mitochondrial dysfunction

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact Willian A. da Silveira; Hossein Fazelinia; Sara Brin Rosenthal; Evagelia C. Laiakis; Man S. Kim; Cem Meydan; Yared Kidane; Komal S. Rathi; Scott M. Smith; Benjamin Stear; Yue Ying...

paywalled https://www.science.org/doi/10.1126/science.abj5559 Abstract Cells respond to mitochondrial poisons with rapid activation of the adenosine monophosphate–activated protein kinase (AMPK), causing acute metabolic changes through phosphorylation and prolonged adaptation of metabolism...

Preprint. Paper now published, see this post Abstract A blood-based diagnostic test for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and multiple sclerosis (MS) would be of great value in both conditions, facilitating more accurate and earlier diagnosis, helping with current...

via Dr. Marc-Alexander Fluks Source: Cornell University Date: May 2022 URL: https://ecommons.cornell.edu/handle/1813/111644 https://ecommons.cornell.edu/bitstream/handle/1813/111644/Pandey_cornell_0058O_11430.pdf Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and mitochondria: A...

Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology Eva K Hejbøl, Thomas Harbo, Jane Agergaard, Line B Madsen, Thomas H Pedersen, Lars J Østergaard, Henning Andersen, Henrik D Schrøder, Hatice Tankisi Background: Among post-COVID-19...

To the Editor: After acute infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many individuals experience a range of symptoms including dyspnea, exercise intolerance, and chest pain commonly referred to as “post–COVID-19 syndrome” or as post-acute sequelae of...

Full title: A time-dependently regulated gene network reveals that Aspergillus protease affects mitochondrial metabolism and airway epithelial cell barrier function via mitochondrial oxidants Highlights • Fungal protease-induced mitochondrial ROS production in bronchial epithelial cells. •...

Abstract The mitochondrial membrane potential (ΔΨm) is a parameter often used to determine mitochondrial function; therefore, it can be used to determine the integrity and functionality of cells. A decrement of ΔΨm is implicated in several inflammatory-related pathologies, such phenomena can be...

Full title: Does Dietary Coenzyme Q10 plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome? Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a...

"Reneo is a clinical stage pharmaceutical company focused on the development and commercialization of therapies for patients with rare genetic mitochondrial diseases, which are often associated with the inability of mitochondria to produce adenosine triphosphate (ATP). Reneo is developing REN001...

I put this post here as I couldn't see a section for Primary Mitochondrial Disease in Missed/Alternative Diagnosis section... Given the advice that if 3 or more systems are involved that it could possibly be a genetic/primary mitochondrial disease it would seem that anyone that meets ICC/CCC...

not listened to it so no idea of content. https://player.fm/series/one-thing-with-dr-adam-rinde/mitochondrial-dysfunction-and-autism-with-dr-richard-g-boles

Full title: Co-Exposure of Cardiomyocytes to IFN-γ and TNF-α Induces Mitochondrial Dysfunction and Nitro-Oxidative Stress: Implications for the Pathogenesis of Chronic Chagas Disease Cardiomyopathy Infection by the protozoan Trypanosoma cruzi causes Chagas disease cardiomyopathy (CCC) and can...

Posts copied from The micro-clot finding in Long Covid — implications for the possible aetiology of ME/CFS...

Posts moved from this thread: Trial of Long Covid treatment - AXA1125 from Axcella Therapeutics, 2021 ________________ Use of whole genome sequencing to determine genetic basis of suspected mitochondrial disorders: cohort study Abstract Objective To determine whether whole genome sequencing...

In worms. Abstract Huntington’s disease (HD) is an adult-onset neurodegenerative disease caused by a trinucleotide CAG repeat expansion in the HTT gene. While the pathogenesis of HD is incompletely understood, mitochondrial dysfunction is thought to be a key contributor. In this work, we...

Highlights • Mitochondrial respiration decreases with age in PBMCs from healthy individuals. • PBMC mtDNA copy number increases in patients with mitochondrial disease. • Normalizing respiration by mtDNA reveals mitochondrial deficits in patients’ PBMCs. • Platelet basal and ATP-dependent...

Abstract Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontitis, has been shown to accelerate the progression of atherosclerosis (AS). However, the definite mechanisms remain elusive. Emerging evidence supports an association between mitochondrial dysfunction and AS. In our...

biomolecules: Bioenergetic and Proteomic Profiling of Immune Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients: An Exploratory Study Fernandes-Guerra et al Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a heterogeneous, debilitating, and complex...

Abstract. Estrogen-related receptor gamma (Esrrg) is a murine lupus susceptibility gene associated with T cell activation. Here, we report that Esrrg controls regulatory T cells (Treg) through mitochondria homeostasis. Esrrg deficiency impaired the maintenance and function of Treg cells...