spike protein

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    CROI - Conference on Retroviruses and Opportunistic Infections

    CROI - Conference on Retroviruses and Opportunistic Infections At this years CROI conference there were some presentations on Long-COVID (videos can be found at https://www.croiwebcasts.org/portal/ by using search terms such as "Long-Covid" or "post-acute"). There were also presentations of...
  2. SNT Gatchaman

    Mast cell activation triggered by SARS-CoV-2 causes inflammation in brain microvascular endothelial cells and microglia, 2024, Wu et al.

    Mast cell activation triggered by SARS-CoV-2 causes inflammation in brain microvascular endothelial cells and microglia Wu, Meng-Li; Xie, Chengzuo; Li, Xin; Sun, Jing; Zhao, Jincun; Wang, Jian-Hua SARS-CoV-2-induced excessive inflammation in brain leads to damage of blood-brain barrier...
  3. SNT Gatchaman

    The S1 subunits of SARS variants differentially trigger IL-6 signaling in brain endothelial cells and impact on microglia activation, 2024, Stangis+

    The S1 subunits of SARS-CoV-2 variants differentially trigger the IL-6 signaling pathway in human brain endothelial cells and downstream impact on microglia activation Michael Stangis; Daniel Adesse; Bhavya Sharma; Eduardo Castro; Kush Kumar; Neil Kumar; Masha Minevich; Michal Toborek...
    • SNT Gatchaman
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    • blood brain barrier brain covid endothelial cells microglia microglial activation neurovascular unit sars-cov-2 spike protein stat
    • Replies: 0
    • Forum: Long Covid research
  4. SNT Gatchaman

    Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment, 2024, Greene et al

    Preprint Blood-brain barrier disruption in Long COVID-associated cognitive impairment Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O'Keeffe, Lilia Zaporojan, Emma Connolly, Cliona Ni Cheallaigh, Niall Conlon, Colin Doherty, Matthew Campbell Vascular disruption has been...
    • SNT Gatchaman
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    • blood brain barrier brain imaging coagulation csf dce-mri endothelial gfap icam-1 inflammation long covid long covid clinic mri p-selectin pf4 platelets s100 scam-1 spike protein t cells tgf-beta tnf
    • Replies: 44
    • Forum: Long Covid research
  5. SNT Gatchaman

    SARS-CoV-2 Spike Protein Downregulates Cell Surface α7nAChR through a Helical Motif in the Spike Neck, 2023, Tillman et al.

    SARS-CoV-2 Spike Protein Downregulates Cell Surface α7nAChR through a Helical Motif in the Spike Neck Tommy S. Tillman; Qiang Chen; Vasyl Bondarenko; Jonathan A. Coleman; Yan Xu; Pei Tang A deficiency of the functional α7 nicotinic acetylcholine receptor (α7nAChR) impairs neuronal and immune...
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    Prevalent and persistent new-onset autoantibodies in mild to severe COVID-19, 2024, Nilsson et al

    Now published - link here Preprint Prevalent and persistent new-onset autoantibodies in mild to severe COVID-19 Abstract Autoantibodies have been shown to be implied in COVID-19 but the emerging autoantibody repertoire remains largely unexplored. We investigated the new-onset autoantibody...
    • EndME
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    • autoantibodies ccdc63 interferon snurf spike protein trim63
    • Replies: 9
    • Forum: Long Covid research
  7. SNT Gatchaman

    The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics, 2023, Pileggi et al.

    The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics Pileggi; Parmar; Elkhatib; Stewart; Alecu; Côté; Bennett; Sandhu; Cuperlovic-Culf; Harper SARS-CoV-2 infection is associated with both acute and post-acute neurological symptoms. Emerging evidence...
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    • autophagy mitochondria mitophagy monoamine oxidase neurodegenerative disease parkinsons sars-cov-2 spike protein
    • Replies: 18
    • Forum: Long Covid research
  8. SNT Gatchaman

    Preprint Plasma-based antigen persistence in the post-acute phase of SARS-CoV-2 infection, 2023, Peluso, Swank et al.

    Plasma-based antigen persistence in the post-acute phase of SARS-CoV-2 infection Michael J. Peluso; Zoe N. Swank; Sarah A. Goldberg; Scott Lu; Thomas Dalhuisen; Ella Borberg; Yasmeen Senussi; Michael A. Luna; Celina Chang Song; Alexus Clark; Andhy Zamora; Megan Lew; Badri Viswanathan; Beatrice...
  9. SNT Gatchaman

    Analysis of the Tropism of SARS-CoV-2 Based on the Host Interactome of the Spike Protein, 2023, Bamberger et al.

    Analysis of the Tropism of SARS-CoV-2 Based on the Host Interactome of the Spike Protein Casimir Bamberger; Sandra Pankow; Salvador Martínez-Bartolomé; Jolene K. Diedrich; Robin S. K. Park; John R. Yates, III The β-coronavirus SARS-CoV-2 causes severe acute respiratory syndrome (COVID-19) in...
  10. SNT Gatchaman

    SARS-CoV-2 Spike Protein S1 Domain Accelerates α-Synuclein Phosphorylation and Aggregation in Cellular Models of Synucleinopathy, 2023, Wang et al.

