mitochondria

  1. SNT Gatchaman

    A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease, 2023, Cao+

    A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease Mitophagy is a fundamental quality control mechanism of mitochondria. Its regulatory mechanisms and pathological implications remain poorly understood. Here, via...
  2. Hutan

    Genetics: Chromosome 6 FBXL4

    DecodeME candidate ME/CFS gene ******************** FBXL4 (Tier 2) • Protein: F-box/LRR-repeat protein 4. UniProt. GeneCards. • Molecular function: Component of the mitochondria-localised SCF-FBXL4 ubiquitin E3 ligase complex. This complex restricts mitophagy by controlling the degradation...
  3. Dolphin

    Metabolic adaptation and fragility in healthy 3-D in vitro skeletal muscle tissues exposed to [CFS] and Long COVID-19 sera, 2025, Mughal+

    Preliminary abstract, see post #13 for final paper. ----------------- https://www.sciencedirect.com/science/article/abs/pii/S0960896624003353 571P Muscular metabolic plasticity in 3D in vitro models against systemic stress factors in ME/CFS and long COVID-19 Author links 1 Institute For...
    • Dolphin
    • Thread
    • calcium drp1 glycolysis mitochondria mitochondrial morphology muscle muscle fatigability oxygen use pdk4 serum something in the blood
    • Replies: 65
    • Forum: ME/CFS research
  4. SNT Gatchaman

    Review The Roles of Lactate and Lactylation in Diseases Related to Mitochondrial Dysfunction, 2025, Fei and Yu

    The Roles of Lactate and Lactylation in Diseases Related to Mitochondrial Dysfunction Ma, Fei; Yu, Wei Glycolysis and oxidative phosphorylation are the main pathways of cellular energy production. Glucose is metabolized via glycolysis to generate pyruvate, which, under anaerobic conditions, is...
  5. Sly Saint

    Article: Metallic nanoflowers heal brain cells and extend lifespan in stunning new research

    https://interestingengineering.com/health/brain-healing-nanoflowers-treatment :emoji_rosette:
  6. SNT Gatchaman

    ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox, 2025, DiGiovanni et al.

    ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox Laura F. DiGiovanni; Prabhsimran K. Khroud; Ruth E. Carmichael; Tina A. Schrader; Shivneet K. Gill; Kyla Germain; Robert Y. Jomphe; Christoph Wiesinger; Maxime Boutry; Maki Kamoshita; Daniel Snider; Garret Stubbings...
  7. Wyva

    Review Mitochondrial dysfunction in acute and post-acute phases of COVID-19 and risk of non-communicable diseases, 2024, Borland Madsen et al

    Abstract The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in widespread morbidity and mortality, with a significant portion of the affected population experiencing long-term health complications. This review explores the mechanisms of mitochondrial dysfunction in both the acute and...
  8. SNT Gatchaman

    Endothelial TERT drives microvascular phenotype associated with coronary artery disease, 2025, Birch et al.

    Endothelial TERT drives microvascular phenotype associated with coronary artery disease Erin C. Birch; Yoshinori Nishijima; Shelby N. Hader; Andreas M. Beyer Microvascular endothelial dysfunction is a powerful predictor of future atherosclerotic cardiac events. Our previous studies revealed...
    • SNT Gatchaman
    • Thread
    • acetylcholine coronary arteries endothelial dysfunction microcirculation mitochondria nitric oxide telomerase telomerase reverse transcriptase
    • Replies: 0
    • Forum: Other health news and research
  9. John Mac

    Review Redefining Mitochondrial Therapy for ME/CFS: The Case for MOTS-c, 2025, Klimas et al

    https://www.preprints.org/manuscript/202507.0058/v1 Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating, multi-system disease characterized by profound fatigue, post-exertional malaise (PEM), and a constellation of immune, neurological, and autonomic symptoms...
    • John Mac
    • Thread
    • ampk mdps me/cfs mitochondria mitochondria derived peptides nancy klimas
    • Replies: 21
    • Forum: ME/CFS research
  10. jnmaciuch

    Electron-Microscopic Investigation of Muscle Mitochondria in Chronic Fatigue Syndrome, 1995, Plioplys & Plioplys

    Electron-Microscopic Investigation of Muscle Mitochondria in Chronic Fatigue Syndrome Audrius V. Plioplys; Sigita Plioplys Abstract Patients with chronic fatigue syndrome (CFS) suffer from disabling physical and mental fatigue. Abnormalities in mitochondrial function can lead to fatigue and...
    • jnmaciuch
    • Thread
    • electron microscopy mitochondria mitochondrial morphology muscle biopsy
    • Replies: 5
    • Forum: ME/CFS research
  11. jnmaciuch

    IFNγ causes mitochondrial dysfunction and oxidative stress in myositis, 2024, Abad et al.

    IFNγ causes mitochondrial dysfunction and oxidative stress in myositis Catalina Abad, Iago Pinal-Fernandez, Clement Guillou, Gwladys Bourdenet, Laurent Drouot, Pascal Cosette, Margherita Giannini, Lea Debrut, Laetitia Jean, Sophie Bernard, Damien Genty, Rachid Zoubairi, Isabelle Remy-Jouet...
    • jnmaciuch
    • Thread
    • ifny interferon gamma mitochondria mitochondrial architecture mitochondrial dysfunction mitochondrial myopathy myositis transcriptomics
    • Replies: 14
    • Forum: Other health news and research
  12. SNT Gatchaman

    Review Mitochondrial innate immune signaling in skeletal muscle adaptation to exercise, 2025, Ma, Hwang et al.

