mcas

Abstract Background/Objectives: Growing evidence suggests that mast cell activation (MCA) may contribute to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a debilitating disorder characterized by persistent fatigue and post-exertional malaise (PEM). Particularly in relation to...

Abstract Background Hypermobility Spectrum Disorders (HSD) and hypermobile Ehlers-Danlos syndrome (h-EDS) are multisystemic connective tissue disorders involving joint hypermobility and numerous other manifestations. Autonomic dysfunction, chronic pain, and chronic fatigue are known...

https://www.mdpi.com/2075-1729/14/2/164 Abstract Histamine receptor antagonists, which can bind to specific histamine receptors on target cells, exhibit substantial therapeutic efficacy in managing a variety of histamine-mediated disorders. Notably, histamine H1 and H2 receptor antagonists...

Abstract: Mast cell activation (MCA) is seen in a variety of clinical contexts and pathologies, including IgE-dependent allergic inflammation, other immunologic and inflammatory reactions, primary mast cell (MC) disorders, and hereditary alpha tryptasemia (HAT). MCA-related symptoms range from...

3 Years Into Long COVID: Where Do We Go From Here? https://www.medscape.com/viewarticle/993827 "... approximately 6% of all US adults are currently experiencing long COVID, with Hispanic/Latinx individuals, transgender individuals, and cis female individuals facing the highest rates."...

Free fulltext: https://onlinelibrary.wiley.com/doi/full/10.1111/all.15304 Idiopathic mast cell activation syndrome is more often suspected than diagnosed—A prospective real-life study Thomas Buttgereit, Sophie Gu, Leonor Carneiro-Leão, Annika Gutsche, Marcus Maurer, Frank Siebenhaar First...

Wirth and Lohn Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is often associated with various other syndromes or conditions including mast cell activation (MCA), dysmenorrhea and endometriosis, postural tachycardia (POTS) and small fiber neuropathy (SFN). The causes of...

U.K. Where to buy pepcid/famotidine Hi all, we want to try famotidine as a treatment for Long Covid but I have discovered that Boots does not stock it, yet it seems to be an OTC medication in the UK (sold as Pepcid). Does anyone know where to buy it? Thank you

The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications Kell DB, Pretorius E Ischaemia-reperfusion (I-R) injury, initiated via bursts of reactive oxygen species...

Abstract Background Recently there has been increased interest in a possible association between mast cell activation (MCA) disorder and postural orthostatic tachycardia syndrome (POTS). This study examined the frequency with which symptoms and laboratory findings suggesting MCA disorder...

Abstract COVID‐19 leads to severe respiratory problems, but also to long‐COVID syndrome associated primarily with cognitive dysfunction and fatigue. Long‐COVID syndrome symptoms, especially brain fog, are similar to those experienced by patients undertaking or following chemotherapy for cancer...

Local immune response to food antigens drives meal-induced abdominal pain https://www.nature.com/articles/s41586-020-03118-2

This thread has been split from Concerns about craniocervical instability surgery in ME/CFS ....I know you have a lot of pull on here @Jonathan Edwards, but I didn't know you didn't believe in MCAS being a real diagnosis. As I live in the States, I have to say that there seem to be a lot of...

Free full text: https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2020/06/Mast-Cell-Activation-Syndrome-June-2020.pdf I haven't read this and have no idea whether it is good or not; it simply came up in a Google Scholar search result update I get for "chronic Fatigue syndrome"

Free full text: https://www.degruyter.com/view/journals/dx/ahead-of-print/article-10.1515-dx-2020-0005/article-10.1515-dx-2020-0005.xml

(I wasn't sure which forum to post this to). This is being promoted as being a relevance to people with ME. I haven't watched it and know very little if anything about this area.

Mast cell activation syndrome: Importance of consensus criteria and call for research, Valent, Peter et al. 2018, Journal of Allergy and Clinical Immunology, Volume 142, Issue 3, 1008 - 101, https://www.jacionline.org/article/S0091-6749(18)30854-6/fulltext (letter to the editor) I found this...

Dr. Peter Vadas - CME Presentation: Mast Cells Gone Wild - Mast Cell Activation Disorders First 20 minutes are an introduction and offsetting MCAS against mastocytosis. After that he focuses on the type of MCAS that overlaps with POTS and EDS, mentioning the following article: JJ Lyons et...

http://casereports.bmj.com/content/2018/bcr-2018-224689.long

Paywalled at https://www.karger.com/Article/Abstract/493531#tab4