor Otcheretko; Jeremy D...

Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity Vermeulen, Ruud CW; Kurk, Ruud M; Visser, Frans C; Sluiter, Wim; Scholte, Hans R Background The aim of this study was to investigate...

Introduction Monitoring muscle metabolic activity via blood lactate is a useful tool for understanding the physiological response to a given exercise intensity. Recent indications suggest that skeletal muscle oxygen saturation (SmO2), an index of the balance between local O2 supply and demand...

Impaired gut microbiota-mediated short-chain fatty acid production precedes morbidity and mortality in people with HIV Irini Sereti; Myrthe L. Verburgh; Jacob Gifford; Alice Lo; Anders Boyd; Eveline Verheij; Aswin Verhoeven; Ferdinand W.N.M. Wit; Maarten F. Schim van der Loeff; Martin Giera...

Abstract It is well known that glucose serves as the main energy substrate for the brain, and emerging evidence emphasizes its involvement in both physiological processes and disease (traumatic brain injury, memory, epilepsy, etc.). Furthermore, the usefulness of mathematical modeling in...

Regional quantification of cardiac metabolism with hyperpolarized 1-13C-pyruvate MRI evaluated in an oral glucose challenge Peder E. Z. Larson; Shuyu Tang; Xiaoxi Liu; Avantika Sinha; Nicholas Dwork; Sanjay Sivalokanathan; Jing Liu; Robert Bok; Karen G Ordovas; James Slater; Jeremy Gordon; Maria...

Peripheral measurements of venous oxygen saturation and lactate as a less invasive alternative for hemodynamic monitoring Chemtob, Raphaelle Avigael; Møller-Sørensen, Hasse Background Peripheral measurement of venous oxygen saturation and lactate is a less invasive alternative to monitor tissue...

Lactate is a glycolysis product that is produced from pyruvate by LDH (lactate dehydrogenase) and plays an important role in physiological and pathological processes. However, whether lactate regulates autophagy is still unknown. We recently reported that LDHA is phosphorylated at serine 196 by...

Decreased physical performance despite objective and subjective maximal exhaustion in post-COVID-19 individuals with fatigue Vollrath, Shirin; Matits, Lynn; Schellenberg, Jana; Kirsten, Johannes; Steinacker, Jürgen M.; Bizjak, Daniel A. Introduction Fatigue is a common symptom in post-COVID-19...

Metabolic regulation of gene expression by histone lactylation Zhang, Di; Tang, Zhanyun; Huang, He; Zhou, Guolin; Cui, Chang; Weng, Yejing; Liu, Wenchao; Kim, Sunjoo; Lee, Sangkyu; Perez-Neut, Mathew; Ding, Jun; Czyz, Daniel; Hu, Rong; Ye, Zhen; He, Maomao; Zheng, Y. George; Shuman, Howard A...

Lactic acid in macrophage polarization: The significant role in inflammation and cancer Hai-cun Zhou; Xin-yan Yan ; Wen-wen Yu; Xiao-qin Liang; Xiao-yan Du; Zhi-chang Liu; Jian-ping Long; Guang-hui Zhao; Hong-bin Liu Metabolite lactic acid has always been regarded as a metabolic by-product...

Neurovascular coupling is the concept that in the CNS, organ function is tightly associated with blood flow, moreso than in other organs. Theoretical background and latest thinking — From the introduction in The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in...

Abstract Lactate shuttled from the blood circulation, astrocytes, oligodendrocytes or even activated microglia (resident macrophages) to neurons has been hypothesized to represent a major source of pyruvate compared to what is normally produced endogenously by neuronal glucose metabolism...

The mechanism of Long Covid (Post-Acute Sequelae of COVID-19; PASC) is currently unknown, with no validated diagnostics or therapeutics. SARS-CoV-2 can cause disseminated infections that result in multi-system tissue damage, dysregulated inflammation, and cellular metabolic disruptions. The...

Measuring extracellular human brain pH and amino acid metabolism with hyperpolarized [1-13C]pyruvate Alixander S Khan; Mary A McLean; Joshua D Kaggie; Ines Horvat-Menih; Tomasz Matys; Rolf F Schulte; Matthew Locke; Ashley Grimmer; Pascal Wodtke; Elizabeth Latimer; Amy Frary; Martin J Graves...

Nuclear Magnetic Resonance Spectroscopy Metabolomics in Idiopathic Intracranial Hypertension to Identify Markers of Disease and Headache Grech O, Seneviratne SY, Alimajstorovic Z, Yiangou A, Mitchell JL, Smith TB, Mollan SP, Lavery GG, Ludwig C, Sinclair AJ Background and objective: We...

Abstract Previous studies have shown that monocytes can be ‘trained’ or tolerized by certain stimuli to respond stronger or weaker to a secondary stimulation. Rewiring of glucose metabolism was found to be important in inducing this phenotype. As we previously found that Borrelia burgdorferi...

Abstract Purpose: Previous studies in chronic fatigue syndrome (CFS) have reported reductions in maximal oxygen uptake (VO(2max)), yet often the testing procedures have not followed accepted guidelines, and gender data have been pooled. The present study was undertaken to reevaluate exercise...

Lactate: the ugly duckling of energy metabolism Rabinowitz JD, Enerbäck S Lactate, perhaps the best-known metabolic waste product, was first isolated from sour milk, in which it is produced by lactobacilli. Whereas microbes also generate other fermentation products, such as ethanol or acetone...

To the Editor: After acute infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many individuals experience a range of symptoms including dyspnea, exercise intolerance, and chest pain commonly referred to as “post–COVID-19 syndrome” or as post-acute sequelae of...