muscle

Macrophage SREBP1 regulates skeletal muscle regeneration Oishi, Yumiko; Koike, Hiroyuki; Kumagami, Naoki; Nakagawa, Yoshimi; Araki, Masaya; Taketomi, Yoshitaka; Miki, Yoshimi; Matsuda, Shigeru; Matsuzaka, Takashi; Ozawa, Hitoshi; Shimano, Hitoshi; Murakami, Makoto; Manabe, Ichiro Macrophages...

Abstract The purpose of this study was to establish if muscle aerobic metabolism is abnormal in chronic fatigue syndrome (CFS). Myoblast cultures from muscle biopsies of 16 patients with CFS and 10 healthy controls were established. Micromethods were used to determine the lactate/pyruvate (L/P)...

Summary We have examined the muscle biopsies of 50 patients who had postviral fatigue syndrome (PFS) for from 1 to 17 years. We found mild to severe atrophy of type II fibres in 39 biopsies, with a mild to moderate excess of lipid. On ultrastructural examination, 35 of these specimens showed...

Mitochondrial morphology and function in mitochondrial disease Julie Faitg; Tracey Davey; Ross Laws; Conor Lawless; Helen Tuppen; Eric Fitton; Doug Elizabeth Turnbull; Amy Elizabeth Vincent Mitochondria play a crucial role in maintaining cellular health. It is interesting that the shape of...

Differential Cardiopulmonary Hemodynamic Phenotypes in PASC Related Exercise Intolerance https://openres.ersjournals.com/content/early/2023/12/07/23120541.00714-2023 Background Post-acute sequelae of COVID-19 (PASC) affects a significant portion of patients who have previously contracted...

Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity Vermeulen, Ruud CW; Kurk, Ruud M; Visser, Frans C; Sluiter, Wim; Scholte, Hans R Background The aim of this study was to investigate...

Maximal oxidative capacity during exercise is associated with muscle power output in patients with long coronavirus disease 2019 COVID-19 syndrome. A moderation analysis Robinson Ramírez-Vélez; Sergio Oscoz-Ochandorena; Yesenia García-Alonso; Nora García-Alonso; Gaizka Legarra-Gorgoñon; Julio...

Introduction Monitoring muscle metabolic activity via blood lactate is a useful tool for understanding the physiological response to a given exercise intensity. Recent indications suggest that skeletal muscle oxygen saturation (SmO2), an index of the balance between local O2 supply and demand...

Link to post on published version Internal tremors and vibrations in long COVID: a cross-sectional study Tianna Zhou; Mitsuaki Sawano; Adith S. Arun; César Caraballo; Teresa Michelsen; Lindsay McAlpine; Bornali Bhattacharjee; Yuan Lu; Rohan Khera; Chenxi Huang; Frederick Warner; Akiko Iwasaki...

"We found that metformin-treated individuals had less type-I myofiber atrophy during disuse, reduced pro-inflammatory transcriptional profiles, and lower muscle collagen deposition during recovery. Collagen content and myofiber size corresponded to reduced whole muscle cellular senescence and...

Structural and functional impairments of skeletal muscle in patients with post-acute sequelae of SARS-CoV-2 infection Marta Colosio ; Lorenza Brocca ; Marco Gatti ; Marianna Neri ; Emanuela Crea ; Francesca Cadile ; Monica Canepari ; Maria Antonietta Pellegrino ; Biagio Polla ; Simone...

Muscle Abnormalities Contribute to Post-Exertional Malaise in Long COVID A poster presentation of the very soon to be published work by Rob Wüsts team has been uploaded to Twitter. Paper now published, see post #8

Abstract Healthy skeletal muscle can regenerate after ischaemic, mechanical, or toxin-induced injury, but ageing impairs that regeneration potential. This has been largely attributed to dysfunctional satellite cells and reduced myogenic capacity. Understanding which signalling pathways are...

Highlights • Does force failure result from sarcolemma fatigue in Myalgic Encephalomyelitis patients? • Two groups of Myalgic Encephalomyelitis patients with or not M wave alterations were compared. • Maximal handgrip strength and M wave in forearm muscle were simultaneously measured. •...

A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy Nneka Southwell; Guido Primiano; Viraj Nadkarni; Nabeel Attarwala; Emelie Beattie; Dawson Miller; Sumaitaah Alam; Irene Liparulo; Yevgeniya I Shurubor; Maria Lucia Valentino; Valerio Carelli; Serenella...

Myopathy as a cause of Long COVID fatigue: Evidence from quantitative and single fiber EMG and muscle histopathology Highlights Myopathic changes in qEMG and/or increased jitter in sfEMG were seen in 63% of 84 patients with Long COVID neuromuscularsymptoms. Low quality of life score correlated...

I randomly came across an article on McArdle disease (a genetic disorder that mainly affects skeletal muscles), and found the description of exertion intolerance both interesting and relatable. Does anyone here know if there has been any scientific attempts to compare the exertion intolerance...

Loss of Skeletal Muscle Pyruvate Dehydrogenase Induces Lactic Acidosis and Adaptive Anaplerotic Compensation via Pyruvate-Alanine Cycling and Glutaminolysis Keshav Gopal; Abdualrahman Mohammed Abdualkader; Xiaobei Li; Amanda A. Greenwell; Qutuba G. Karwi; Christina Saed; Golam M. Uddin; Ahmed M...

Highlights Muscle injury induces local accumulation of RORγ+ Treg cells emanating from the gut The microbiota regulates muscle repair via RORγ+ Treg cells Muscle RORγ+ Treg cells shield differentiating muscle stem cells from IL-17A RORγ+ Treg cell emissaries play a general role in the...

Abstract During maximal exercise healthy humans increase their oxygen uptake (V̇O2) 10 to 20-fold that measured at rest to as much as 6 L/min. At the molecular level the numbers are staggering: Each minute the exercising O2 transport system - lungs, cardiovascular and active muscles – must...