magnetic resonance spectroscopy

Assessing Neuroinflammation in GWI Using MRS Sponsor: University of Alabama at Birmingham Principal Investigator: Jarred Younger Study Description This proposal is for a Tier 1 (Discovery) study that uses a human, cross-sectional, observational neuroimaging approach to measure...

I cam across this paper Apoptosis-induced mitochondrial dysfunction causes cytoplasmic lipid droplet formation A characteristic of apoptosis is the rapid accumulation of cytoplasmic lipid droplets, which are composed largely of neutral lipids. The proton signals from these lipids have been...

And yet here we are in 2023 . . . Summary A 34-year-old man affected by exercise intolerance, mild proximal weakness and severe lactic acidosis is described. Muscle biopsy revealed mitochondrial abnormalities and an increase of cytochrome c oxidase histochemical reaction. Biochemical...

Highlights Fibromyalgia (FM) may involve an overactive immune system. We used endotoxin to stimulate the immune system in women with FM. Magnetic resonance spectroscopy showed increased brain temperature in the thalamus. N-Acetylaspartate decreased in the left Rolandic operculum. FM patients...

Abstract (only): Exploring the Genetic Contribution to Oxidative Stress in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Nicholas Henry Hampilos1 , Arnaud Germain2 , Xiangling Mao1 , Maureen R. Hanson2 , Dikoma C. Shungu1 1 Weill Cornell Medicine 2 Cornell University...

Efficacy and tolerability of an endogenous metabolic modulator (AXA1125) in fatigue-predominant long COVID: a single-centre, double-blind, randomised controlled phase 2a pilot study Lucy E.M. Finnigan Mark Philip Cassar Margaret James Koziel Joel Pradines Hanan Lamlum Karim Azer et al...

Nuclear Magnetic Resonance Spectroscopy Metabolomics in Idiopathic Intracranial Hypertension to Identify Markers of Disease and Headache Grech O, Seneviratne SY, Alimajstorovic Z, Yiangou A, Mitchell JL, Smith TB, Mollan SP, Lavery GG, Ludwig C, Sinclair AJ Background and objective: We...

Dr Nina Rzechorzek, MRC Clinician Scientist Fellow from the MRC Laboratory for Molecular Biology who led the study, said: “Using the most comprehensive exploration to date of normal human brain temperature, we’ve established ‘HEATWAVE’ – a 4D temperature map of the brain. This map provides an...

Abstract Rationale Chronic fatigue syndrome (CFS) is a common and burdensome illness with a poorly understood pathophysiology, though many of the characteristic symptoms are likely to be of brain origin. The use of high-field proton magnetic resonance spectroscopy (MRS) enables the detection of...

Note that this is a study from 1998 and is posted for potential future reference. Abstract It has been shown previously that some patients with chronic fatigue syndrome show an abnormal increase in plasma lactate following a short period of moderate exercise, in the sub-anaerobic threshold...

Christina Mueller, Joanne C. Lin, Sulaiman Sheriff, Andrew A. Maudsley, Jarred W. Younger Behind a paywall https://link.springer.com/article/10.1007/s11682-018-0029-4