APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases
Artur Shvetcov, Erik C. B. Johnson, Laura M. Winchester, Keenan A. Walker, Heather M. Wilkins, Terri G. Thompson, Jeffrey D. Rothstein, Varsha Krish, Farhad B. Imam, The Global Neurodegeneration Proteomics...
https://www.news-medical.net/news/20250701/Clinical-trial-examines-whether-Ambroxol-can-slow-dementia-in-people-with-Parkinsons.aspx
research paper:
https://jamanetwork.com/journals/jamaneurology/article-abstract/2835760
Objective.
To study the prevalence and associations of chronic fatigue syndrome (CFS) with other clinical and neuropsychological manifestations of Parkinson’s disease (PD) and serum inflammatory markers and genetic polymorphisms.
Materials and methods.
The study involved 533 patients with...
Proximity to Golf Courses and Risk of Parkinson Disease
Brittany Krzyzanowski, Aidan F. Mullan, E. Ray Dorsey, Sai Shivani Chirag, Pierpaolo Turcano, Emanuele Camerucci, James H. Bower, Rodolfo Savica
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Key Points
Question
Does living within proximity to a golf course...
Possible linking and treatment between Parkinson's disease and inflammatory bowel disease: a study of Mendelian randomization based on gut-brain axis
Beiming Wang, Xiaoyin Bai, Yingmai Yang, Hong Yang
Background: Mounting evidence suggests that Parkinson's disease (PD) and inflammatory bowel...
https://wapo.st/3TFLe3l
Researchers found that people with upper gastrointestinal conditions were far more likely to develop Parkinson’s disease later in life
New-onset Parkinsonism as a Covid-19 infection sequela: A systematic review and meta-analysis
Published online 8 Aug 2022
Syed Sami Ali, Afshan Mumtaz, Mohammad Aadil Qamar, Sameer Saleem Tebha, Azma Parhin, Mehwish Butt, Mohammad Yasir Essare
Background
There remains a scarcity of literature...
α-synuclein Seeding Activity in the Olfactory Mucosa in COVID-19
Medical University of Innsbruck
Innsbruck, Austria
Estimated study completion: 2023-12-31
Brief Summary
Loss of the sense of smell is a characteristic feature of COVID-19 and likely related to viral invasion of the olfactory...
Skin Biopsy Detection of Phosphorylated α-Synuclein in Patients With Synucleinopathies
Authors
Abstract
Importance Finding a reliable diagnostic biomarker for the disorders collectively known as synucleinopathies (Parkinson disease [PD], dementia with Lewy bodies [DLB], multiple system...
A potential landmark genetic association study for the neurodegenerative disorder Parkinson’s has uncovered a new risk variant. The team, which included scientists from the University Medical Center Utrecht, Indiana University School of Medicine, and UMass Chan Medical School, combined whole...
Plasma proteomics identify biomarkers predicting Parkinson’s disease up to 7 years before symptom onset
Jenny Hällqvist, Michael Bartl, Mohammed Dakna, Sebastian Schade, Paolo Garagnani, Maria-Giulia Bacalini, Chiara Pirazzini, Kailash Bhatia, Sebastian Schreglmann, Mary Xylaki, Sandrina Weber...
Abstract
Multiple studies describe prodromal, non-motor dysfunctions that affect the quality of life of patients who subsequently develop Parkinson's disease (PD). These prodromal dysfunctions comprise a wide array of autonomic issues, including severe gastrointestinal (GI) motility disorders...
The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics
Pileggi; Parmar; Elkhatib; Stewart; Alecu; Côté; Bennett; Sandhu; Cuperlovic-Culf; Harper
SARS-CoV-2 infection is associated with both acute and post-acute neurological symptoms. Emerging evidence...
Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs
Todkar, Kiran; Chikhi, Lilia; Desjardins, Véronique; El-Mortada, Firas; Pépin, Geneviève; Germain, Marc
Most cells constitutively secrete mitochondrial DNA and proteins in...
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