muscle

Pilot Study of Peripheral Muscle Function in Primary Biliary Cirrhosis: Potential Implications for Fatigue Pathogenesis BACKGROUND & AIMS Primary biliary cirrhosis (PBC) is characterized in 95% of patients by autoantibody responses directed against the mitochondrial antigen pyruvate...

Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome OBJECTIVES To examine muscle acid handling following exercise in chronic fatigue syndrome (CFS⁄ME) and the relationship with autonomic dysfunction. DESIGN...

Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis BACKGROUND & AIMS Upon exercise, primary biliary cirrhosis (PBC) is associated with significant acidosis in peripheral muscle with recovery rate from acidosis strongly...

Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: a case–control study BACKGROUND Chronic fatigue syndrome (CFS) patients frequently describe difficulties with repeat exercise. Here, we explore muscle bioenergetic function in response to three bouts of...

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender Excessive exercise impairs cognitive function, but the underlying mechanism remains unclear. Here, we show that excessive vigorous exercise-induced lactate accumulation stimulates muscles to...

Magnetic Resonance Quantification of Muscle Phosphocreatine Resynthesis Kinetics During Exercise Recovery: An In Vivo Measure of Mitochondrial Function in Humans Quantifying muscle phosphocreatine (PCr) resynthesis kinetics during recovery from exercise can be employed as a sensitive and...

Highlights • Plasma profiling of 7,288 proteins during post-exertional malaise in ME/CFS. • ME/CFS participants show sustained immune, metabolic, and neuromuscular dysregulation during post-exercise recovery. • Exertion disrupts T and B cell signaling, IL-17 pathways, and mitochondrial...

Muscle strength, muscle endurance, voluntary activation, and perception of effort in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): an overview Nuzzo, James L.; Taylor, Janet L.; Latella, Christopher Abstract Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)...

Muscle and cerebral oxygenation during exercise in fibromyalgia: a near-infrared spectroscopy study Taneli Lehto, Teemu Zetterman, Dominique Gagnon, Ritva Markkula, Jari Arokoski, Eija Kalso & Juha E. Peltonen [Line breaks added] Purpose We studied muscle and brain oxygenation during...

[The full poster may or may not be longer] https://www.sciencedirect.com/science/article/abs/pii/S0960896625002196 Neuromuscular Disorders Volume 53, Supplement, September 2025, 105492 29PMyological evaluation of patients with post-acute COVID-19 syndrome F. Authier 1 2, M. Aoun Sebaiti 1, S...

Muscle Abnormalities in Nonhospitalised Patients With Post–COVID-19 Condition BACKGROUND Post-COVID condition (PCC) affects ~10% of SARS-CoV-2–infected individuals and manifests as persistent symptoms such as fatigue, exercise intolerance and muscle weakness. This study aimed to assess the...

Acid-sensing ion channel 3 in macrophages, but not sensory neurons, mediates development of activity-induced muscle pain Activity-induced pain is a significant symptom for people with chronic pain and reduces participation in daily activities and effective exercise programs. We previously...

Variation in Repeated Handgrip Strength Testing Indicates Submaximal Force Production in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Stoyan Popkirov Background Changes in handgrip strength have recently been adapted as clinical biomarkers for myalgic...

Leandro Ferreira, Isabella Da Silva Almeida, Rochelle Rocha Costa, Gabrielle Vieira Roriz, Jeam Marcel Geremia, Joao Luiz Quaglioti Durigan, Rita de Cássia Marqueti Introduction: There are limited studies on the long-term effects of COVID-19 on skeletal muscle morphology and architecture...

Metabolic adaptation and fragility in healthy 3-D in vitro skeletal muscle tissues exposed to Chronic Fatigue Syndrome and Long COVID-19 sera. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID-19 (LC-19) are complex conditions with no diagnostic markers or consensus on...

Link to the published paper here ***************************************** This is a preliminary presentation: https://academic.oup.com/ijnp/article/28/Supplement_1/i60/8009437 https://academic.oup.com/ijnp/article-pdf/28/Supplement_1/i60/61854477/pyae059.104.pdf Journal Article MECHANISMS...

[68Ga]FAPI PET/CT reveals increased pulmonary fibroblast activation protein expression in long COVID patients after ICU discharge B. van Leer, M. Londema, Ö. Kasalak, J. H. van Snick, M. L. Duiverman, J. C. Kuijvenhoven, M. D. de Kruif, D. E. Oprea-Lager, K. Pabst, M. E. Hellemons, H. H...

Abstract: Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where symptoms worsen with cognitive or physical exertion. PEM often results in avoidance...

Abstract Mitochondria are essential in supplying energy to skeletal muscle. Near-infrared spectroscopy (NIRS) was developed to noninvasively assess mitochondrial capacity (mV̇O2max) as a rate constant of metabolic recovery after exercise. Purpose This study measured the time course mV̇O2max...

ABSTRACT Background Recent studies provide strong evidence for a key role of skeletal muscle pathophysiology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In a 2021 review article on the pathophysiology of ME/CFS, we postulated that hypoperfusion and ischemia can result in...