orthostatic intolerance

Shared autonomic phenotype of long COVID and myalgic encephalomyelitis/chronic fatigue syndrome Peter Novak; David M Systrom; Alexandra Witte; Sadie P Marciano; Donna Felsenstein; Jeff M Milunsky; Aubrey Milunsky; Joel Krier; Mark C Fishman INTRODUCTION Long COVID and myalgic...

Sleep-disordered Breathing and Hypotension Christian Guilleminault, John L. Faul, Riccardo Stoohs https://www.atsjournals.org/doi/10.1164/ajrccm.164.7.2011036 (PDF available) Abstract We investigated the presence of low blood pressure (BP) in 4,409 subjects referred for overnight...

Impact of COVID‑19 infection on subsequent prescriptions of autonomic dysfunction pharmacotherapy: a nationwide propensity‑score‑matched Cohort study in Japan Daisuke Miyamori; Masanori Ito BACKGROUND Autonomic dysfunction, including orthostatic hypotension and postural tachycardia syndrome...

Postural orthostatic tachycardia syndrome (POTS) is a complex disorder mainly of orthostatic intolerance, often accompanied by a spectrum of symptoms related to autonomic nervous system dysfunction. Although the diagnostic criteria require an orthostatic challenge test, the associated symptom...

Journal of Clinical Medicine: Special Issue Deadline for manuscript submissions: 20 January 2026 Special Issue Information Dear Colleagues, Postural orthostatic tachycardia syndrome (POTS), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are complex syndromes caused...

Background: Orthostatic intolerance syndromes such as Orthostatic Hypotension (OH) and Postural Orthostatic Tachycardia Syndrome (PoTS) are common symptoms seen in post-infection conditions and other neurological conditions with autonomic dysfunction. The 10-min Lean Test (LT) is an objective...

Characterization of sympathicotonia in post-covid condition long covid and healthy controls using long-term electrodermal activity EDA follow-up PURPOSE After SARS-CoV-2 infection, some patients develop post-COVID condition (PCC), often associated with sympathicotonia. This study aimed to...

Abstract Background Cardiovascular autonomic disorders (CAD) were described following COVID-19 infection and vaccination, but previous reports were limited in size and follow-up. Here, we aimed to investigate the type and frequency of newly diagnosed and exacerbated CAD following COVID-19...

Evaluating the risk and risk factors of dysautonomia as a post-acute sequelae of COVID-19: a secondary analysis of a matched case–control dataset BACKGROUND A significant proportion of patients presenting with post-acute sequelae of COVID-19 (PASC) have been found to meet diagnostic criteria...

Water drinking as a treatment for orthostatic syndromes John R Shannon, Andre Diedrich, Italo Biaggioni, Jens Tank, Rose Marie Robertson, David Robertson, Jens Jordan Abstract Purpose: Water drinking increases blood pressure in a substantial proportion of patients who have severe...

Sex-related cardiometabolic differences in ME/CFS patients Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, debilitating, and multisystem disease that affects more females than males. Core symptoms include persistent fatigue, post-exertional malaise (PEM), unrefreshing...

Time-restricted eating improves quality of life, heart rate, and mitochondrial function in patients with postural orthostatic tachycardia syndrome. An open-label pilot study Postural orthostatic tachycardia syndrome (POTS) is characterized by an abnormal increase in heart rate upon standing...

Prevalence and Clinical Impact of Postural Orthostatic Tachycardia Syndrome in Highly Symptomatic Long COVID BACKGROUND The incidence of postural orthostatic tachycardia syndrome (POTS) in long COVID has been a growing concern since the first cases were reported in 2021. The aim of this study...

Hormonal Fluctuations and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in Women: The Role of Menstrual Cycle and Menopause Mehak Khan, Sidra Anees, Muhammad Muthar Anees, Komal Khalid Chaudhry, Syeda Marium Rashid Zaidi, Vishan Das, Rimal Rashid [Line breaks added] Abstract Myalgic...

Abstract Background/Objectives: Symptoms of autonomic dysfunction are common in infection-associated chronic conditions and illnesses (IACCIs), including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This study aimed to evaluate autonomic symptoms and their impact on ME/CFS...

Abstract: Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and debilitating condition with a large proportion of patients that experience orthostatic intolerance (OI). This systematic review aimed to assess whether cerebral blood flow (CBF) is reduced in ME/CFS...

Dynamic cerebral autoregulation in people with mild cognitive impairment Laura K Fitzgibbon-Collins; Michael Borrie; Sue Peters; J Kevin Shoemaker; Jaspreet Bhangu Altered cerebrovascular hemodynamics and low cerebral perfusion contribute to the development and progression of dementia. Dynamic...

Long-COVID Postural Tachycardia Syndrome: A deep phenotyping study Nicholas W Larsen; Jannika V Machnik; Jordan Seliger; Ruba Shaik; Christopher H Gibbons; Paul J Utz; Maarten G Lansberg; Srikanth Muppidi; Safwan Jaradeh; Mitchell G Miglis BACKGROUND Postural tachycardia syndrome (POTS) has...

Circulating Autoantibodies Against Vasoactive Biomarkers Related to Orthostatic Intolerance in Long COVID Patients Compared to No-Long-COVID Populations: A Case-Control Study Emilie Han, Katrin Müller-Zlabinger, Ena Hasimbegovic, Laura Poschenreithner, Nina Kastner, Babette Maleiner, Kevin...

Abstract Cerebral blood flow (CBF) is vital for delivering oxygen and nutrients to the brain. Many forms of orthostatic intolerance (OI) involve impaired regulation of CBF in the upright posture, which results in disabling symptoms that decrease quality of life. Because CBF is not easy to...