sex differences

Immune system adaptation during gender-affirming testosterone treatment Lakshmikanth, Tadepally; Consiglio, Camila; Sardh, Fabian; Forlin, Rikard; Wang, Jun; Tan, Ziyang; Barcenilla, Hugo; Rodriguez, Lucie; Sugrue, Jamie; Noori, Peri; Ivanchenko, Margarita; Piñero Páez, Laura; Gonzalez, Laura...

Abstract Myalgic Encephalomyelitis (ME; sometimes referred to as chronic fatigue syndrome) is a relatively common and female-biased disease of unknown pathogenesis that profoundly decreases patients' health-related quality-of-life. ME diagnosis is hindered by the absence of robustly-defined and...

Gender Disparities in Neurological Symptoms of Long-COVID: A systematic review and meta-analysis Gorenshtein, Alon; Leibovitch, Liron; Liba, Tom; Stern, Shai; Stern, Yael BACKGROUND Female sex is a known risk factor for long-COVID. With the increasing number of COVID-19 cases, the corresponding...

Spinal cord microglia drive sex differences in ethanol-mediated PGE2-induced allodynia Alexander; Reed; Burton The mechanisms of how long-term alcohol use can lead to persistent pain pathology are unclear. Understanding how earlier events of short-term alcohol use can lower the threshold of...

Sex Modifies the Effect of COVID-19 on Arterial Elasticity Durieux, Jared C.; Zisis, Sokratis N.; Mouchati, Christian; Labbato, Danielle; Abboud, Marc; McComsey, Grace A. There is limited long-term evidence on the effects of COVID-19 on vascular injury between male and female sex. An adult...

Now published - see here ***** An HERV-W ENV transcription in atypical memory B cells linked to COVID-19 evolution and risk for long COVID can express the encoded protein from a ribosome readthrough of mRNA from chromosome X. Joanna Brunel; Julien Paganini; Melissa Galloux; Benjamin Charvet...

Sex differences and immune correlates of Long COVID development, persistence, and resolution Rebecca E Hamlin; Shaun M Pienkos; Leslie Chan; Mikayla A Stabile; Kassandra Pinedo; Mallika Rao; Philip Grant; Hector Bonilla; Marisa Holubar; Upinder Singh; Karen B Jacobson; Prasanna Jagannathan...

Oxidative Stress is a shared characteristic of ME/CFS and Long COVID Vishnu Shankar; Julie Wilhelmy; Basil Michael; Layla Cervantes; Vamsee Mallajosyula; Ronald Davis; Michael Snyder; Shady Younis; William H Robinson; Sadasivan Shankar; Paul Mischel; Hector Bonilla; Mark Davis More than 65...

Towards understanding post-COVID-19 condition: A systematic meta-analysis of transcriptomic alterations with sex-specific insights Rusu; Monfort-Lanzas; Bertran; Barrientos-Riosalido; Solé; Mahmoudian; Aguilar; Briansó; Mohamed; Garcia; Camaron; Auguet BACKGROUND Post COVID-19 Condition (PCC)...

Abstract Males and females experience different trajectories of neuromuscular function across the lifespan, with females demonstrating accelerated deconditioning in later life. We hypothesize that the menopause is a critical period in the female lifespan, during which the dramatic reduction in...

Transcription Profile Analysis of Vastus Lateralis Muscle from Patients with Chronic Fatigue Syndrome T. Pietrangelo; R. Mancinelli; L. Toniolo; G. Montanari; J. Vecchiet; G. Fanò; S. Fulle Chronic fatigue syndrome (CFS) is a disabling condition characterized by unexplained chronic fatigue that...

The Effect of Sex on the Risk of Long-COVID and Cardiovascular Complications in Healthy Patients without Comorbidities: Data from a Polish Long-COVID Cardiovascular PoLoCOV-CVD Study Bielecka-Dabrowa, Agata; Sakowicz, Agata; Gryglewska-Wawrzak, Katarzyna; Kapusta, Joanna; Banach, Maciej...

Post-COVID-19 condition: systemic inflammation and low functional exercise capacity de Castro, Gabriela Salim; Gama, Leonardo R.; Ramos, Alexandre Ferreira; Gatti da Silva, Guilherme; Teixeira, Alexandre Abilio de Souza; Cunha-Neto, Edecio; de Souza, Heraldo Possolo; Marie, Suely K.; Talib, Leda...

Prevalence of autoimmune diseases in functional neurological disorder: influence of psychiatric comorbidities and biological sex Anna Joseph; Gaston Baslet; Mary A O’Neal; Ginger Polich; Irene Gonsalvez; Andrea N Christoforou; Barbara A Dworetzky; Primavera A Spagnolo BACKGROUND Functional...

Abstract The genetic and genomic basis of sex differences in blood pressure (BP) traits remain unstudied at scale. Here, we conducted sex-stratified and combined-sex genome-wide association studies of BP traits using the UK Biobank resource, identifying 1,346 previously reported and 29 new BP...

Accelerated brain age in young to early middle-aged adults after mild to moderate COVID-19 infection Shelli R Kesler; Oscar Y Franco-Rocha; Alexa De La Torre Schutz; Kimberly A. Lewis; Rija Aziz; Michael Brode; Esther Melamed Cognitive decline is a common adverse effect of the Coronavirus...

Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study 605 authors not listed Although it is known that coronavirus disease 2019 can present...

Sex differences in symptomatology and immune profiles of Long COVID Julio Silva; Takehiro Takahashi; Jamie Wood; Peiwen Lu; Sasha Tabachnikova; Jeffrey Gehlhausen; Kerrie Greene; Bornali Bhattacharjee; Valter Silva Monteiro; Carolina Lucas; Rahul Dhodapkar; Laura Tabacof; Mario Pena-Hernandez...

[In mice] Introduction: Post-infection syndromes are characterised by fatigue, muscle pain, anhedonia, and cognitive impairment; mechanistic studies exploring these syndromes have focussed on pathways downstream of Toll-like receptor (TLR) 4 activation. Here, we investigated the mechanistic...

Impact of sex and gender on post-COVID-19 syndrome, Switzerland, 2020 Caroline E Gebhard; Claudia Sütsch; Pimrapat Gebert; Bianca Gysi; Susan Bengs; Atanas Todorov; Manja Deforth; Philipp K Buehler; Alexander Meisel; Reto A Schuepbach; Annelies S Zinkernagel; Silvio D Brugger; Claudio Acevedo...