orthostatic intolerance

https://www.mdpi.com/1648-9144/59/12/2153 Worsening Symptoms Is Associated with Larger Cerebral Blood Flow Abnormalities during Tilt-Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) by C. (Linda) M. C. van Campen 1,*, Peter C. Rowe 2 and Frans C. Visser 1 1 Stichting...

A clinical geneticist believes that a rare variant in the SCN9A gene could be responsible for at least a part of my symptoms. The variant is extremely rare (1 in 1.4 million alleles) and not found in healthy people. The gene is associated with small fibre neuropathy which would fit, but there...

This is the preprint. See post #4 for the published paper Augmentation of Anaerobic Pentose Phosphate Pathway Dysregulates Tetrahydrobiopterin Metabolism in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) Patients with Orthostatic Intolerance: A Pilot Study Sarojini Bulbule, Carl...

Autonomic Manifestations of Long-COVID Syndrome Hira, Rashmin; Karalasingham, Kavithra; Baker, Jacquie R.; Raj, Satish R. Purpose of Review Long-COVID is a novel condition emerging from the COVID-19 pandemic. Long-COVID is characterized by symptoms commonly seen in autonomic disorders including...

'Many patients with neurogenic orthostatic hypotension also have hypertension in the supine position. The BP can be extremely labile, resembling a volatile stock market chart.' Abstract Symptoms of autonomic dysfunction are prevalent and can be very debilitating, reducing the quality of life...

Influence of end-tidal CO2 on cerebral blood flow during orthostatic stress in controls and adults with myalgic encephalomyelitis/chronic fatigue syndrome C. (Linda) M. C. van Campen; Peter C. Rowe; Freek W. A. Verheugt; Frans C. Visser Brain perfusion is sensitive to changes in CO2 levels (CO2...

The Long-COVID autonomic syndrome in hospitalized patients: A one-year prospective cohort study Stefano Rigo; Franca Barbic; Kareem Khalaf; Andrea Bisoglio; Margherita Pani; Maura Minonzio; Luca Rinaldi; Michele Ciccarelli; Maria Grazia Bordoni; Paolo Verzeletti; Fabio Badilini; Stefanos...

High proportions of post-exertional malaise and orthostatic intolerance in people living with post-COVID-19 condition: the PRIME post-COVID study Demi ME Pagen; Maarten Van Herck; Celine JA van Bilsen; Stephanie Brinkhues; Kevin Konings; Casper DJ den Heijer; Martijn A Spruit; Christian JPA...

Abstract Purpose Orthostatic hypotension is a common condition with heterogeneous and, in many cases, unclear underlying pathophysiology. Frequent symptoms are syncope and falls with a strong impact on daily life. A two-generation family with eight individuals segregating early-onset severe...

Why telling pwOI to just drink more water might not be as helpful as you'd think. I feel this Instagram post is worth a read, including the comments.

Abstract Background Many patients with postural orthostatic tachycardia syndrome (POTS) are hypovolemic with plasma volume deficits of 10–30 %. Some also have low levels of aldosterone and diminished aldosterone-renin ratios despite elevations in angiotensin II, pointing to potential adrenal...

Abstract Purpose Orthostatic intolerance commonly occurs following immobilization or space flight. We hypothesized that daily artificial gravity training through short-arm centrifugation could help to maintain orthostatic tolerance following head-down tilt bedrest, which is an established...

Full title: Cognitive impairment in post-acute sequelae of COVID-19 and short duration myalgic encephalomyelitis patients is mediated by orthostatic hemodynamic changes Introduction: Cognitive impairment is experienced by people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)...

Full title: Cognitive functioning in postural orthostatic tachycardia syndrome among different body positions: a prospective pilot study (POTSKog study) Abstract Purpose Approximately 96% of patients with postural orthostatic tachycardia syndrome (PoTS) report cognitive complaints. We...

Usefulness of an abnormal cardiovascular response during low-grade head-up tilt-test for discriminating adolescents with chronic fatigue from healthy controls Vegard Bruun Wyller 1, Reidar Due, J Philip Saul, Jan P Amlie, Erik Thaulow 2007 https://pubmed.ncbi.nlm.nih.gov/17398200/ Hemodynamic...

Introduction: During a standard 70-degree head-up tilt test, 90% of adults with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) develop an abnormal reduction in cerebral blood flow (CBF). A 70-degree test might not be tolerated by young ME/CFS patients because of the high incidence...

Detecting Orthostatic Intolerance in Long COVID in a Clinic Setting Isaac, Robert Oliver; Corrado, Joanna; Sivan, Manoj Introduction: A likely mechanism of Long COVID (LC) is dysautonomia, manifesting as orthostatic intolerance (OI). In our LC service, all patients underwent a National...

Orthostatic chronotropic incompetence in patients with myalgic encephalomyelitis/chronic fatigue syndrome ME/CFS van Campen; Verheugt; Rowe; Visser Background: Orthostatic intolerance (OI) is a core diagnostic criterion in myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS). The...

Abstract Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a multisystem chronic illness characterized by severe muscle fatigue, pain, dizziness, and brain fog. Many patients with ME/CFS experience orthostatic intolerance (OI), which is characterized by frequent dizziness...

Abstract Background: Cerebral hypoperfusion before syncope has been shown in patients with chronic orthostatic intolerance (OI) without tachycardia, but it is unknown if an initial decrease of cerebral blood flow velocity (CBFv) could be related to the vasovagal response (VVR) to head-up tilt...