Cytosolic interaction with RNA-helicase DDX39A titrates viral RNA G-quadruplex mediated α-Synuclein amyloidogenesis
Abstract
Amyloid aggregates of α -Synuclein are hallmark of Parkinsons Disease (PD) and related neurodegenerative diseases. α -Synuclein, being an non-canonical RNA-binding...
Smoking, Exhaled Carbon Monoxide, and Risk of Parkinson Disease
Abstract
Importance Smoking has been associated with lower risks of Parkinson disease (PD) in epidemiological studies, but the underlying mechanisms remain poorly elucidated.
Objective
To investigate the association of exhaled...
Lipid membrane remodeling by myristic acid treatment reverses Parkinson’s disease α-synuclein phenotypes in patient neurons
Despite the lipid-rich nature of the brain, defining the role of lipid metabolism in neurodegenerative disease and targeting lipid metabolic pathways for disease...
Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease
Abstract
Parkinson’s disease is caused by the loss of dopamine neurons, causing motor symptoms. Initial cell therapies using fetal tissues showed promise but had complications and ethical concerns1,2,3,4,5...
Parkinson’s disease as a somato-cognitive action network disorder
Parkinson’s disease (PD) is an incurable neurological disorder that often begins insidiously with sleep disturbances and somatic symptoms, progressing to whole-body motor and cognitive symptoms1,2,3,4,5. Dysfunction of the...
The proteasome: A key modulator of nervous system function, brain aging, and neurodegenerative disease
Davidson, K., & Pickering, A. M.
Abstract
The proteasome is a large multi-subunit protease responsible for the degradation and removal of oxidized, misfolded, and polyubiquitinated proteins...
I first heard about this in a paywalled reuters article
More info in this press release from a few days ago
Source - Yahoo Finance
There’s also a nature article from earlier in he year but it’s also paywalled.
And some older items from the company website on this technology.
Bayer - Cell...
APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases
Artur Shvetcov, Erik C. B. Johnson, Laura M. Winchester, Keenan A. Walker, Heather M. Wilkins, Terri G. Thompson, Jeffrey D. Rothstein, Varsha Krish, Farhad B. Imam, The Global Neurodegeneration Proteomics...
https://www.news-medical.net/news/20250701/Clinical-trial-examines-whether-Ambroxol-can-slow-dementia-in-people-with-Parkinsons.aspx
research paper:
https://jamanetwork.com/journals/jamaneurology/article-abstract/2835760
Objective.
To study the prevalence and associations of chronic fatigue syndrome (CFS) with other clinical and neuropsychological manifestations of Parkinson’s disease (PD) and serum inflammatory markers and genetic polymorphisms.
Materials and methods.
The study involved 533 patients with...
Proximity to Golf Courses and Risk of Parkinson Disease
Brittany Krzyzanowski, Aidan F. Mullan, E. Ray Dorsey, Sai Shivani Chirag, Pierpaolo Turcano, Emanuele Camerucci, James H. Bower, Rodolfo Savica
[Line breaks added]
Key Points
Question
Does living within proximity to a golf course...
Possible linking and treatment between Parkinson's disease and inflammatory bowel disease: a study of Mendelian randomization based on gut-brain axis
Beiming Wang, Xiaoyin Bai, Yingmai Yang, Hong Yang
Background: Mounting evidence suggests that Parkinson's disease (PD) and inflammatory bowel...
https://wapo.st/3TFLe3l
Researchers found that people with upper gastrointestinal conditions were far more likely to develop Parkinson’s disease later in life
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