neutrophil extracellular traps

Intestinal flagellin drives multisystem inflammation through TLR5-IL-15-ARA axis BACKGROUND Systemic inflammatory diseases including rheumatoid arthritis (RA), ankylosing spondylitis (AS), IBD and long covid share convergent multi-organ phenotypes. Long covid provides a tractable model for...

Dynamic Coagulation Function Changes in COVID-19 Survivors With Coronary Artery Disease Coronary artery disease (CAD) and Coronavirus disease 2019 (COVID-19) are both associated with a hypercoagulable state, yet the long-term interaction between these prothrombotic conditions remains poorly...

De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection Abstract Background Glucose metabolism disorders (GMDs) are established risk factors for severe COVID-19, but increasing evidence indicates that...

Endovascular profiles linked to neutrophil activation in children and young adults with long COVID Endovascular symptoms are among the most debilitating long COVID symptoms; however, underlying mechanisms are unclear. Children and young adults with long COVID, an understudied population, offer...

NET Biomarkers in COVID-19 and Post-COVID Syndrome: a Comprehensive Analysis SARS-CoV-2 triggers immune responses, including neutrophil activation and neutrophil extracellular trap (NET) release, contributing to COVID-19 severity. A significant proportion of patients experience persistent or...

Abstract The Persistence of SARS-CoV-2 in tissues has been proposed as a driver of prolonged symptoms in long COVID. Pulmonary rehabilitation with exercise training is a well-established intervention for improving symptoms, functional capacity, and inflammation in chronic cardiorespiratory...

Extracellular Vesicle-Delivered tRF-His-GTG-1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID-19 Immunometabolism and neutrophil extracellular traps (NETs) play pivotal roles in the pathogenesis of coronavirus disease 2019 (COVID-19) and its postacute sequelae. However, the...

Sars-Cov-2 spike protein and plasma from COVID-19 patients induce extracellular traps by myeloid-derived suppressor cells INTRODUCTION Polymorphonuclear-myeloid-derived suppressor cells (PMN-MDSC) are elevated in COVID-19 patients, playing a crucial role in suppressing the SARS-CoV-2 specific...

Abstract Coagulation, although primarily regulated by platelets, endothelial cells, and clotting factors, can also be influenced by molecules that are not traditionally seen as related to coagulation, including cytokines, hormones, metabolites, reactive oxygen species, acute phase reactants, and...

DecodeMe Candidate Gene CHROMOSOME 13 Chr13 contained no Tier 1 genes and one Tier 2 gene. ******************** OLFM4 (Tier 2) • Protein: Olfactomedin-4. UniProt. GeneCards. • Molecular function: OLFM4 facilitates cell adhesion, most probably through interaction with cell surface lectins...

Neutrophil extracellular traps and macrophage activation contibute to thrombosis and post-covid syndrome in SARS-CoV-2 infection Serrano-Gonzalo, Irene; Menéndez-Jandula, Bárbara; Franco-García, Esther; Arévalo-Vargas, Isidro; Lahoz-Gil, Calos; Latre, Paz; Roca-Esteve, Sonia; Köhler, Ralf; López...

Exercise intensity and training alter the innate immune cell type and chromosomal origins of circulating cell-free DNA in humans Rodrigues, Kameron B.; Weng, Ziming; Graham, Zachary A.; Lavin, Kaleen; McAdam, Jeremy; Tuggle, S. Craig; Peoples, Brandon; Seay, Regina; Yang, Sufen; Bamman, Marcas...

Neutrophil Elastase, Neuron-Specific Enolase, and S100B Protein as Potential Markers of Long-Term Complications Caused by COVID-19 in Patients with Type 2 Diabetes Mellitus T2DM and Advanced Stage of Diabetic Nephropathy NfT2DM—Observational Studies Rabczyński, Maciej; Chwałek, Sandra...

Association of vascular netosis with COVID-19 severity in asymptomatic and symptomatic patients Suman Kapoor; Lucia Mihalovičová; Ekaterina Pisareva; Brice Pastor; Alexia Mirandola; Benoit Roch; Joe Bryant; Anna Philip Princy; Salem Chouaib; Alain Roger Thierry We examined from a large...

Inflammation-, immunothrombosis,- and autoimmune-feedback loops may lead to persistent neutrophil self-stimulation in long COVID Alain R. Thierry; Dominique Salmon Understanding the pathophysiology of long COVID is one of the most intriguing challenges confronting contemporary medicine. Despite...

Now published, see post #8 ------------------------------------------- Circulating microclots are structurally associated with Neutrophil Extracellular Traps and their amounts are strongly elevated in long COVID patients Etheresia Pretorius¹, Alain THIERRY², Cynthia Sanchez³, Tram Ha⁴, Brice...

Blood test that can rapidly identify sepsis being trialled in UK (msn.com)

Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time Giuseppe Gianini Figueirêdo Leite; Milena Karina Colo Brunialti; Paula M. Peçanha-Pietrobom; Paulo R. Abrão Ferreira; Jaquelina Sonoe Ota-Arakaki; Edecio...

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants Jeremy P. Gygi; Cole Maguire; Ravi K. Patel; Pramod Shinde; Anna Konstorum; Casey P. Shannon; Leqi Xu; Annmarie Hoch; Naresh Jayavelu; IMPACC...

Now published - details here ********** Preprint Characterization of Unique Pathological Features of COVID-Associated Coagulopathy: Studies with AC70 hACE2 Transgenic Mice Highly Permissive to SARS-CoV-2 Infection Aleksandra K Drelich; Kempaiah Rayavara; Jason Hsu; Panatda Saenkham-Huntsinger...