parkinsons

SARS-CoV-2 Spike Protein S1 Domain Accelerates α-Synuclein Phosphorylation and Aggregation in Cellular Models of Synucleinopathy Wang, Jiannan; Dai, Lijun; Deng, Min; Xiao, Tingting; Zhang, Zhaohui; Zhang, Zhentao The 2019 novel coronavirus disease (COVID-19) is an infectious disease that began...

Mitochondrial DNA damage triggers spread of Parkinson’s disease-like pathology Tresse, Emilie; Marturia-Navarro, Joana; Sew, Wei Qi Guinevere; Cisquella-Serra, Marina; Jaberi, Elham; Riera-Ponsati, Lluis; Fauerby, Natasha; Hu, Erling; Kretz, Oliver; Aznar, Susana; Issazadeh-Navikas, Shohreh In...

https://wapo.st/3PDbBnB If the hypothesis that misfolded proteins start in the gut and travel to the brain is proved, it could lead to early detection and treatment of Parkinson’s

Retinal Optical Coherence Tomography Features Associated With Incident and Prevalent Parkinson Disease Siegfried Karl Wagner; David Romero-Bascones; Mario Cortina-Borja; Dominic J Williamson; Robbert R Struyven; Yukun Zhou; Salil Patel; Rimona S Weil; Chrystalina A Antoniades; Eric J Topol...

Title: Cutaneous α-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease Authors: Christopher Gibbons, Ningshan Wang 1, Sharika Rajan 1, Drew Kern 1, Jose-Alberto Palma 1, Horacio Kaufmann 1, Roy Freeman 2 Abstract: Background and objectives: Multiple system...

SARS-COV-2 spike protein fragment eases amyloidogenesis of α-synuclein Chesney, Andrew D.; Maiti, Buddhadev; Hansmann, Ulrich H. E. Parkinson’s Disease is accompanied by presence of amyloids in the brain formed of α-synuclein chains. Correlation between COVID-19 and the onset of Parkinson’s...

Comorbidity genetic risk and pathways impact SARS-CoV-2 infection outcomes Jaros, Rachel K.; Fadason, Tayaza; Cameron-Smith, David; Golovina, Evgeniia; O’Sullivan, Justin M. Understanding the genetic risk and mechanisms through which SARS-CoV-2 infection outcomes and comorbidities interact to...

JAMA Neurol. Published online May 15, 2023. doi:10.1001/jamaneurol.2023.1168 https://jamanetwork.com/journals/jamaneurology/article-abstract/2805037 Key points Question Is Parkinson disease risk increased in military service members who were stationed at Marine Corps Base Camp Lejeune, North...

https://www.science.org/content/article/twist-fate-what-happens-when-top-parkinson-s-researcher-gets-disease

Researchers discover a potential cause of Parkinson’s disease | University of Helsinki “Our findings are significant, as the cause of Parkinson’s disease has gone unknown despite attempts to identify it throughout the last two centuries. The findings indicate that specific strains of...

Medical Research Foundation https://www.medicalresearchfoundation.org.uk/news/the-role-of-mitochondria-in-parkinsons-disease

Alzheimer's and Parkinson's could be halted by a protein that helps hedgehogs hibernate (msn.com)

Background: A growing body of evidence showed that gut microbiota dysbiosis might be associated with the pathogenesis of Parkinson’s disease (PD). Microbiota-targeted interventions could play a protective role in PD by regulating the gut microbiota-gut-brain axis. Sodium butyrate (NaB) could...

https://www.uclh.nhs.uk/news/cough-medicine-offers-hope-new-treatment-slow-progression-parkinsons-disease

A Case Report: Multifocal Necrotizing Encephalitis and Myocarditis after BNT162b2 mRNA Vaccination against COVID-19 Michael Mörz The current report presents the case of a 76-year-old man with Parkinson’s disease (PD) who died three weeks after receiving his third COVID-19 vaccination. The...

Abstract Background and Objectives: Short-chain fatty acids (SCFAs) are gut microbial metabolites that promote the disease process in a rodent model of Parkinson’s disease (PD), but fecal levels of SCFAs in PD patients are reduced. Simultaneous assessments of fecal and plasma SCFA levels, and...

In mice. Abstract Objective Idiopathic Parkinson’s disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation...

Highlights Functional Neurological Disorder (FND) and Somatic Symptom Disorder (SSD) can be manifestations of PD and DLB. FND/SSD appear at prodromal/early stages of PD, then subside with motor worsening. In cognitively impaired patients, FND/SSD may evolve into somatic delusions. Abstract The...

An article from neuroscience news. Interesting as dopamine has been highlighted in some research in ME and dopamine mediation ( agonists etc) has had effect for some . https://neurosciencenews.com/mitochondria-parkisons-19057/amp/

https://www.prnewswire.com/news-releases/bluerock-therapeutics-receives-fda-fast-track-designation-for-da01-in-the-treatment-of-advanced-parkinsons-disease-301336295.html Probably something like this will be needed to cure MECFS.