    Mitochondrial innate immune signaling in skeletal muscle adaptation to exercise Jin Ma; Annie Yujin Son; Youlim Son; Ping-yuan Wang; Paul M. Hwang Exercise-induced inflammation is regarded as a response to muscle damage from mechanical stress, but controlled immune signaling can be beneficial...
  13. chillier

    Indistinguishable mitochondrial phenotypes after exposure of healthy myoblasts to myalgic encephalomyelitis or control serum, 2026, Ryback et al

    See post #76 for peer-reviewed version. Indistinguishable mitochondrial phenotypes after exposure of healthy myoblasts to myalgic encephalomyelitis or control serum Audrey A. Ryback, Charles Hillier, Camila M Loureiro, Chris P Ponting, Caroline F Dalton Myalgic Encephalomyelitis (ME)/Chronic...
  14. Dolphin

    Heat vs. Fatigue: Hyperthermia as a Possible Treatment Option for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2025, Hochecker

    https://www.mdpi.com/1422-0067/26/11/5339# Open Access Article Heat vs. Fatigue: Hyperthermia as a Possible Treatment Option for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) by Barbara Hochecker 1,*, Katja Matt 1, Melanie Scherer 1, Alica Meßmer 1, Alexander von Ardenne 2...
    • Dolphin
    • Thread
    • autophagy bip grp78 hsp hyperthermia mitochondria oxygen use seahorse sod2 ulk
    • Replies: 24
    • Forum: ME/CFS research
  15. SNT Gatchaman

    Preprint The Role of SARS-CoV-2 Nucleocapsid Protein Persistence in Inducing Chronic Type I Interferon and Mitochondrial Dysfunction., 2025, Koenig et al.

    The Role of SARS-CoV-2 Nucleocapsid Protein Persistence in Inducing Chronic Type I Interferon and Mitochondrial Dysfunction. Andreas Koenig; Mohammad Quasem; Benjamin Zink; Doniyorbek Abdulla-Zoda; Priyanka Karunanidhi; Karolina Sienko; Christian Geier; Venkatesh Jayaraman; Rabia Malik; Kanza...
    • SNT Gatchaman
    • Thread
    • autoimmunity inteferon mavs mitochondria mitochondrial dysfunction systemic lupus erythematosus viral persistence
    • Replies: 0
    • Forum: Long Covid research
  16. Sly Saint

    Natural polyphenol boosts mitochondrial function and muscle performance during aging

    Natural polyphenol boosts mitochondrial function and muscle performance during aging I recently started taking olive leaf extract for quite different reasons before I found this, so it will be interesting to see if it has any other beneficial effects.
  17. forestglip

    [Transcriptome] in PBMCs of [LC] at a median follow-up of 28 months [...] reveals upregulation of JAK/STAT [...], 2025, Fineschi et al

    Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response Serena Fineschi, Joakim Klar, Juan Ramon Lopez Egido, Jens Schuster, Jonas Bergquist...
    • forestglip
    • Thread
    • annexin atp haemoglobin histone il-9 interferon jak-stat lactate long covid mitochondria mitochondrial dysfunction neutrophils oxidative phosphorylation ubiquitination
    • Replies: 19
    • Forum: Long Covid research
  18. SNT Gatchaman

    Review Regulation of synaptic mitochondria by extracellular vesicles and its implications for neuronal metabolism and synaptic plasticity, 2025,Zeng,Antoniou

    Regulation of synaptic mitochondria by extracellular vesicles and its implications for neuronal metabolism and synaptic plasticity Yuzhou Zeng; Anna Antoniou Mitochondrial metabolism in neurons is necessary for energetically costly processes like synaptic transmission and plasticity. As...
  19. SNT Gatchaman

    Persistent Monocytic Bioenergetic Impairment and Mitochondrial DNA Damage in PASC Patients with Cardiovascular Complications, 2025, Semo+

    Persistent Monocytic Bioenergetic Impairment and Mitochondrial DNA Damage in PASC Patients with Cardiovascular Complications Semo, Dilvin; Shomanova, Zornitsa; Sindermann, Jürgen; Mohr, Michael; Evers, Georg; Motloch, Lukas J.; Reinecke, Holger; Godfrey, Rinesh; Pistulli, Rudin Cardiovascular...
    • SNT Gatchaman
    • Thread
    • caspase caspase-1 glutathione grp78 il-1b immunoparalysis inflammasome mitochondria monocytes mtdna oxidative stress reactive oxygen species seahorse tlr-4 tlr-9
    • Replies: 2
    • Forum: Long Covid research
  20. SNT Gatchaman

    A human brain map of mitochondrial respiratory capacity and diversity, 2025, Mosharov et al.

    A human brain map of mitochondrial respiratory capacity and diversity Mosharov, Eugene V.; Rosenberg, Ayelet M.; Monzel, Anna S.; Osto, Corey A.; Stiles, Linsey; Rosoklija, Gorazd B.; Dwork, Andrew J.; Bindra, Snehal; Junker, Alex; Zhang, Ya; Fujita, Masashi; Mariani, Madeline B.; Bakalian...
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