mitochondria

A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease Mitophagy is a fundamental quality control mechanism of mitochondria. Its regulatory mechanisms and pathological implications remain poorly understood. Here, via...

DecodeME candidate ME/CFS gene ******************** FBXL4 (Tier 2) • Protein: F-box/LRR-repeat protein 4. UniProt. GeneCards. • Molecular function: Component of the mitochondria-localised SCF-FBXL4 ubiquitin E3 ligase complex. This complex restricts mitophagy by controlling the degradation...

Metabolic adaptation and fragility in healthy 3-D in vitro skeletal muscle tissues exposed to Chronic Fatigue Syndrome and Long COVID-19 sera. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID-19 (LC-19) are complex conditions with no diagnostic markers or consensus on...

The Roles of Lactate and Lactylation in Diseases Related to Mitochondrial Dysfunction Ma, Fei; Yu, Wei Glycolysis and oxidative phosphorylation are the main pathways of cellular energy production. Glucose is metabolized via glycolysis to generate pyruvate, which, under anaerobic conditions, is...

https://interestingengineering.com/health/brain-healing-nanoflowers-treatment :emoji_rosette:

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox Laura F. DiGiovanni; Prabhsimran K. Khroud; Ruth E. Carmichael; Tina A. Schrader; Shivneet K. Gill; Kyla Germain; Robert Y. Jomphe; Christoph Wiesinger; Maxime Boutry; Maki Kamoshita; Daniel Snider; Garret Stubbings...

Abstract The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in widespread morbidity and mortality, with a significant portion of the affected population experiencing long-term health complications. This review explores the mechanisms of mitochondrial dysfunction in both the acute and...

Endothelial TERT drives microvascular phenotype associated with coronary artery disease Erin C. Birch; Yoshinori Nishijima; Shelby N. Hader; Andreas M. Beyer Microvascular endothelial dysfunction is a powerful predictor of future atherosclerotic cardiac events. Our previous studies revealed...

https://www.preprints.org/manuscript/202507.0058/v1 Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating, multi-system disease characterized by profound fatigue, post-exertional malaise (PEM), and a constellation of immune, neurological, and autonomic symptoms...

Electron-Microscopic Investigation of Muscle Mitochondria in Chronic Fatigue Syndrome Audrius V. Plioplys; Sigita Plioplys Abstract Patients with chronic fatigue syndrome (CFS) suffer from disabling physical and mental fatigue. Abnormalities in mitochondrial function can lead to fatigue and...

IFNγ causes mitochondrial dysfunction and oxidative stress in myositis Catalina Abad, Iago Pinal-Fernandez, Clement Guillou, Gwladys Bourdenet, Laurent Drouot, Pascal Cosette, Margherita Giannini, Lea Debrut, Laetitia Jean, Sophie Bernard, Damien Genty, Rachid Zoubairi, Isabelle Remy-Jouet...

Mitochondrial innate immune signaling in skeletal muscle adaptation to exercise Jin Ma; Annie Yujin Son; Youlim Son; Ping-yuan Wang; Paul M. Hwang Exercise-induced inflammation is regarded as a response to muscle damage from mechanical stress, but controlled immune signaling can be beneficial...

Indistinguishable mitochondrial phenotypes after exposure of healthy myoblasts to myalgic encephalomyelitis or control serum Audrey A. Ryback, Charles Hillier, Camila M Loureiro, Chris P Ponting, Caroline F Dalton Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome is a disease of...

https://www.mdpi.com/1422-0067/26/11/5339# Open Access Article Heat vs. Fatigue: Hyperthermia as a Possible Treatment Option for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) by Barbara Hochecker 1,*, Katja Matt 1, Melanie Scherer 1, Alica Meßmer 1, Alexander von Ardenne 2...

Natural polyphenol boosts mitochondrial function and muscle performance during aging I recently started taking olive leaf extract for quite different reasons before I found this, so it will be interesting to see if it has any other beneficial effects.

Regulation of synaptic mitochondria by extracellular vesicles and its implications for neuronal metabolism and synaptic plasticity Yuzhou Zeng; Anna Antoniou Mitochondrial metabolism in neurons is necessary for energetically costly processes like synaptic transmission and plasticity. As...

A human brain map of mitochondrial respiratory capacity and diversity Mosharov, Eugene V.; Rosenberg, Ayelet M.; Monzel, Anna S.; Osto, Corey A.; Stiles, Linsey; Rosoklija, Gorazd B.; Dwork, Andrew J.; Bindra, Snehal; Junker, Alex; Zhang, Ya; Fujita, Masashi; Mariani, Madeline B.; Bakalian...

Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19 Ronaldo Lira-Junior; Anoop Ambikan; Axel Cederholm; Ssefanit Rezene; Flora Mikaeloff; Sara Svensson Akusjarvi; Ahmet Yalcinkaya; Xi Chen; Maike Sperk...

POLG diseases: Rare genetic conditions that starve cells of energy and afflicted the late Prince of Luxembourg

Hi all! I'm a graduate student living with ME/CFS and currently studying ME/CFS and long COVID. I was recently reviewing literature on mitochondrial dysfunction and stumbled onto something very interesting which potentially explains several semi-consistent findings in the literature...