parkinsons

Retinal Optical Coherence Tomography Features Associated With Incident and Prevalent Parkinson Disease Siegfried Karl Wagner; David Romero-Bascones; Mario Cortina-Borja; Dominic J Williamson; Robbert R Struyven; Yukun Zhou; Salil Patel; Rimona S Weil; Chrystalina A Antoniades; Eric J Topol...

Title: Cutaneous α-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease Authors: Christopher Gibbons, Ningshan Wang 1, Sharika Rajan 1, Drew Kern 1, Jose-Alberto Palma 1, Horacio Kaufmann 1, Roy Freeman 2 Abstract: Background and objectives: Multiple system...

SARS-COV-2 spike protein fragment eases amyloidogenesis of α-synuclein Chesney, Andrew D.; Maiti, Buddhadev; Hansmann, Ulrich H. E. Parkinson’s Disease is accompanied by presence of amyloids in the brain formed of α-synuclein chains. Correlation between COVID-19 and the onset of Parkinson’s...

Comorbidity genetic risk and pathways impact SARS-CoV-2 infection outcomes Jaros, Rachel K.; Fadason, Tayaza; Cameron-Smith, David; Golovina, Evgeniia; O’Sullivan, Justin M. Understanding the genetic risk and mechanisms through which SARS-CoV-2 infection outcomes and comorbidities interact to...

JAMA Neurol. Published online May 15, 2023. doi:10.1001/jamaneurol.2023.1168 https://jamanetwork.com/journals/jamaneurology/article-abstract/2805037 Key points Question Is Parkinson disease risk increased in military service members who were stationed at Marine Corps Base Camp Lejeune, North...

https://www.science.org/content/article/twist-fate-what-happens-when-top-parkinson-s-researcher-gets-disease

Researchers discover a potential cause of Parkinson’s disease | University of Helsinki “Our findings are significant, as the cause of Parkinson’s disease has gone unknown despite attempts to identify it throughout the last two centuries. The findings indicate that specific strains of...

Medical Research Foundation https://www.medicalresearchfoundation.org.uk/news/the-role-of-mitochondria-in-parkinsons-disease

Alzheimer's and Parkinson's could be halted by a protein that helps hedgehogs hibernate (msn.com)

Background: A growing body of evidence showed that gut microbiota dysbiosis might be associated with the pathogenesis of Parkinson’s disease (PD). Microbiota-targeted interventions could play a protective role in PD by regulating the gut microbiota-gut-brain axis. Sodium butyrate (NaB) could...

https://www.uclh.nhs.uk/news/cough-medicine-offers-hope-new-treatment-slow-progression-parkinsons-disease

A Case Report: Multifocal Necrotizing Encephalitis and Myocarditis after BNT162b2 mRNA Vaccination against COVID-19 Michael Mörz The current report presents the case of a 76-year-old man with Parkinson’s disease (PD) who died three weeks after receiving his third COVID-19 vaccination. The...

Abstract Background and Objectives: Short-chain fatty acids (SCFAs) are gut microbial metabolites that promote the disease process in a rodent model of Parkinson’s disease (PD), but fecal levels of SCFAs in PD patients are reduced. Simultaneous assessments of fecal and plasma SCFA levels, and...

In mice. Abstract Objective Idiopathic Parkinson’s disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation...

Highlights Functional Neurological Disorder (FND) and Somatic Symptom Disorder (SSD) can be manifestations of PD and DLB. FND/SSD appear at prodromal/early stages of PD, then subside with motor worsening. In cognitively impaired patients, FND/SSD may evolve into somatic delusions. Abstract The...

An article from neuroscience news. Interesting as dopamine has been highlighted in some research in ME and dopamine mediation ( agonists etc) has had effect for some . https://neurosciencenews.com/mitochondria-parkisons-19057/amp/

https://www.prnewswire.com/news-releases/bluerock-therapeutics-receives-fda-fast-track-designation-for-da01-in-the-treatment-of-advanced-parkinsons-disease-301336295.html Probably something like this will be needed to cure MECFS.

Link to press article with Trichloroethylene bring a known risk factor for developing Parkinsons disease. Given other chemical associations with ME ( eg orgsnophosphates) this may be one to watch...

Abstract: Since the initial reports of COVID-19 in December 2019, the world has been gripped by the disastrous acute respiratory disease caused by the SARS-CoV-2 virus. There are an ever-increasing number of reports of neurological symptoms in patients, from severe (encephalitis), to mild...

full article https://www.express.co.uk/life-style/health/1324319/parkinsons-disease-symptoms-signs-feet-stiffness-foot-dystonia