longitudinal study

Randomized controlled trial of pirfenidone XR for patients with COVID-19 and exploration of effects on long-COVID incidence Abstract Objective Evaluate safety and efficacy of extended-release pirfenidone (pirfenidone-XR), an anti-inflammatory and anti-fibrotic agent, as an early treatment for...

Long-term episodic memory alterations and the role of perceived stress in post-COVID-19 condition Abstract Post-COVID-19 condition (PCC) is frequently associated with cognitive impairments, but the integrity of long-term episodic memory remains poorly understood. This study examined...

Four-Year Longitudinal Phenotyping of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC): A Single-Centre Cohort Study Sárközi, Anna Teréz; Tornyi, Ilona; Horváth, Ildikó Abstract Background: Although an increasing number of studies have reported 2- and 3-year outcomes of post-acute sequelae...

Symptom-based clustering of post-COVID patients and its association with healthcare utilisation and long-term health outcomes: a multicentre cohort study Abstract Background Although the incidence of SARS‑CoV‑2 infections has declined, post‑COVID remains a major public health challenge...

Cognitive phenotypes and neuropsychological trajectories in post-COVID-19 syndrome: a 12-month follow-up study Abstract Post-COVID-19 syndrome (PCS) has been associated with cognitive difficulties, particularly in attention, processing speed, memory, and executive functions, but longitudinal...

Long-term prognostic value and clinical correlates of brain [¹⁸F]-FDG PET in patients with post-COVID-19 condition and neurocognitive disorders: a prospective cohort study Abstract Purpose: Brain [18F]-FDG-PET often reveals cerebral hypometabolism in post-COVID-19 patients experiencing...

Evaluating the longitudinal physical and psychological health effects of persistent long Covid 3.5 years after infection Abstract This is a 3.5-year single-center observational cohort study investigating the longitudinal impact of Long Covid on the physical and mental health of patients...

Neurocognitive trajectories in long COVID: Evidence from longitudinal analyses Highlights Brain fog or cognitive impairment is common after COVID-19, but the long-term trajectory is unknown. We used data from a large cohort of patients post-COVID-19, followed for 42 months. While cognition...

Cohort profile: Ngā Kawekawe o Mate Korona | Impacts of COVID-19 in Aotearoa – a prospective, national cohort study of people with COVID-19 in New Zealand Abstract Purpose The COVID-19 pandemic has had significant health, social and economic impacts around the world. We established a...

Five-year Quantitative Chest CT and Hyperpolarized Xenon 129 Ventilation MRI Findings in Survivors of COVID-19 Pneumonia Abstract Background Whether pulmonary sequelae persist 5 years after COVID-19 pneumonia remains unknown. Purpose To evaluate 5-year pulmonary abnormalities in survivors of...

Acute viral respiratory infections are not associated with an increased IMMune Age indeX (IMMAX) four weeks after infection: a prospective observational cohort study Abstract Background The factors that determine how quickly immunosenescence occurs in individuals are not yet fully understood...

Characteristics Associated With Persistent Long COVID Symptoms in Healthcare Personnel Infected With SARS‐CoV‐2 Between August 2022 and May 2024: A Multicenter Cohort Analysis of US Healthcare Personnel ABSTRACT Background Long COVID affects a significant proportion of COVID-19 survivors...

Sex-specific patterns of symptom burden, psychological distress, and work productivity impairment in post-acute sequelae of COVID-19: a 10-month dynamic cohort study Abstract Background A considerable proportion of patients experience post-acute sequelae of COVID-19 (PASC). Increasing...

Longitudinal epigenetic rewiring in lung immune cells in patients with post COVID-19 condition Abstract Background Post COVID-19 condition (PCC) is characterized by persistent, heterogeneous symptoms, most prominently affecting the cardiopulmonary system, yet its underlying biological...

Respiratory symptoms up to 18 months after COVID-19 – a longitudinal observational study Abstract Background This study aimed to identify, analyse and compare adults with and without respiratory symptoms over time after COVID-19 and identify predictors of persistent respiratory symptoms, in...

Clinical Phenotypes of Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection: A Longitudinal Cohort Study from Karachi, Pakistan Abstract Post Acute Sequelae of SARS CoV 2 infection, or PASC, is an emerging public health concern. Longitudinal data from South Asia remain limited and the burden...

Kinetics of the PASC Index in Long COVID Abstract Background The post‑acute sequelae of SARS‑CoV‑2 infection (PASC, “Long COVID”) remain difficult to evaluate because standardized diagnostic tools are limited. We applied the recently proposed PASC index (score ≥ 12) to describe the 12‑month...

Long COVID and risk of incident cardiovascular disease: a prospective cohort study using the Multimorbidity Integrated Registry Across Care Levels in Stockholm (MIRACLE-S) cohort Summary Background Long COVID has emerged as a global health challenge, with increasing evidence of cardiovascular...

Association between physical activity before SARS-CoV-2 infection and functional disability 24 months after COVID-19: findings from the SulCOVID-19 longitudinal study Abstract Background Individuals diagnosed with coronavirus disease 2019 (COVID-19), even those with mild illness, report...

Longitudinal trajectories of neurologic symptoms and cognitive associations at 36-months post-hospitalization for COVID-19 Abstract Background: A substantial proportion of individuals hospitalized for COVID 19 experience persistent neurological and psychiatric symptoms. The long-term...