spike protein

Detection of S1 spike protein in CD16+ monocytes up to 245 days in SARS-CoV-2-negative post-COVID-19 vaccine syndrome PCVS individuals Bruce K. Patterson; Ram Yogendra; Edgar B. Francisco; Jose Guevara-Coto; Emily Long; Amruta Pise; Eric Osgood; John Bream; Mark Kreimer; Devon Jeffers...

SARS-CoV-2 S1 protein induces IgG-mediated platelet activation and is prevented by 1.8-cineole Petry; Shoykhet; Weiser; Griesbaum; Bashiri Dezfouli; Verschoor; Wollenberg COVID-19 patients face an increased risk of thromboembolic complications, yet the exact pathophysiological role of platelets...

Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19 Felix Röttele; Andreas Zollner; Carolin Mogler; Muhammed Yuksel; Cigdem Arikan; Vivien Karl; Judith Helene Aberle; Stephan...

Expression of SARS-CoV-2 spike protein in cerebral Arteries: Implications for hemorrhagic stroke Post-mRNA vaccination Nakao Ota, Masahiko Itani, Tomohiro Aoki, Aki Sakurai, Takashi Fujisawa, Yasuaki Okada, Kosumo Noda, Yoshiki Arakawa, Sadahisa Tokuda, Rokuya Tanikawa [Line breaks added]...

Long COVID: a central role for SARS-CoV-2 spike protein in a multifaceted pathogenesis Dani Holla Abstract Globally, it is estimated that over 400 million people suffer from Long COVID, a syndrome that originates from an earlier experienced SARS-CoV-2 infection. This syndrome presents with...

Abstract COVID-19 vaccines have prevented millions of COVID-19 deaths. Yet, a small fraction of the population reports a chronic debilitating condition after COVID-19 vaccination, often referred to as post- vaccination syndrome (PVS). To explore potential pathobiological features associated with...

ACE-2-like Enzymatic Activity in COVID-19 Convalescent Patients with Persistent Pulmonary Symptoms Associated with Immunoglobulin Yufeng Song; Frances Mehl; Lyndsey M. Muehling; Glenda Canderan; Kyle Enfield; Jie Sun; Michael Yin; Sarah J. Ratcliffe; Jeffrey M Wilson; Alexandra Kadl; Judith A...

iPSC-derived human cortical organoids display profound alterations of cellular homeostasis following SARS-CoV-2 infection and Spike protein exposure Gioia Cappelletti; Lorenzo Brambilla; Sergio Strizzi; Fiona Limanaqi; Valentina Melzi; Mafalda Rizzuti; Monica Nizzardo; Irma Saulle; Daria...

Molecular and Immunological Signatures of Long COVID: Implications for Diagnosis and Personalized Treatment Strategies Jorine K.N. Hammink, Tim R. van Elst [Line breaks added] Summary The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to an emerging health challenge known as “long...

Sustained Vascular Inflammatory Effects of SARS-CoV-2 Spike Protein on Human Endothelial Cells Gultom, Mitra; Lin, Lin; Brandt, Camilla Blunk; Milusev, Anastasia; Despont, Alain; Shaw, Jane; Döring, Yvonne; Luo, Yonglun; Rieben, Robert Severe acute respiratory syndrome coronavirus 2...

Autoantibodies Targeting G-Protein-Coupled Receptors and RAS-Related Molecules in Post-Acute COVID Vaccination Syndrome: A Retrospective Case Series Study Mauro Mantovani, Paolo Bellavite, Serafino Fazio, Giuseppe Di Fede, Marco Tomasi, Daniele Belli, Elisabetta Zanolin Background/Objectives...

Long-term serum spike protein persistence but no correlation with post-COVID syndrome Annick Fehrer; Franziska Sotzny; Friederike Hoheisel; Elisa Stein; Laura Kim; Claudia Kedor; Helma Freitag; Cornelia Heindrich; Sandra Bauer; Rebekka Rust; Martina Seifert; Patricia Grabowski; Nina Babel...

Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates Thibaut Naninck; Alexandra Detrille; Steve Huvelle; Marit J. van Gils; Tatiana Geara; Quentin Pascal; Jonne Snitselaar; Laetitia Bossevot; Mariangela Cavarelli; Nathalie Bosquet; Francis...

Long COVID elevated MMP-9 and release from microglia by SARS-CoV-2 Spike protein Duraisamy Kempuraj; Irene Tsilioni; Kristina K. Aenlle; Nancy G. Klimas; Theoharis C. Theoharides OBJECTIVES Long COVID is a major health concern because many patients develop chronic neuropsychiatric symptoms, but...

Abstract Evidence linking the endothelium to cardiac injury in long coronavirus disease (COVID) is well documented, but the underlying mechanisms remain unknown. Here we show that cytokines released by endothelial cells (ECs) contribute to long-COVID-associated cardiac dysfunction. Using...

Inhibition of HIF-2α Pathway as a Potential Therapeutic Strategy for Endothelial Dysfunction in Post-COVID Syndrome Andrea Ribeiro; Timon Kuchler; Maciej Lech; Javier Carbajo-Lozoya; Kristina Adorjan; Hans Christian Stubbe; Martina Seifert; Anna Wöhnle; Veronika Kesseler; Johanna Negele; Uwe...

Abstract Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19 and are persistent in patients with long COVID experiencing post-acute sequelae of SARS-CoV-2 infection1,2,3,4. Despite the clinical evidence1,5,6,7, the underlying mechanisms of coagulopathy in...

Abstract SARS-CoV-2 spike protein (SARS-2-S) induced cell–cell fusion in uninfected cells may occur in long COVID-19 syndrome, as circulating SARS-2-S or extracellular vesicles containing SARS-2-S (S-EVs) were found to be prevalent in post-acute sequelae of COVID-19 (PASC) for up to 12 months...

SARS-CoV-2 S1 subunit produces a protracted priming of the neuroinflammatory, physiological, and behavioral responses to a remote immune challenge: A role for corticosteroids Frank; Ball; Hopkins; Kelley; Kuzma; Thompson; Fleshner; Maier Long COVID is a major public health consequence of...

Abstract SARS-CoV-2-contributes to sickness and death in COVID-19 patients partly by inducing a hyper-proinflammatory immune response in the host airway. This hyper-proinflammatory state involves activation of signaling by NFκB, and unexpectedly, ENaC, the epithelial sodium channel...