ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox
Laura F. DiGiovanni; Prabhsimran K. Khroud; Ruth E. Carmichael; Tina A. Schrader; Shivneet K. Gill; Kyla Germain; Robert Y. Jomphe; Christoph Wiesinger; Maxime Boutry; Maki Kamoshita; Daniel Snider; Garret Stubbings...
Abstract
The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in widespread morbidity and mortality, with a significant portion of the affected population experiencing long-term health complications. This review explores the mechanisms of mitochondrial dysfunction in both the acute and...
Endothelial TERT drives microvascular phenotype associated with coronary artery disease
Erin C. Birch; Yoshinori Nishijima; Shelby N. Hader; Andreas M. Beyer
Microvascular endothelial dysfunction is a powerful predictor of future atherosclerotic cardiac events. Our previous studies revealed...
https://www.preprints.org/manuscript/202507.0058/v1
Abstract
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating, multi-system disease characterized by profound fatigue, post-exertional malaise (PEM), and a constellation of immune, neurological, and autonomic symptoms...
Electron-Microscopic Investigation of Muscle Mitochondria in Chronic Fatigue Syndrome
Audrius V. Plioplys; Sigita Plioplys
Abstract
Patients with chronic fatigue syndrome (CFS) suffer from disabling physical and mental fatigue. Abnormalities in mitochondrial function can lead to fatigue and...
Mitochondrial innate immune signaling in skeletal muscle adaptation to exercise
Jin Ma; Annie Yujin Son; Youlim Son; Ping-yuan Wang; Paul M. Hwang
Exercise-induced inflammation is regarded as a response to muscle damage from mechanical stress, but controlled immune signaling can be beneficial...
See post #76 for peer-reviewed version.
Indistinguishable mitochondrial phenotypes after exposure of healthy myoblasts to myalgic encephalomyelitis or control serum
Audrey A. Ryback, Charles Hillier, Camila M Loureiro, Chris P Ponting, Caroline F Dalton
Myalgic Encephalomyelitis (ME)/Chronic...
https://www.mdpi.com/1422-0067/26/11/5339#
Open Access
Article
Heat vs. Fatigue: Hyperthermia as a Possible Treatment Option for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
by
Barbara Hochecker
1,*,
Katja Matt
1,
Melanie Scherer
1,
Alica Meßmer
1,
Alexander von Ardenne
2...
The Role of SARS-CoV-2 Nucleocapsid Protein Persistence in Inducing Chronic Type I Interferon and Mitochondrial Dysfunction.
Andreas Koenig; Mohammad Quasem; Benjamin Zink; Doniyorbek Abdulla-Zoda; Priyanka Karunanidhi; Karolina Sienko; Christian Geier; Venkatesh Jayaraman; Rabia Malik; Kanza...
Natural polyphenol boosts mitochondrial function and muscle performance during aging
I recently started taking olive leaf extract for quite different reasons before I found this, so it will be interesting to see if it has any other beneficial effects.
Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response
Serena Fineschi, Joakim Klar, Juan Ramon Lopez Egido, Jens Schuster, Jonas Bergquist...
Regulation of synaptic mitochondria by extracellular vesicles and its implications for neuronal metabolism and synaptic plasticity
Yuzhou Zeng; Anna Antoniou
Mitochondrial metabolism in neurons is necessary for energetically costly processes like synaptic transmission and plasticity. As...
Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19
Ronaldo Lira-Junior; Anoop Ambikan; Axel Cederholm; Ssefanit Rezene; Flora Mikaeloff; Sara Svensson Akusjarvi; Ahmet Yalcinkaya; Xi Chen; Maike Sperk...
Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Abu Mohammad Syed; Alexander K. Karius; Jin Ma; Ping-yuan Wang; Paul M. Hwang
ME/CFS is a debilitating multisystem disorder of unclear etiology that affects many individuals worldwide. One of its hallmark symptoms...
Rhodoquinone carries electrons in the mammalian electron transport chain
Jonathan Valeros et 31 al.
Ubiquinone (UQ), the only known electron carrier in the mammalian electron transport chain (ETC), preferentially delivers electrons to the terminal electron acceptor oxygen (O2). In hypoxia...
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