orthostatic intolerance

Background: Some patients with acute COVID-19 are left with persistent, debilitating fatigue, cognitive impairment (“brain fog”), orthostatic intolerance (OI) and other symptoms (“Long COVID”). Many of the symptoms are like those of other post-infectious fatigue syndromes and may meet criteria...

Full title: Implantable neurostimulators for neurogenic orthostatic hypotension: the wave of the future? and Other updates on recent autonomic research, 2022, Mitchell G. Miglis et al Multiple system atrophy (MSA) is the most aggressive neurodegenerative disease of alpha-synuclein deposition...

The YouTube link below relates to the April 8 online talk and Q&A with Professor Frans Visser and Dr Linda van Campen who are both Dutch experts/cardiologists/clinicians/researchers. This talk and Q&A session was arranged by the Irish ME Trust and the Irish ME/CFS Association. Q&A was edited...

Abstract Purpose Bolus water drinking, at room temperature, has been shown to improve orthostatic tolerance (OT), probably via sympathetic activation; however, it is not clear whether the temperature of the water bolus modifies the effect on OT or the cardiovascular responses to orthostatic...

Salt from the autonomic perspective, 2022, William P Cheshire - editorial https://www.sciencedirect.com/science/article/pii/S1566070222000297?dgcid=author#bb0005

Abstract Background: Patients with PASC often report symptoms of orthostatic intolerance and autonomic dysfunction. Numerous case reports link Postural Orthostatic Tachycardia Syndrome (POTS) to PASC. No prospective analysis has been performed. Objective: We performed head-up tilt table (HUTT)...

Women are more prone to orthostatic intolerance compared to men and have a greater vasodilatory capacity. We investigated the hypothesis that women would have greater peripheral flow-mediated dilation (FMD) while in the upright posture compared to men, which could contribute to this phenomenon...

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03289-8 Benjamin H. Natelson Jin-Mann S. Lin Michelle Blate Sarah Khan Yang Chen Elizabeth R. Unger Open access Background Orthostatic intolerance-OI is common in Myalgic Encephalomyelitis/Chronic Fatigue...

Abstract Purpose Previous studies demonstrated M2 muscarinic acetylcholine receptor-activating autoantibodies (M2R-AAb) were present in some patients with postural tachycardia syndrome (POTS). This study examines how these autoantibodies might contribute to the pathophysiology of POTS, and...

Gluten-free diet in postural orthostatic tachycardia syndrome (POTS), 2022, Zha et al Abstract Objectives Postural orthostatic tachycardia syndrome (POTS) is a chronic disorder of the autonomic nervous system that is associated with orthostatic intolerance (OI) and gastrointestinal (GI)...

Abstract Background and objectives: Orthostatic intolerance (OI) is a clinical condition in which symptoms worsen upon assuming and maintaining upright posture and are ameliorated by recumbency. OI has a high prevalence in patients with myalgic encephalomyelitis/chronic fatigue syndrome...

Compression Stockings Improve Cardiac Output and Cerebral Blood Flow during Tilt Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Patients: A Randomized Crossover Trial Abstract Background and Objectives: Orthostatic intolerance (OI) is a clinical condition in which...

Orthostatic Symptoms and Reductions in Cerebral Blood Flow in Long-Haul COVID-19 Patients: Similarities with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Abstract Background and Objectives: Symptoms and hemodynamic findings during orthostatic stress have been reported in both long-haul...

Highlights Long COVID symptoms include fatigue, brain fog, anosmia, dysgeusia, orthostatic intolerance Long COVId symptoms overlap with those of chronic fatigue syndrome (ME/CFS) and POTS. Reduced cerebral blood flow is a feature of dysautonomia in ME/CFS and POTS. Stellate ganglion block...

Orthostatic intolerance syndromes after hematopoietic cell transplantation: clinical characteristics and therapeutic interventions in a single-center experience Abstract Background Hematopoietic cell transplantation (HCT) is an established and potentially curative therapeutic option for...

Background and Objective: Migraineurs often complain of orthostatic intolerance (OI), and its recognition is vital to appropriate treatment. This study attempts to identify and characterize autonomic dysfunction, comparing a sample of migraineurs with OI with a sample of migraineurs without...

Abstract Salt supplementation is a common non-pharmacological approach to the management of recurrent orthostatic syncope or presyncope, particularly for patients with vasovagal syncope (VVS) or postural orthostatic tachycardia syndrome (POTS), although there is limited consensus on the optimal...

In conclusion, meals do matter in the evaluation and treatment of POTS. There are significant postprandial symptoms in POTS patients, which are related to exaggerated postprandial tachycardia. Possible mechanisms include enhanced splanchnic blood pooling, an increased secretion of vasoactive...

Dr Jenny Butler, Consultant Physician - General Medicine, at Christchurch Hospital, is joining us online on Wed, 10th Nov 1.30pm to talk about Orthostatic Intolerance. Many people with ME/CFS (Myalgic Encephalomyelitis /Chronic Fatigue Syndrome) experience triggering or worsening of symptoms...

Abstract Background: Postural tachycardia syndrome (POTS) is a form of autonomic dysregulation and is characterized by an excessive heart rate (HR) increment upon the upright body position while blood pressure is maintained. Patients experience typical symptoms of orthostatic intolerance such as...