    SARS-CoV-2 Spike Protein S1 Domain Accelerates α-Synuclein Phosphorylation and Aggregation in Cellular Models of Synucleinopathy Wang, Jiannan; Dai, Lijun; Deng, Min; Xiao, Tingting; Zhang, Zhaohui; Zhang, Zhentao The 2019 novel coronavirus disease (COVID-19) is an infectious disease that began...
  11. SNT Gatchaman

    Near-Infrared Light Exposure Triggers ROS to Downregulate Inflammatory Cytokines Induced by SARS Spike Protein in Human Cell Culture, 2023, Aguida +

    Near-Infrared Light Exposure Triggers ROS to Downregulate Inflammatory Cytokines Induced by SARS-CoV-2 Spike Protein in Human Cell Culture Aguida, Blanche; Chabi, Marie-Marthe; Baouz, Soria; Mould, Rhys; Bell, Jimmy D.; Pooam, Marootpong; André, Sebastien; Archambault, Dominique; Ahmad...
  12. SNT Gatchaman

    Preliminary Evidence of the Differential Expression of HERVs in Kawasaki Disease and SARS-CoV-2-Associated MIS-C, 2023, Balestrieri et al.

    Preliminary Evidence of the Differential Expression of Human Endogenous Retroviruses in Kawasaki Disease and SARS-CoV-2-Associated Multisystem Inflammatory Syndrome in Children Balestrieri, Emanuela; Corinaldesi, Elena; Fabi, Marianna; Cipriani, Chiara; Giudice, Martina; Conti, Allegra...
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    • children herv herv-k herv-w il-6 kawasaki mis-c nf-κb retrovirus sars-cov-2 spike protein syncitin tlr-4
    • Replies: 0
    • Forum: Long Covid research
  13. SNT Gatchaman

    Review Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19, 2023, Nair et al.

    Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19 Nair, Soumyalekshmi; Nova-Lamperti, Estefania; Labarca, Gonzalo; Kulasinghe, Arutha; Short, Kirsty R.; Carrión, Flavio; Salomon, Carlos COVID-19 continues to affect an unprecedented number...
    • SNT Gatchaman
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    • epigenetics extracellular vesicles gene expression glucose innate immune system lipid metabolism long covid metabolism sars-cov-2 spike protein thrombosis
    • Replies: 0
    • Forum: Long Covid research
  14. SNT Gatchaman

    SARS-CoV-2 spike antigen-specific B cell and antibody responses in convalescent males and females with or without post-covid condition, 2023, Limoges+

    SARS-CoV-2 spike antigen-specific B cell and antibody responses in pre-vaccination period COVID-19 convalescent males and females with or without post-covid condition Limoges, Marc-André; Quenum, Akouavi Julite Irmine; Chowdhury, Mohammad Mobarak Hussain; Rexhepi, Fjolla; Namvarpour, Mozhdeh...
    • SNT Gatchaman
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    • b cells dysregulation humoral immune response innate immune response long covid sex differences spike protein t cells viral persistence
    • Replies: 2
    • Forum: Long Covid research
  15. SNT Gatchaman

    Vaccination after developing long COVID: impact on clinical presentation, viral persistence and immune responses, 2023, Nayyerabadi et al.

    Vaccination after developing long COVID: impact on clinical presentation, viral persistence and immune responses Maryam Nayyerabadi; Lyvia Fourcade; Swarali A. Joshi; Prabha Chandrasekaran; Arpita Chakravarti; Chantal Massé; Marie-Lorna Paul; Joanie Houle; Amina M. Boubekeur; Charlotte DuSablon...
  16. SNT Gatchaman

    [Preprint] Identification of a Druggable Site on GRP78 at the GRP78-SARS-CoV-2 Interface and Compounds to Disrupt that Interface, 2023, Lazou et al.

    Identification of a Druggable Site on GRP78 at the GRP78-SARS-CoV-2 Interface and Compounds to Disrupt that Interface Maria Lazou; Jonathan R. Hutton; Arijit Chakravarty; Diane Joseph-McCarthy SARS-CoV-2, the virus that causes COVID-19, led to a global health emergency that claimed the lives of...
  17. SNT Gatchaman

    SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication, 2023, Montezano et al.

    SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication Montezano, Augusto C.; Camargo, Livia L.; Mary, Sheon; Neves, Karla B; Rios, Francisco J; Stein, Ross; Lopes, Rheure A.; Beattie, Wendy; Thomson, Jacqueline; Herder, Vanessa; Szemiel, Agnieszka...
  18. SNT Gatchaman

    Are the integrin binding motifs within SARS CoV-2 spike protein and MHC class II alleles playing the key role in COVID-19?, 2023, Gerencer & McGuffin

    Are the integrin binding motifs within SARS CoV-2 spike protein and MHC class II alleles playing the key role in COVID-19? Gerencer, Marijan; McGuffin, Liam J. The previous studies on the RGD motif (aa403-405) within the SARS CoV-2 spike (S) protein receptor binding domain (RBD) suggest that...
  19. SNT Gatchaman

    SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular Ca homeostasis & impairs pulmonary vascular endothelial cells, 2023, Yang+

    SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells Yang, Kai; Liu, Shiyun; Yan, Han; Lu, Wenju; Shan, Xiaoqian; Chen, Haixia; Bao, Changlei; Feng, Huazhuo; Liao, Jing; Liang, Shuxin; Xu, Lei; Tang...
    • SNT Gatchaman
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    • calcium channels covid endothelial endothelial cells lungs microvascular sars-cov-2 spike protein vascular
    • Replies: 3
    • Forum: Long Covid research
  20. SNT Gatchaman

    SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling, 2023 Perico+

    SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling Perico, Luca; Morigi, Marina; Pezzotta, Anna; Locatelli, Monica; Imberti, Barbara; Corna, Daniela; Cerullo, Domenico; Benigni, Ariela; Remuzzi, Giuseppe The...
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