microclots

Neurovascular injury with complement activation and inflammation in COVID-19 Myoung-Hwa Lee, Daniel P. Perl, Joseph Steiner, Nicholas Pasternack, Wenxue Li, Dragan Maric, Farinaz Safavi, Iren Horkayne-Szakaly, Robert Jones, Michelle N. Stram, Joel T. Moncur, Marco Hefti, Rebecca D. Folkerth...

Note - from 2006 https://pubmed.ncbi.nlm.nih.gov/16479189/ Abstract Chronic fatigue syndrome (CFS) is a debilitating condition that has no known aetiology or pathophysiology. Recent investigations by other workers have suggested that individuals with CFS may have a hypercoagulable state. This...

Abstract We have previously demonstrated that platelet poor plasma (PPP) obtained from patients with LongCovid/Post-Acute Sequelae of COVID-19 (PASC) is characterized by a hypercoagulable state reflected in hyperactivated platelets and the presence of considerable numbers of fibrin(ogen) amyloid...

Amyloidogenesis of SARS-CoV-2 Spike Protein Sofie Nyström, Per Hammarström Abstract SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and...

A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications Douglas B. Kell, Gert Jacobus Laubscher and Etheresia Pretorius Post-acute sequelae of COVID (PASC), usually referred to as ‘Long COVID’ (a phenotype of COVID-19), is a relatively frequent...

Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting Douglas Kell and Etheresia Pretorius Abstract The chief and largely terminal element of normal blood clotting is...

Combined triple treatment of fibrin amyloid microclots and platelet pathology in individuals with Long COVID/ Post-Acute Sequelae of COVID-19 (PASC) can resolve their persistent symptoms Etheresia Pretorius, Chantelle Venter, Gert Laubshder, Maritha Kotze, Kelebogile Moremi, Sunday Oladejo...

SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19 Lize M. Grobbelaar, Chantelle Venter, Mare Vlok, Malebogo Ngoepe, Gert Jacobus Laubscher, Petrus Johannes Lourens, Janami Steenkamp, Douglas B. Kell and Etheresia...

Full title: CFS/ME, FM: “THERAPEUTIC TEST” AND FIRST TREATMENT SCHEME FOR PATIENTS WITH CHRONIC FATIGUE AND BRAIN FOG TO ASSIST THE DIAGNOSIS OF PERSISTENT CLOTS AND HYPOPERFUSION. For patients with Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Fibromyalgia, Persistent Symptoms of COVID...

Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19 Nishikawa, M., Kanno, H., Zhou, Y. et al. Abstract A characteristic clinical feature of COVID-19 is the frequent incidence of microvascular thrombosis. In fact, COVID-19...

Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation Martin J. Page, Greig J. A. thomson, J. Massimo Nunes, Anna-Mart Engelbrecht, Theo A Nell, Willem J. S. de Villiers, Maria C. de Beer, Lize Engelbrecht, Douglas B. Kell, Etheresia Pretorius Abstract Complex associations...

Posts copied from The micro-clot finding in Long Covid — implications for the possible aetiology of ME/CFS...

Thread split from The micro-clot finding in Long Covid — implications for the possible aetiology of ME/CFS ***************** https://www.nature.com/articles/s41380-021-01148-4 Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis? 2021

Moved from Six-month sequelae of post-vaccination SARS-CoV-2 infection: a retrospective cohort study of 10,024 breakthrough infections, 2021, Taquet et al @Hutan thank you, I believe it's all coming together and Long Covid will have been instrumental. The Pretorius micro-clot finding is...

Abstract Background Persistent symptoms including breathlessness, fatigue and decreased exercise tolerance have been reported in patients after acute SARS-CoV-2 infection. The biological mechanisms underlying this ‘Long COVID’ syndrome remain unknown. However, autopsy studies have highlighted...