microclots

Plasmapheresis to remove amyloid fibrin(ogen) particles for treating the post‐COVID‐19 condition Background The post‐COVID‐19 condition (PCC) consists of a wide array of symptoms including fatigue and impaired daily living. People seek a wide variety of approaches to help them recover. A...

Pulmonary circulation abnormalities in post-acute COVID-19 syndrome: dual-energy CT angiographic findings in 79 patients Mohamed, Islam; de Broucker, Virginie; Duhamel, Alain; Giordano, Jessica; Ego, Alice; Fonne, Nicolas; Chenivesse, Cécile; Remy, Jacques; Remy-Jardin, Martine Objectives To...

Abstract Long COVID has become a significant global health and economic burden, yet there are currently no established diagnostic tools to identify which patients might benefit from specific treatments. One of the major pathophysiological factors contributing to Long COVID is the presence of...

Analysis of thrombogenicity under flow reveals new insights into the prothrombotic state of patients with post-COVID syndrome Adela Constantinescu-Bercu, Anna Kessler, Rens de Groot, Bertina Dragunaite, Melissa Heightman, Toby Hillman, Laura C. Price, Ewan Brennan, Raphael Sivera, Karen...

LONG COVID, ME/CFS, FM, APS: VENOUS BLOOD GASES MEASUREMENT FOR THE DIAGNOSTICS OF HYPOXEMIA, HYPOPERFUSION, HYPERCOAGULABILITY AND MICROCLOTS IN DISEASES AND SYNDROMES PRESENTING CHRONIC FATIGUE AND BRAIN FOG. preprint Abstract LONG COVID, ME/CFS, FM, APS: VENOUS BLOOD GASES MEASUREMENT FOR...

https://www.medrxiv.org/content/10.1101/2022.10.13.22281055v1 News article on the study https://www.news-medical.net/news/20221018/New-research-finds-microclotting-and-inflammatory-molecule-abnormalities-in-long-COVID.aspx

Abstract Background Post-acute sequelae of COVID-19 (PASC), also now known as long COVID, has become a major global health and economic burden. Previously, we provided evidence that there is a significant insoluble fibrin amyloid microclot load in the circulation of individuals with long COVID...

The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications Kell DB, Pretorius E Ischaemia-reperfusion (I-R) injury, initiated via bursts of reactive oxygen species...

Relative hypercoagulopathy of the SARS-CoV-2 Beta and Delta variants when compared to the less severe Omicron variants is related to TEG parameters, the extent of fibrin amyloid microclots, and the severity of clinical illness. Abstract: Earlier variants of SARS-CoV-2 have been associated with...

Abstract Background Fibrin(ogen) amyloid microclots and platelet hyperactivation previously reported as a novel finding in South African patients with the coronavirus 2019 disease (COVID-19) and Long COVID/Post-Acute Sequelae of COVID-19 (PASC), might form a suitable set of foci for the clinical...

Neurovascular injury with complement activation and inflammation in COVID-19 Myoung-Hwa Lee, Daniel P. Perl, Joseph Steiner, Nicholas Pasternack, Wenxue Li, Dragan Maric, Farinaz Safavi, Iren Horkayne-Szakaly, Robert Jones, Michelle N. Stram, Joel T. Moncur, Marco Hefti, Rebecca D. Folkerth...

Note - from 2006 https://pubmed.ncbi.nlm.nih.gov/16479189/ Abstract Chronic fatigue syndrome (CFS) is a debilitating condition that has no known aetiology or pathophysiology. Recent investigations by other workers have suggested that individuals with CFS may have a hypercoagulable state. This...

Abstract We have previously demonstrated that platelet poor plasma (PPP) obtained from patients with LongCovid/Post-Acute Sequelae of COVID-19 (PASC) is characterized by a hypercoagulable state reflected in hyperactivated platelets and the presence of considerable numbers of fibrin(ogen) amyloid...

Amyloidogenesis of SARS-CoV-2 Spike Protein Sofie Nyström, Per Hammarström Abstract SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and...

A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications Douglas B. Kell, Gert Jacobus Laubscher and Etheresia Pretorius Post-acute sequelae of COVID (PASC), usually referred to as ‘Long COVID’ (a phenotype of COVID-19), is a relatively frequent...

Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting Douglas Kell and Etheresia Pretorius Abstract The chief and largely terminal element of normal blood clotting is...

Combined triple treatment of fibrin amyloid microclots and platelet pathology in individuals with Long COVID/ Post-Acute Sequelae of COVID-19 (PASC) can resolve their persistent symptoms Etheresia Pretorius, Chantelle Venter, Gert Laubshder, Maritha Kotze, Kelebogile Moremi, Sunday Oladejo...

SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19 Lize M. Grobbelaar, Chantelle Venter, Mare Vlok, Malebogo Ngoepe, Gert Jacobus Laubscher, Petrus Johannes Lourens, Janami Steenkamp, Douglas B. Kell and Etheresia...

Full title: CFS/ME, FM: “THERAPEUTIC TEST” AND FIRST TREATMENT SCHEME FOR PATIENTS WITH CHRONIC FATIGUE AND BRAIN FOG TO ASSIST THE DIAGNOSIS OF PERSISTENT CLOTS AND HYPOPERFUSION. For patients with Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Fibromyalgia, Persistent Symptoms of COVID...