muscle

Abstract Healthy skeletal muscle can regenerate after ischaemic, mechanical, or toxin-induced injury, but ageing impairs that regeneration potential. This has been largely attributed to dysfunctional satellite cells and reduced myogenic capacity. Understanding which signalling pathways are...

Highlights • Does force failure result from sarcolemma fatigue in Myalgic Encephalomyelitis patients? • Two groups of Myalgic Encephalomyelitis patients with or not M wave alterations were compared. • Maximal handgrip strength and M wave in forearm muscle were simultaneously measured. •...

A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy Nneka Southwell; Guido Primiano; Viraj Nadkarni; Nabeel Attarwala; Emelie Beattie; Dawson Miller; Sumaitaah Alam; Irene Liparulo; Yevgeniya I Shurubor; Maria Lucia Valentino; Valerio Carelli; Serenella...

Myopathy as a cause of Long COVID fatigue: Evidence from quantitative and single fiber EMG and muscle histopathology Highlights Myopathic changes in qEMG and/or increased jitter in sfEMG were seen in 63% of 84 patients with Long COVID neuromuscularsymptoms. Low quality of life score correlated...

I randomly came across an article on McArdle disease (a genetic disorder that mainly affects skeletal muscles), and found the description of exertion intolerance both interesting and relatable. Does anyone here know if there has been any scientific attempts to compare the exertion intolerance...

Loss of Skeletal Muscle Pyruvate Dehydrogenase Induces Lactic Acidosis and Adaptive Anaplerotic Compensation via Pyruvate-Alanine Cycling and Glutaminolysis Keshav Gopal; Abdualrahman Mohammed Abdualkader; Xiaobei Li; Amanda A. Greenwell; Qutuba G. Karwi; Christina Saed; Golam M. Uddin; Ahmed M...

Highlights Muscle injury induces local accumulation of RORγ+ Treg cells emanating from the gut The microbiota regulates muscle repair via RORγ+ Treg cells Muscle RORγ+ Treg cells shield differentiating muscle stem cells from IL-17A RORγ+ Treg cell emissaries play a general role in the...

Abstract During maximal exercise healthy humans increase their oxygen uptake (V̇O2) 10 to 20-fold that measured at rest to as much as 6 L/min. At the molecular level the numbers are staggering: Each minute the exercising O2 transport system - lungs, cardiovascular and active muscles – must...

Serum GDF-15 Levels Accurately Differentiate Patients with Primary Mitochondrial Myopathy, Manifesting with Exercise Intolerance and Fatigue, from Patients with Chronic Fatigue Syndrome Authors from the Neuromuscular Disorders Unit of the Hospital Universitario 12 de Octubre in Madrid (national...

Precision MRI phenotyping of muscle volume and quality at a population scale Marjola Thanaj, Nicolas Basty, Brandon Whitcher, Elena P Sorokin, Yi Liu, Ramprakash Srinivasan, Madeleine Cule, Elizabeth Louise Thomas, Jimmy David Bell Background: Magnetic resonance imaging (MRI) enables direct...

Now published - see post Preprint Post-COVID syndrome is associated with capillary alterations, macrophage infiltration and distinct transcriptomic signatures in skeletal muscles Tom Aschman, Emanuel Wyler, Oliver Baum, Andreas Hentschel, Franziska Legler, Corinna Preusse, Lil Meyer-Arndt...

Abstract Background Muscle fatigue and pain are key symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Although the pathophysiology is not yet fully understood, there is ample evidence for hypoperfusion which may result in electrolyte imbalance and sodium overload in...

Abstract Background Patients with long-COVID often complain of continuous fatigue, myalgia, sleep problems, cognitive dysfunction, and post-exertional malaise. No data are available on EMG recording of evoked myopotentials (M-waves) or exercise-induced alterations in long-COVID patients...

Pain is not one of my usual ME/CFS symptoms. When I overexert myself physically and subsequently have post-exertional malaise, my muscles (especially those which I used the most) feel leaden, sore, but not stiff, and they burn. I can relate to the often used description of feeling “poisoned”...

In this article we review complications to the peripheral nervous system that occur as a consequence of viral infections, with a special focus on complications of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We discuss neuromuscular complications in three broad categories; the...

Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology Eva K Hejbøl, Thomas Harbo, Jane Agergaard, Line B Madsen, Thomas H Pedersen, Lars J Østergaard, Henning Andersen, Henrik D Schrøder, Hatice Tankisi Background: Among post-COVID-19...

Apologises if this has been posted - I searched and could not find it. Intramuscular Pressure is Almost Three Times Higher in Fibromyalgia Patients: A Possible Mechanism for Understanding the Muscle Pain and Tenderness https://www.jrheum.org/content/early/2020/09/10/jrheum.191068 Robert S...

Note, this is a study from 1992 is posted for potential future reference. Background Previous study of patients with chronic fatigue syndrome (CFS) has demonstrated a markedly reduced dynamic exercise capacity, not limited by cardiac performance and in the absence of clinical neuromuscular...

Note that this is a study from 1998 and is posted for potential future reference. Abstract It has been shown previously that some patients with chronic fatigue syndrome show an abnormal increase in plasma lactate following a short period of moderate exercise, in the sub-anaerobic threshold...

I came across this paper while looking at a Peter Behan paper from 1985. This paper is from his colleagues using Behan's patients. Abstract Single fibre electromyography (SFEMG) was studied in 40 patients with the post-viral fatigue syndrome. These patients were also assessed clinically...