netrin

Dorsal horn DCC amplification loop induced by endplate osteoclasts generates chronic nociplastic low back pain in male mice Spine degeneration is associated with low back pain (LBP), a major cause of disability and functional decline. However, effective therapies for non-specific LBP remain...

Macrophage-derived netrin-1 contributes to endometriosis-associated pain BACKGROUND Endometriosis-associated pain can be considered a type of neuropathic pain. Netrin-1 is an axon guidance cue that regulates axonal attraction or rejection in neural injury and regeneration. However, whether...

The 15th most significant locus in DecodeME is overlapping the gene DCC. The lead variant at this locus is 18:53232948:C:T (rs72923287) with a p-value of 2.48x10-7. GeneCards summary for DCC: Full gene name: DCC Netrin 1 Receptor "DCC" stands for "Deleted In Colorectal Carcinoma" The...

Now published, see post #74. Identification of Novel Reproducible Combinatorial Genetic Risk Factors for Myalgic Encephalomyelitis in the DecodeME Patient Cohort and Commonalities with Long COVID BACKGROUND Myalgic encephalomyelitis (also known as ME/CFS or simply ME) has severely impacted...

Abstract: Background/Objectives: The aetiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a chronic and severe debilitating disease with a complex phenotype, remains elusive. Associations with infectious diseases and autoimmune and neuropsychiatric disorders have been...