microglial activation

An emergent disease-associated motor neuron state precedes cell death in ALS To define molecular determinants of motor neuron degeneration in amyotrophic lateral sclerosis (ALS), we generated longitudinal single-nucleus transcriptomes and chromatin accessibility profiles of spinal motor...

Association between post-COVID-19 neuropsychiatric symptoms and persistent glial activation in the limbic system: a TSPO PET study Background A subset of individuals experience prolonged neurological and psychiatric symptoms following SARS-CoV-2 infection, a condition referred to as long...

Inflammation from mild COVID-19 results in persistent neurological and behavioral changes in rhesus macaques Although most SARS-CoV-2 infections result in mild or moderate symptoms not requiring hospitalization, many patients experience persistent symptoms after their initial recovery, a...

Microglial Activation in Nociplastic Pain: From Preclinical Models to PET Neuroimaging and Implications for Targeted Therapeutic Strategies Nociplastic pain has recently been introduced as a third entity for identifying patients suffering from chronic pain that arises from altered nociception...

Underlying cause of Gulf War illness confirmed Link to research: Decadelong low basal ganglia NAA/tCr from elevated tCr supports ATP depletion from mitochondrial dysfunction and neuroinflammation in Gulf War illness

PET Imaging of Innate Immune Activation Using 11C Radiotracers Targeting GPR84 Chronic innate immune activation is a key hallmark of many neurological diseases and is known to result in the upregulation of GPR84 in myeloid cells (macrophages, microglia, and monocytes). As such, GPR84 can...

Crosstalk Among Disrupted Blood-Brain Barrier, Neuroinflammation, and Coagulopathy in AC70 hACE2 Tg Mice with Prolonged Neurological Manifestations Induced by the Omicron BA.1 Variant of SARS-CoV-2 Aleksandra K Drelich; Panatda Saenkham-Huntsinger; Yu-Hsiu E. Wang; Xuping Xie; Barbara M. Judy...

Long COVID elevated MMP-9 and release from microglia by SARS-CoV-2 Spike protein Duraisamy Kempuraj; Irene Tsilioni; Kristina K. Aenlle; Nancy G. Klimas; Theoharis C. Theoharides OBJECTIVES Long COVID is a major health concern because many patients develop chronic neuropsychiatric symptoms, but...

The S1 subunits of SARS-CoV-2 variants differentially trigger the IL-6 signaling pathway in human brain endothelial cells and downstream impact on microglia activation Michael Stangis; Daniel Adesse; Bhavya Sharma; Eduardo Castro; Kush Kumar; Neil Kumar; Masha Minevich; Michal Toborek...

The Human Microglia Atlas HuMicA Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative Conditions Ricardo Martins-Ferreira; Josep Calafell-Segura; Barbara Leal; Javier Rodriguez-Ubreva; Elisabetta Mereu; Paulo Pinho e Costa; Esteban Ballestar...