mitochondria

A human brain map of mitochondrial respiratory capacity and diversity Mosharov, Eugene V.; Rosenberg, Ayelet M.; Monzel, Anna S.; Osto, Corey A.; Stiles, Linsey; Rosoklija, Gorazd B.; Dwork, Andrew J.; Bindra, Snehal; Junker, Alex; Zhang, Ya; Fujita, Masashi; Mariani, Madeline B.; Bakalian...

Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19 Ronaldo Lira-Junior; Anoop Ambikan; Axel Cederholm; Ssefanit Rezene; Flora Mikaeloff; Sara Svensson Akusjarvi; Ahmet Yalcinkaya; Xi Chen; Maike Sperk...

POLG diseases: Rare genetic conditions that starve cells of energy and afflicted the late Prince of Luxembourg

Hi all! I'm a graduate student living with ME/CFS and currently studying ME/CFS and long COVID. I was recently reviewing literature on mitochondrial dysfunction and stumbled onto something very interesting which potentially explains several semi-consistent findings in the literature...

Highlights • Dengue and Zika viruses alter endoplasmic reticulum-mitochondria contact sites (ERMC) • Mitochondrial respiration is perturbed over the course of the infection • ERMC protein knockdown increases viral replication • ERMC proteins RRBP1 and SYNJ2BP regulate Zika virus-induced cell...

1H and 31P MR Spectroscopy to Assess Muscle Mitochondrial Dysfunction in Long COVID Lucy E. M. Finnigan, Mark Philip Cassar, Mehrsa Jafarpour, Antonella Sultana, Zakariye Ashkir, Karim Azer, Stefan Neubauer, Damian J. Tyler, Betty Raman, Ladislav Valkovič Background Emerging evidence suggests...

Astrocytic mitochondrial transfer to brain endothelial cells and pericytes in vivo increases with aging Gopal V Velmurugan; Hemendra J Vekaria; Samir P Patel; Patrick G Sullivan; W Brad Hubbard Intercellular mitochondrial transfer (IMT) is an intriguing biological phenomenon where mitochondria...

Good day my peeps, I would like to know if anyone has tried Red Light Therapy with a proper device (quality, third party tested etc.). If yes, what was your experience? Thank you... Low-Intensity Light Therapy: Exploring the Role of Redox Mechanisms - PMC

Cellular ATP demand creates metabolically distinct subpopulations of mitochondria Ryu, Keun Woo; Fung, Tak Shun; Baker, Daphne C.; Saoi, Michelle; Park, Jinsung; Febres-Aldana, Christopher A.; Aly, Rania G.; Cui, Ruobing; Sharma, Anurag; Fu, Yi; Jones, Olivia L.; Cai, Xin; Pasolli, H. Amalia...

Novel biomarkers of mitochondrial dysfunction in Long COVID patients Szögi, Titanilla; Borsos, Barbara N.; Masic, Dejana; Radics, Bence; Bella, Zsolt; Bánfi, Andrea; Ördög, Nóra; Zsiros, Csenge; Kiricsi, Ágnes; Pankotai-Bodó, Gabriella; Kovács, Ágnes; Paróczai, Dóra; Botkáné, Andrea Lugosi...

KEY POINTS Question: Determine the short- and long-term physical impairments and skeletal muscle cellular changes in survivors of critical COVID. Findings: Survivors of critical COVID have high prevalence of weakness, fatigue, and reduced functional exercise capacity with muscle tissue...

Editor’s summary Increased plasma creatine is associated with type 2 diabetes, but causation has not been established. Rizo-Roca et al. show that men with type 2 diabetes had increased plasma creatine and decreased muscle phosphocreatine, which was associated with poor glucose handling. In...

https://www.sciencedirect.com/science/article/abs/pii/S0960896624003353 571P Muscular metabolic plasticity in 3D in vitro models against systemic stress factors in ME/CFS and long COVID-19 Author links 1 Institute For Bioengineering Of Catalonia BIST, Barcelona, Spain 2 ICREA Institució...

https://www.researchsquare.com/article/rs-4654793/v1 Mitochondrial function in patients affected with fibromyalgia syndrome is impaired and correlates with disease severity Chiara Macchi1 Andrea Giachi1 Isabella Fichtner1 Silvia Pedretti1 Piercarlo Sarzi Puttini2 Nico Mitro1 Alberto...

Numerous people are being diagnosed as having CFS and fibro after apparent remission of sarcoidosis. Numerous questions arise 1) What does the diagnoser know about CFS or fibro? 2) What does the diagnoser know about work on post sarcoid fatigue vs sarcoid e.g. persistent shift to TH1 in post...

ABSTRACT Dengue virus (DENV) infection is known to affect host cell metabolism, but the molecular players involved are still poorly known. Using a proteomics approach, we identified six DENV proteins associated with mitochondria isolated from infected hepatocytes, and most of the peptides...

Abstract OBJECTIVES: The pathogenesis of fibromyalgia (FM), characterised by chronic widespread pain and fatigue, remains notoriously elusive, hampering attempts to develop disease modifying treatments. Mitochondria are the headquarters of cellular energy metabolism, and their malfunction has...

Link to article By David Cox

Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST Hans-Georg Sprenger; Melanie J. Mittenbühler; Yizhi Sun; Jonathan G. Van Vranken; Sebastian Schindler; Abhilash Jayaraj; Sumeet A. Khetarpal; Ariana Vargas-Castillo; Anna M. Puszynska; Jessica...

miR-29a-3p, a new myokine orchestrating resistance exercise via coordinated metabolic responses Paola Pinto-Hernandez; Manuel Fernandez-Sanjurjo; Daan Paget; Xurde M Caravia; David Roiz-Valle; Juan Castilla-Silgado; Sergio Diez-Robles; Almudena Coto-Vilcapoma; Pau Gama; Pablo M Garcia-Roves...