Abstract:
Current research into mood disorders indicates that circulating immune mediators participating in the pathophysiology of chronic somatic disorders have potent influences on brain function. This paradigm has brought to the fore the use of anti-inflammatory therapies as adjunctive to...
Abstract:
Sufficient evidence is now available to accept the concept that the brain recognizes cytokines as molecular signals of sickness. Clarifying the way the brain processes information generated by the innate immune system is accompanied by a progressive elucidation of the cellular and...
Abstract:
Acute infections are associated with multiple host responses that are triggered by cytokines and correlated to fever, malaise and anorexia. The purpose of this systemic acute phase host reaction („the acute phase response”) is to mobilize nutrients for the increased needs of the...
I thought it might be worthwhile to have a discussion comparing and contrasting the symptoms of an acute infection (a week or two of flu, cold, staph, etc.) and ME/CFS. Viral persistence is often mentioned in discussions of mechanism theories. I personally think there's a good chance ME/CFS is...
I very rarely get sick, but when I do, I don't seem to get a fever. I haven't measured my temperature while sick since I was little, so I can't be sure, but I don't get any "hot" feeling. Even when I was sick for a month straight with something downright awful and my lymph node had me this close...
A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior
Gerwyn Morris, George Anderson, Piotr Galecki, Michael Berk, Michael Maes
Abstract
It is of importance whether myalgic encephalomyelitis/chronic...
Abstract
Pathogen infection causes a stereotyped state of sickness that involves neuronally orchestrated behavioural and physiological changes1,2. On infection, immune cells release a ‘storm’ of cytokines and other mediators, many of which are detected by neurons3,4; yet, the responding neural...
This book represents the papers delivered at the international conference on Illness Behavior held in Toronto in 1985. It should not be considered out of date. It was reprinted in 2013 and so it must be assumed that it is still used either for teaching material or by practitioners.
Illness...
Thought this might be of interest.
https://academic.oup.com/rheumatology/advance-article-abstract/doi/10.1093/rheumatology/kez027/5366191
Sci Hub, https://sci-hub.tw/https://academic.oup.com/rheumatology/advance-article-abstract/doi/10.1093/rheumatology/kez027/5366191
How to explain the evolutionary advantages of Sickness Behavior.
This article is from 2015. Maybe the scientific frontier has advanced since. Anyone knows?
Anyway: I'm a bit impressed. :)
Source: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002276
You will, from time to time, have seen references to "abnormal illness behaviour" in connection with ME or CFS, and these will no doubt have cited the various papers by Mechanic on the subject of "illness behaviour". It seems that this is not quite the full story. There appears to be a lacuna...
Sickness behaviour is a concept that's often referred to in relation to MECFS. I want to see what people think of it. Whether there's something in it, or whether its just a tool used by the mind-over-body crowd.
Here's a rough intro to the concept:
Sickness behaviour refers to the behavioural...
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