muscle

Skeletal muscle vasomotor function, ergonomics, histopathology, and gene expression in Veterans with Gulf War Illness Kinlay, Scott; Temiyasathit, Sara; Ly, Samantha; Quinn, Margot; Bundy, Mariah; Chin, Melissa; Do, Jacquelyn-My; Johnson, Shannon; Allsup, Kelly; Burch, Micah L.; Beerens, Manu...

Now published, see post #8. Preprint: Muscle Symptoms Define a Stable Physiological Dysregulation Cluster in ME/CFS: Sex- and Menopause-Related Differences in Symptom Expression Habermann-Horstmeier, Lotte; Horstmeier, Lukas Maximilian Background Muscle-related symptoms are among the most...

Persistent neuromuscular dysfunction in long COVID: A quantitative and single fiber EMG follow-up study OBJECTIVE Persistent symptoms after SARS CoV-2 infection, often designated as "long COVID”, continue to be an ongoing health issue. Previously, we reported electromyography (EMG) and single...

Now published, see post #5. iPSC-Derived Myogenic Progenitor Cells from People with ME/CFS Reveal Altered Genes and Pathways with Drug Repurposing Potential Nguyen, Dao Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disorder...

Patterns of Muscle Health in Single- and Multi-Site Chronic Pain: A UK Biobank Normative Modeling Study BACKGROUND Chronic pain is associated with impaired muscle health, but whether these changes reflect site-specific factors, broader systemic factors, or both remains unclear. The purpose of...

Muscle fatigue in patients with severe long COVID: A 2‐year follow‐up study Background Fatigue is recognized as one of the most persistent and debilitating symptoms of long COVID, affecting both functionality and quality of life. However, its long‐term effects, especially beyond the first...

https://www.actionforme.org.uk/register-for-the-prime-international-symposium/ Register for the PRIME International Symposium! 11 June 2026 Researchers, clinicians, industry representatives, charities and people with lived experience of ME/CFS will come together this September for the PRIME...

B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism B cells are an essential component of humoral immunity, and B cell depletion therapies have clinically succeeded in eliminating cancerous B cells and treating autoimmune diseases. Here, we report an...

NEW & NOTEWORHTY We found that the muscle oxygen consumption rate 15 min after cycling exercise remained three- to fourfold higher than at rest. Higher-intensity exercise resulted in higher postexercise muscle oxygen consumption despite having the same total work during exercise. The...

Pilot Study of Peripheral Muscle Function in Primary Biliary Cirrhosis: Potential Implications for Fatigue Pathogenesis BACKGROUND & AIMS Primary biliary cirrhosis (PBC) is characterized in 95% of patients by autoantibody responses directed against the mitochondrial antigen pyruvate...

Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome OBJECTIVES To examine muscle acid handling following exercise in chronic fatigue syndrome (CFS⁄ME) and the relationship with autonomic dysfunction. DESIGN...

Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis BACKGROUND & AIMS Upon exercise, primary biliary cirrhosis (PBC) is associated with significant acidosis in peripheral muscle with recovery rate from acidosis strongly...

Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: a case–control study BACKGROUND Chronic fatigue syndrome (CFS) patients frequently describe difficulties with repeat exercise. Here, we explore muscle bioenergetic function in response to three bouts of...

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender Excessive exercise impairs cognitive function, but the underlying mechanism remains unclear. Here, we show that excessive vigorous exercise-induced lactate accumulation stimulates muscles to...

Magnetic Resonance Quantification of Muscle Phosphocreatine Resynthesis Kinetics During Exercise Recovery: An In Vivo Measure of Mitochondrial Function in Humans Quantifying muscle phosphocreatine (PCr) resynthesis kinetics during recovery from exercise can be employed as a sensitive and...

Highlights • Plasma profiling of 7,288 proteins during post-exertional malaise in ME/CFS. • ME/CFS participants show sustained immune, metabolic, and neuromuscular dysregulation during post-exercise recovery. • Exertion disrupts T and B cell signaling, IL-17 pathways, and mitochondrial...

Muscle strength, muscle endurance, voluntary activation, and perception of effort in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): an overview Nuzzo, James L.; Taylor, Janet L.; Latella, Christopher Abstract Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)...

Muscle and cerebral oxygenation during exercise in fibromyalgia: a near-infrared spectroscopy study Taneli Lehto, Teemu Zetterman, Dominique Gagnon, Ritva Markkula, Jari Arokoski, Eija Kalso & Juha E. Peltonen [Line breaks added] Purpose We studied muscle and brain oxygenation during...

[The full poster may or may not be longer] https://www.sciencedirect.com/science/article/abs/pii/S0960896625002196 Neuromuscular Disorders Volume 53, Supplement, September 2025, 105492 29PMyological evaluation of patients with post-acute COVID-19 syndrome F. Authier 1 2, M. Aoun Sebaiti 1, S...

Muscle Abnormalities in Nonhospitalised Patients With Post–COVID-19 Condition BACKGROUND Post-COVID condition (PCC) affects ~10% of SARS-CoV-2–infected individuals and manifests as persistent symptoms such as fatigue, exercise intolerance and muscle weakness. This study aimed to assess the...