neurological symptoms

Revisiting What HIV in the Brain Can Teach Us About SARS-CoV-2 Neurological Complications Taher, Layan; Arellano, Jekzaly; Al-Harthi, Lena Abstract In 2021, a Perspective article suggested that principles of HIV neuropathogenesis could provide a conceptual framework for understanding the...

Long-term cognitive outcomes after mild COVID-19, critical COVID-19, and non-COVID critical illness: a prospective cohort comparison Abstract Long-term cognitive impairment is a recognized sequela of the post-COVID-19 condition (PCC). While it is unclear how acute COVID-19 severity...

Specialist care at a distance: Patient-reported experience with telemedicine video consultations for neurological symptoms associated with post-COVID-19 condition or in temporal association with COVID-19 vaccination in a single-center retrospective cross-sectional study Abstract Objectives To...

Longitudinal trajectories of neurologic symptoms and cognitive associations at 36-months post-hospitalization for COVID-19 Abstract Background: A substantial proportion of individuals hospitalized for COVID 19 experience persistent neurological and psychiatric symptoms. The long-term...

Persistent neurological and behavioral alterations after SARS-CoV-2 infection in an optimized K18-hACE2 mouse model Abstract Introduction: Persistent neurological symptoms are among the most prevalent and debilitating manifestations of post-COVID-19 Condition (PCC), affecting millions of...

Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I) Brief Summary Background: SARS-CoV-2 is the virus that causes COVID-19.Some people who recover from an acute COVID-19 infection may continue to have symptoms that persist for...

Persistent neurological sequelae in children and adolescents after SARS-CoV-2: a scoping review OBJECTIVES For the past five years, COVID-19 has not only been a priority for health planning but also a hotspot for clinical research. Yet, the weight of the worldwide COVID-19 pandemic arises from...

Exploring Alice in Wonderland syndrome in adults with persistent headache after COVID-19: a cross-sectional study in Latin America BACKGROUND Alice in Wonderland syndrome (AIWS) is a neuropsychiatric disorder characterized by sensory perception distortions, including altered body image...

Long-term neurological and cognitive impact of COVID-19: a systematic review and meta-analysis in over 4 million patients Toka Elboraay, Mahmoud A. Ebada, Maged Elsayed, Heba Ahmed Aboeldahab, Hazem Mohamed Salamah, Omar Rageh, Mohamed Elmallahy, Hadeer Elsaeed AboElfarh, Lena Said Mansour...

Abstract Objective Although SARS-CoV-2 primarily targets the respiratory system, there is evidence that it can also infect the central nervous system, especially in children, leading to neurological symptoms and long-term consequences. It is imperative to summarize the possible mechanisms, main...

Analysis of risk factors for long COVID after mild COVID-19 during the Omicron wave in Japan Hotaka Namie, Takahiro Takazono, Rina Kawasaki, Hiroshi Yano, Yuya Ito, Nana Nakada, Tatsuro Hirayama, Masataka Yoshida, Kazuaki Takeda, Shotaro Ide, Shinnosuke Takemoto, Naoki Iwanaga, Masato Tashiro...

Current update on the neurological manifestations of long COVID: more questions than answers Maria-Ioanna Stefanou; Evangelos Panagiotopoulos; Lina Palaiodimou; Eleni Bakola; Nikolaos Smyrnis; Marianna Papadopoulou; Christos Moschovos; George P. Paraskevas; Emmanouil Rizos; Eleni Boutati; Elias...

Vaccination prior to SARS-CoV-2 infection does not affect the neurologic manifestations of long COVID Mukherjee, Shreya; Singer, Tracey; Venkatesh, Aditi; Choudhury, Natasha A; Perez Giraldo, Gina S; Jimenez, Millenia; Miller, Janet; Lopez, Melissa; Hanson, Barbara A; Bawa, Aasheeta P; Batra...

Background A variety of symptoms, particularly cognitive, psychiatric and neurological symptoms, may persist for a long time among individuals recovering from COVID-19. However, the underlying mechanism of these brain abnormalities remains unclear. This study aimed to investigate the long-term...

Bystander activated CD8+ T cells mediate neuropathology during viral infection via antigen-independent cytotoxicity Nature, open access: https://www.nature.com/articles/s41467-023-44667-0 Abstract Although many viral infections are linked to the development of neurological disorders, the...

Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons Abstract COVID-19 has represented an issue for global health since its outbreak in March 2020. It is now evident that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...

Abstract Purpose of the review Persistent infections capable of causing central nervous system (CNS) complications months or years after the initial infection represent a major public health concern. This concern is particularly relevant considering the ongoing coronavirus disease 2019...

SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 Zhouyi Rong; Hongcheng Mai; Saketh Kapoor; Victor Puelles; Jan Czogalla; Julia Schaedler; Jessica Vering; Claire Delbridge; Hanno Steinke...

https://www.nature.com/articles/s41591-022-02001-z Twitter thread about this study

Paroxysmal exercise-induced neurological symptoms (PENS) encompass a wide spectrum of clinical phenomena commonly presenting during childhood and characteristically elicited by physical exercise. Interestingly, few shared pathogenetic mechanisms have been identified beyond the well-known entity...