mitochondria

Highlights • SARS-CoV-2 ORF7a drives glycolytic and mitochondrial rewiring • The accessory protein ORF7a induces PDK4 and restricts pyruvate oxidation • Mitochondrial complex I activity is selectively impaired by ORF7a • ORF7a disrupts respiratory supercomplex assembly and redox balance Summary...

Case Report: Mitochondrial insufficiency underlies cholinergic failure in post-vaccination long COVID: a candidate treatment protocol Goulding, Tom Abstract An 80-year-old male with severe long COVID developed acute deterioration following COVID-19 vaccination despite ongoing cholinergic...

Altered TRPM3-Dependent Cytosolic and Mitochondrial Calcium Influx in Natural Killer Cells of Post-COVID-19 Condition Patients According to the World Health Organization (WHO), approximately 6% of COVID-19 cases develop serious long-term sequelae referred to as post-COVID-19 condition (PCC)...

Small extracellular vesicles proteome reveals persistent inflammatory and coagulopathic dysregulation in long-COVID Background Post-acute sequelae of SARS-CoV-2 (PASC) or Long-COVID affects millions and remains mechanistically undefined due to its heterogeneous clinical presentation...

Abstract Life on Earth has evolved in a form suitable for the gravitational force. Although the pivotal role of gravity in gene expression has been suggested, the molecular details remain unclear. Here, we show that mitochondria utilize gravity to activate protein synthesis within the organelle...

Immunothrombosis in hospitalized COVID-19 patients identified by multiomics profiling and linked to postacute complications Post-acute sequelae of COVID-19 (PASC) disproportionately affect hospitalized patients and require improved molecular characterization to inform patient management...

Plasma Extracellular Vesicle Surface Marker Profiling Reveals Immune Cell–Associated Mitochondrial Membrane Potential Alterations in Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome BACKGROUND Long COVID (LC) is characterized by symptoms persisting at least 3 months after...

Advancing understanding of long COVID pathophysiology through quantum walk-based network analysis MOTIVATION Long COVID is a multisystem condition characterized by persistent symptoms such as fatigue, cognitive impairment, and systemic inflammation following COVID-19 infection. However, its...

Multi-System Genetic Architecture of Hypermobile Ehlers–Danlos Syndrome: Integrating Machine Learning with Subject-Level Genomic Analysis BACKGROUND/OBJECTIVES Hypermobile Ehlers–Danlos syndrome (hEDS) remains genetically unexplained despite decades of clinical investigation, with the...

Systematic Examination of Gene Expression and Proteomic Evidence Across Tissues Supports the Role of Mitochondrial Dysregulation in ME/CFS Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, multisystem disease characterized by post-exertional malaise and...

Abstract: Persistent mitochondrial inflexibility and mitochondrial damage may contribute to Post-Acute Sequelae of COVID-19 (PASC). However, data linking mitochondrial biomarkers, such as circulating cell-free mitochondrial DNA (ccf-mtDNA) to long-COVID symptoms remain limited. We analyzed...

Full title: Chronic Fatigue Syndrome Induced by Environmental Toxic Exposure: Effects of Polyhexamethyleneguanidine Phosphate Exposure on Mitochondrial Function and Neural Health. Highlights PHMG-p contributes to CFS by inducing mitochondrial and neurological dysfunction. HD exposure has...

Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS Abstract In the past two decades, emerging studies have suggested that DExD/H box helicases belonging to helicase superfamily 2 (SF2) play essential roles in antiviral innate immunity...

Mitochondrial dysfunctions in Myalgic Encephalomyelitis / chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways 2013 Abstract Myalgic encephalomyelitis / chronic fatigue syndrome (ME/cfs) is classified by the World Health Organization as...

Abstract Primary sensory neurons in dorsal root ganglia (DRG) have long axons and a high demand for mitochondria, and mitochondrial dysfunction has been implicated in peripheral neuropathy after diabetes and chemotherapy1,2. However, the mechanisms by which primary sensory neurons maintain their...

Post-COVID impairment of memory T cell responses to community-acquired pathogens can be rectified by activating cellular metabolism Infection rates involving bacterial and viral pathogens have increased precipitously after the COVID-19 pandemic. While it has been speculated that higher...

Omics-based computational approaches for biomarker identification, prediction, and treatment of Long COVID Long COVID, or post-acute sequelae of COVID-19 (PASC), is a major global health problem, with cumulative estimates suggesting that around 400 million people worldwide have been affected...

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender Excessive exercise impairs cognitive function, but the underlying mechanism remains unclear. Here, we show that excessive vigorous exercise-induced lactate accumulation stimulates muscles to...

Extracellular vesicles from long COVID patients promote RUNX2-mediated cellular stress via dysregulated miR-204 and p53 pathway activation [Line breaks added] Background: Subjects with Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC)...

Underlying cause of Gulf War illness confirmed Link to research: Decadelong low basal ganglia NAA/tCr from elevated tCr supports ATP depletion from mitochondrial dysfunction and neuroinflammation in Gulf War illness