mitochondria

Muscle Abnormalities in Nonhospitalised Patients With Post–COVID-19 Condition BACKGROUND Post-COVID condition (PCC) affects ~10% of SARS-CoV-2–infected individuals and manifests as persistent symptoms such as fatigue, exercise intolerance and muscle weakness. This study aimed to assess the...

Circulating Levels of SMPDL3B Define Metabolic Endophenotypes and Subclinical Kidney Alterations in Myalgic Encephalomyelitis Myalgic Encephalomyelitis (ME) is a complex, multisystem disorder with poorly understood pathophysiological mechanisms. SMPDL3B, a membrane-associated protein expressed...

The power and potential of mitochondria transfer Borcherding N, Brestoff JR. Preface Mitochondria are believed to have originated through an ancient endosymbiotic process in which proteobacteria were captured and co-opted for energy production and cellular metabolism. Mitochondria segregate...

https://www.preprints.org/manuscript/202509.2242/v1 Authors: Klaus Wirth, Jürgen M. Steinacker Abstract Severely ill ME/CFS patients are bedridden and suffer from hypersensitivities against light and noise, severe orthostatic intolerance reducing cerebral blood flow, and skeletal muscle...

Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability Kim, Haeun; Tian, Ya-Min; Ratcliffe, Peter J; Keeley, Thomas P Selected proteins containing an N-terminal cysteine (Nt-Cys) are subjected to rapid, O2-dependent proteolysis via the Cys/Arg-branch of the...

Mitochondrial activity tunes nociceptor resilience to excitotoxicity Lin Yuan; Navdeep S Chandel; David Julius The capsaicin receptor, TRPV1, mediates the detection of noxious chemical and thermal stimuli by nociceptors, primary sensory neurons of the pain pathway. Overactivation of TRPV1 leads...

Split from United Kingdom: ME Research UK (MERUK) News From MERUK at the link above:

Interferon-Linked Lipid and Bile Acid Imbalance Uncovered in Ankylosing Spondylitis in a Sibling-Controlled Multi-Omics Study Ankylosing spondylitis (AS) displays wide inter-patient variability that is not accounted for by HLA-B27 alone, suggesting that additional immune and metabolic...

Mitochondrial function is impaired in long COVID patients BACKGROUND The Long COVID syndrome is a major global health problem, affecting approximately 10–20% of individuals infected with SARS-CoV-2 virus with many remaining symptomatic beyond one year. Fatigue, reduced exercise tolerance and...

A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease Mitophagy is a fundamental quality control mechanism of mitochondria. Its regulatory mechanisms and pathological implications remain poorly understood. Here, via...

DecodeME candidate ME/CFS gene ******************** FBXL4 (Tier 2) • Protein: F-box/LRR-repeat protein 4. UniProt. GeneCards. • Molecular function: Component of the mitochondria-localised SCF-FBXL4 ubiquitin E3 ligase complex. This complex restricts mitophagy by controlling the degradation...

Preliminary abstract, see post #13 for final paper. ----------------- https://www.sciencedirect.com/science/article/abs/pii/S0960896624003353 571P Muscular metabolic plasticity in 3D in vitro models against systemic stress factors in ME/CFS and long COVID-19 Author links 1 Institute For...

The Roles of Lactate and Lactylation in Diseases Related to Mitochondrial Dysfunction Ma, Fei; Yu, Wei Glycolysis and oxidative phosphorylation are the main pathways of cellular energy production. Glucose is metabolized via glycolysis to generate pyruvate, which, under anaerobic conditions, is...

https://interestingengineering.com/health/brain-healing-nanoflowers-treatment :emoji_rosette:

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox Laura F. DiGiovanni; Prabhsimran K. Khroud; Ruth E. Carmichael; Tina A. Schrader; Shivneet K. Gill; Kyla Germain; Robert Y. Jomphe; Christoph Wiesinger; Maxime Boutry; Maki Kamoshita; Daniel Snider; Garret Stubbings...

Abstract The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in widespread morbidity and mortality, with a significant portion of the affected population experiencing long-term health complications. This review explores the mechanisms of mitochondrial dysfunction in both the acute and...

Endothelial TERT drives microvascular phenotype associated with coronary artery disease Erin C. Birch; Yoshinori Nishijima; Shelby N. Hader; Andreas M. Beyer Microvascular endothelial dysfunction is a powerful predictor of future atherosclerotic cardiac events. Our previous studies revealed...

https://www.preprints.org/manuscript/202507.0058/v1 Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating, multi-system disease characterized by profound fatigue, post-exertional malaise (PEM), and a constellation of immune, neurological, and autonomic symptoms...

Electron-Microscopic Investigation of Muscle Mitochondria in Chronic Fatigue Syndrome Audrius V. Plioplys; Sigita Plioplys Abstract Patients with chronic fatigue syndrome (CFS) suffer from disabling physical and mental fatigue. Abnormalities in mitochondrial function can lead to fatigue and...

IFNγ causes mitochondrial dysfunction and oxidative stress in myositis Catalina Abad, Iago Pinal-Fernandez, Clement Guillou, Gwladys Bourdenet, Laurent Drouot, Pascal Cosette, Margherita Giannini, Lea Debrut, Laetitia Jean, Sophie Bernard, Damien Genty, Rachid Zoubairi, Isabelle Remy-Jouet...