microclots

Full title: The Effect on Quality of Life of Therapeutic Plasmapheresis and Intravenous Immunoglobulins on a Population of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients with Elevated β-Adrenergic and M3-Muscarinic Receptor Antibodies—A Pilot Study...

Abstract Background: Long COVID is a persistent and episodic multi-system condition that impacts quality of life and functional status. Underlying pathologies include viral persistence, endothelial dysfunction, platelet hyperactivation/dysregulation, and the presence of anomalous deposits, also...

Treatment of Long Covid with Enoxaparin, 2025, Wright, Ciara PhD, Kell, Douglas PhD, Pretorius, Resia PhD. Putrino, David PhD Abstract Background and Purpose: Long COVID is a complex multisystemic disease state, which represents a huge economic and health burden worldwide. Hypercoagulation and...

Now published: linked here Preprint Abstract In classical amyloidoses, amyloid fibres form through the nucleation and accretion of protein monomers, with protofibrils and fibrils exhibiting a cross-beta motif of parallel or antiparallel beta-sheets oriented perpendicular to the fibre...

Circulating microclots are structurally associated with Neutrophil Extracellular Traps and their amounts are strongly elevated in long COVID patients Etheresia Pretorius¹, Alain THIERRY², Cynthia Sanchez³, Tram Ha⁴, Brice Pastor⁴, Alexia Mirandola³, Ekaterina Pisareva⁵, Corinne Prevostel⁶, Gert...

Posting this not about the scientific arguments about microclots, which we have discussed in the individual papers, but more about their experiences in interacting with Cochrane. Note the below link from Doug Kell's blog is from a non-secured server (http not https) and the page formatting is...

Abstract Platelet-rich plasma (PRP) commonly refers to blood products which contain a higher platelet (PLT) concentration as compared to normal plasma. Autologous PRP has been shown to be safe and effective in promoting the natural processes of soft tissue healing or reconstruction in humans and...

Interventional Removal of Travelling Microthrombi Using Targeted Magnetic Microbubble Yongjian Li; Zujie Gao; Xiaobing Zheng; Yunfan Pan; Jinlong Xu; Yan Li; Haosheng Chen Microthrombus is one of the major causes of the sequelae of COVID-19 and leads to subsequent embolism and necrosis. Due to...

https://www.researchsquare.com/article/rs-4507472/v1 Article Flow Clotometry: Measuring Amyloid Microclots in ME/CFS, Long COVID, and Healthy Samples with Imaging Flow Cytometry Etheresia Pretorius Stellenbosch University Massimo Nunes Stellenbosch University Jan pretorius Douglas Kell...

Evidence Circulating Microclots and Activated Platelets Contribute to Hyperinflammation Within Pediatric Post Acute Sequala of COVID https://www.atsjournals.org/doi/10.1164/ajrccm-conference.2024.209.1_MeetingAbstracts.A2247

Abstract: People with the post-COVID-19 condition suffer symptoms that persist beyond 12 weeks following acute COVID-19 infection. Fatigue, shortness of breath, and cognitive dysfunction (“brain fog”) are common. Scientists, clinicians, and patients debate the pathophysiology. One...

Circulating microaggregates as biomarkers for the Post‐COVID syndrome Hermann; Lisch; Gerth; Wick; Fries; Wick CoVID-19 can develop into Post-COVID syndrome of potentially high morbidity, with procoagulation and reactivation of dormant viral infections being hypothesized pathophysiological...

Fibrinaloid Microclots and Atrial Fibrillation Kell, Douglas B.; Lip, Gregory Y. H.; Pretorius, Etheresia Atrial fibrillation (AF) is a comorbidity of a variety of other chronic, inflammatory diseases for which fibrinaloid microclots are a known accompaniment (and in some cases, a cause, with a...

Amyloid-Fibrinogen Aggregates Microclots Predict Risks of Disseminated Intravascular Coagulation and Mortality Schofield, Jeremy; Abrams, Simon Timothy; Jenkins, Rosalind; Lane, Steven; Wang, Guozheng; Toh, Cheng-Hock Microclots have been associated with various conditions, including post-acute...

Longitudinal viscosity of blood plasma for rapid COVID-19 prognostics Jennifer Illibauer; Tamara Clodi-Seitz; Alexander Zoufaly; Judith H Aberle; Wolfgang J Weninger; Manuela Foedinger; Kareem Elsayad Blood Plasma Viscosity (PV) is an established biomarker for numerous diseases. While PV...

Abstract A 45-year-old male with diabetes, hypertension and hyperlipidemia was referred to urology due to persistent symptoms of urinary frequency, urgency, nocturia, erectile dysfunction, and constant pain localized to the bladder, pelvis, and perineal area, 3–4 months after SARS-CoV-2...

Digital holo-tomographic 3D maps of COVID-19 microclots in blood to assess disease severity Abstract The coronavirus disease 2019 (COVID-19) has impacted health globally. Cumulative evidence points to long-term effects of COVID-19 such as cardiovascular and cognitive disorders diagnosed in...

A novel flow cytometric method for detecting fibrin(ogen) amyloid microclots using long COVID as a model HIGHLIGTS Imaging flow cytometry utilizing a novel rapid flow cytometric detection method is a promising method for detecting amyloid fibrin(ogen) microclots in conditions associated with...

Plasma from patients with pulmonary embolism show aggregates that reduce after anticoagulation Baker, Stephen R.; Halliday, Georgia; Ząbczyk, Michal; Alkarithi, Ghadir; Macrae, Fraser L.; Undas, Anetta; Hunt, Beverley J.; Ariëns, Robert A. S. Background Microclots, a term also used for amyloid...

Uncertainties about the Roles of Anticoagulation and Microclots in Post-acute Sequelae of SARS-CoV-2 Infection Jean M. Connors; Robert A.S. Ariëns Three years after the start of the pandemic, approaches to the prevention and treatment of acute Covid-19 have been established. However, post-acute...