lipids

Explaining Fatigue and Post-Exertional Malaise in Long COVID and ME/CFS Charlton, Braeden Trey Abstract The SARS-CoV-2 viral outbreak in 2020 resulted in a record number of global hospitalizations and deaths. Although most people recover from an initial COVID infection within 3 months, around...

Multi-omic analysis of post-acute sequelae of COVID-19 (PASC) Abstract Millions of patients surviving COVID-19 infection develop post-acute sequelae of COVID-19 (PASC), a debilitating condition that severely disrupts quality of life. Limited data exists on PASC patient peripheral blood...

Long COVID is associated with lipoxygenase-catalyzed metabolism of essential polyunsaturated fatty acids Summary Long COVID (LC) represents a failure of healthy resolution mechanisms for inflammation after SARS-CoV-2 infection. Dietary essential polyunsaturated fatty acids (PUFAs) and their...

Lysophospholipid Mediators in Health and Disease Kuniyuki Kano; Junken Aoki; Timothy Hla Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are produced by the metabolism and perturbation of biological membranes. Both molecules are established...

The lipidomic architecture of the mouse brain Lipids are fundamental components of the brain, crucial for synaptic transmission and signal propagation. Altered brain lipid composition is associated with common and rare neuropathologies, yet the spatial organization of the mammalian brain...

Immediate Plasma Lipid Perturbations Following Cardiopulmonary Exercise Testing In Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) Christopoulos, Elena M.; Huang, Katherine; Howden, Erin J.; Talbot, Jack S.; Armstrong, Christopher W.; Moneghetti, Kegan J. PURPOSE Previous...

Lysophospholipid–TRPV1 interactions in chemotherapy-induced neuropathy Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting side effect of first-line chemotherapeutics such as paclitaxel, for which effective treatments are currently unavailable. We found that plasma...

LDLR-OPN Interaction Drives COVID-19 Myocarditis Through Monocyte Recruitment COVID-19–associated myocarditis is marked by macrophage-rich inflammation and adverse cardiac outcomes, yet its mechanisms remain unclear. We developed a reproducible BSL-2 mouse model by combining cardiac-specific...

Lipid membrane remodeling by myristic acid treatment reverses Parkinson’s disease α-synuclein phenotypes in patient neurons Despite the lipid-rich nature of the brain, defining the role of lipid metabolism in neurodegenerative disease and targeting lipid metabolic pathways for disease...

Association of ADIPOQ rs1501299 with long-COVID syndrome: a single-center cross-sectional study Background Long-COVID syndrome is a public health issue, affecting millions of individuals worldwide. However, the pathophysiological mechanisms underlying the syndrome’s sequelae are still under...

Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID Long COVID has emerged as a significant public health challenge with no effective treatments currently available, yet the pathophysiological mechanisms underlying its persistent...

Assessment of physical status and analysis of lipidomic and metabolomic alterations in patients with Post-COVID-19 condition The development and persistence of symptoms following SARS-CoV-2 infection, known as Post-COVID-19 Condition (PCC) or “long COVID,” represents a global health challenge...

Post-Translational Modification and Subcellular Compartmentalization: Emerging Concepts on the Regulation and Physiopathological Relevance of RhoGTPases Navarro-Lérida, Inmaculada; Sánchez-Álvarez, Miguel; del Pozo, Miguel Ángel Cells and tissues are continuously exposed to both chemical and...

"We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply." Daniel Missailidis...

Now published, see post #3. Post-translational modifications within fibrinaloid microclot complexes distinguish Pre-COVID-19 Postural Orthostatic Tachycardia Syndrome (POTS), Long COVID, and Long COVID-POTS and reveal disease-specific molecular pathways Background: Pre-COVID-19 Postural...

The Metabolic Aftershock: COVID-19 and Metabolic Disease Risk Among U.S. Active-Duty Military Personnel BACKGROUND The post-acute sequelae of SARS-CoV-2 infection represent a growing public health concern. While associations between COVID-19 and metabolic disorders have been reported, less is...

AMPA receptors in the synapse: Very little space and even less time Jelena Baranovic Glutamate is by far the most abundant neurotransmitter used by excitatory synapses in the vertebrate central nervous system. Once released into the synaptic cleft, it depolarises the postsynaptic membrane and...

Muscle Abnormalities in Nonhospitalised Patients With Post–COVID-19 Condition BACKGROUND Post-COVID condition (PCC) affects ~10% of SARS-CoV-2–infected individuals and manifests as persistent symptoms such as fatigue, exercise intolerance and muscle weakness. This study aimed to assess the...

Full title: Advancing Digital Precision Medicine for Chronic Fatigue Syndrome through Longitudinal Large-Scale Multi-Modal Biological Omics Modeling with Machine Learning and Artificial Intelligence We studied a generalized question: chronic diseases like ME/CFS and long COVID exhibit high...

https://www.news-medical.net/news/20250820/Women-with-Alzheimers-show-reduced-levels-of-healthy-unsaturated-fats.aspx