microclots

Evidence Circulating Microclots and Activated Platelets Contribute to Hyperinflammation Within Pediatric Post Acute Sequala of COVID https://www.atsjournals.org/doi/10.1164/ajrccm-conference.2024.209.1_MeetingAbstracts.A2247

Abstract: People with the post-COVID-19 condition suffer symptoms that persist beyond 12 weeks following acute COVID-19 infection. Fatigue, shortness of breath, and cognitive dysfunction (“brain fog”) are common. Scientists, clinicians, and patients debate the pathophysiology. One...

Circulating microaggregates as biomarkers for the Post‐COVID syndrome Hermann; Lisch; Gerth; Wick; Fries; Wick CoVID-19 can develop into Post-COVID syndrome of potentially high morbidity, with procoagulation and reactivation of dormant viral infections being hypothesized pathophysiological...

Fibrinaloid Microclots and Atrial Fibrillation Kell, Douglas B.; Lip, Gregory Y. H.; Pretorius, Etheresia Atrial fibrillation (AF) is a comorbidity of a variety of other chronic, inflammatory diseases for which fibrinaloid microclots are a known accompaniment (and in some cases, a cause, with a...

Amyloid-Fibrinogen Aggregates Microclots Predict Risks of Disseminated Intravascular Coagulation and Mortality Schofield, Jeremy; Abrams, Simon Timothy; Jenkins, Rosalind; Lane, Steven; Wang, Guozheng; Toh, Cheng-Hock Microclots have been associated with various conditions, including post-acute...

Longitudinal viscosity of blood plasma for rapid COVID-19 prognostics Jennifer Illibauer; Tamara Clodi-Seitz; Alexander Zoufaly; Judith H Aberle; Wolfgang J Weninger; Manuela Foedinger; Kareem Elsayad Blood Plasma Viscosity (PV) is an established biomarker for numerous diseases. While PV...

Abstract A 45-year-old male with diabetes, hypertension and hyperlipidemia was referred to urology due to persistent symptoms of urinary frequency, urgency, nocturia, erectile dysfunction, and constant pain localized to the bladder, pelvis, and perineal area, 3–4 months after SARS-CoV-2...

Digital holo-tomographic 3D maps of COVID-19 microclots in blood to assess disease severity Abstract The coronavirus disease 2019 (COVID-19) has impacted health globally. Cumulative evidence points to long-term effects of COVID-19 such as cardiovascular and cognitive disorders diagnosed in...

A novel flow cytometric method for detecting fibrin(ogen) amyloid microclots using long COVID as a model HIGHLIGTS Imaging flow cytometry utilizing a novel rapid flow cytometric detection method is a promising method for detecting amyloid fibrin(ogen) microclots in conditions associated with...

Plasma from patients with pulmonary embolism show aggregates that reduce after anticoagulation Baker, Stephen R.; Halliday, Georgia; Ząbczyk, Michal; Alkarithi, Ghadir; Macrae, Fraser L.; Undas, Anetta; Hunt, Beverley J.; Ariëns, Robert A. S. Background Microclots, a term also used for amyloid...

Uncertainties about the Roles of Anticoagulation and Microclots in Post-acute Sequelae of SARS-CoV-2 Infection Jean M. Connors; Robert A.S. Ariëns Three years after the start of the pandemic, approaches to the prevention and treatment of acute Covid-19 have been established. However, post-acute...

Plasmapheresis to remove amyloid fibrin(ogen) particles for treating the post‐COVID‐19 condition Background The post‐COVID‐19 condition (PCC) consists of a wide array of symptoms including fatigue and impaired daily living. People seek a wide variety of approaches to help them recover. A...

Pulmonary circulation abnormalities in post-acute COVID-19 syndrome: dual-energy CT angiographic findings in 79 patients Mohamed, Islam; de Broucker, Virginie; Duhamel, Alain; Giordano, Jessica; Ego, Alice; Fonne, Nicolas; Chenivesse, Cécile; Remy, Jacques; Remy-Jardin, Martine Objectives To...

Abstract Long COVID has become a significant global health and economic burden, yet there are currently no established diagnostic tools to identify which patients might benefit from specific treatments. One of the major pathophysiological factors contributing to Long COVID is the presence of...

Analysis of thrombogenicity under flow reveals new insights into the prothrombotic state of patients with post-COVID syndrome Adela Constantinescu-Bercu, Anna Kessler, Rens de Groot, Bertina Dragunaite, Melissa Heightman, Toby Hillman, Laura C. Price, Ewan Brennan, Raphael Sivera, Karen...

LONG COVID, ME/CFS, FM, APS: VENOUS BLOOD GASES MEASUREMENT FOR THE DIAGNOSTICS OF HYPOXEMIA, HYPOPERFUSION, HYPERCOAGULABILITY AND MICROCLOTS IN DISEASES AND SYNDROMES PRESENTING CHRONIC FATIGUE AND BRAIN FOG. preprint Abstract LONG COVID, ME/CFS, FM, APS: VENOUS BLOOD GASES MEASUREMENT FOR...

https://www.medrxiv.org/content/10.1101/2022.10.13.22281055v1 News article on the study https://www.news-medical.net/news/20221018/New-research-finds-microclotting-and-inflammatory-molecule-abnormalities-in-long-COVID.aspx

Abstract Background Post-acute sequelae of COVID-19 (PASC), also now known as long COVID, has become a major global health and economic burden. Previously, we provided evidence that there is a significant insoluble fibrin amyloid microclot load in the circulation of individuals with long COVID...

The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications Kell DB, Pretorius E Ischaemia-reperfusion (I-R) injury, initiated via bursts of reactive oxygen species...

Relative hypercoagulopathy of the SARS-CoV-2 Beta and Delta variants when compared to the less severe Omicron variants is related to TEG parameters, the extent of fibrin amyloid microclots, and the severity of clinical illness. Abstract: Earlier variants of SARS-CoV-2 have been associated with...