spike protein

SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling Perico, Luca; Morigi, Marina; Pezzotta, Anna; Locatelli, Monica; Imberti, Barbara; Corna, Daniela; Cerullo, Domenico; Benigni, Ariela; Remuzzi, Giuseppe The...

SARS-COV-2 spike protein fragment eases amyloidogenesis of α-synuclein Chesney, Andrew D.; Maiti, Buddhadev; Hansmann, Ulrich H. E. Parkinson’s Disease is accompanied by presence of amyloids in the brain formed of α-synuclein chains. Correlation between COVID-19 and the onset of Parkinson’s...

Cellular microRNAs target SARS-CoV-2 spike protein and restrict viral replication Kishore Vaddadi ; Chaitanya Gandikota ; Chaoqun Huang ; Yurong Liang ; Lin Liu MicroRNAs (miRNAs) regulate gene expression post-transcriptionally and are implicated in viral replication and host tropism...

High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner Correa; Del Giudice; Waldie; Thépaut; Micciula; Gerelli; Moulin; Delaunay; Fieschi; Pichler; Haertlein; Forsyth; Le Brun; Moir; Russell; Darwish; Brinck; Wodaje; Jansen; Martín...

Molecular Analysis of SARS-CoV-2 Spike Protein-Induced Endothelial Cell Permeability and vWF Secretion Guo, Yuexi; Kanamarlapudi, Venkateswarlu Coronavirus disease COVID-19, which is caused by severe acute respiratory syndrome coronavirus SARS-CoV-2, has become a worldwide pandemic in recent...

Spike Protein Impairs Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying Cardiac Injury in COVID-19 Huynh, Tin Van; Rethi, Lekha; Lee, Ting-Wei; Higa, Satoshi; Kao, Yu-Hsun; Chen, Yi-Jen Background: COVID-19 has a major impact on cardiovascular diseases and may lead to...

Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis Lael M. Yonker; Zoe Swank; Yannic C. Bartsch; Madeleine D. Burns; Abigail Kane; Brittany P. Boribong; Jameson P. Davis; Maggie Loiselle; Tanya Novak; Yasmeen Senussi; Chi-An Cheng; Eleanor Burgess; Andrea G. Edlow...

SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 Zhouyi Rong; Hongcheng Mai; Saketh Kapoor; Victor Puelles; Jan Czogalla; Julia Schaedler; Jessica Vering; Claire Delbridge; Hanno Steinke...

Murine Alveolar Macrophages Rapidly Accumulate Intranasally Administered SARS-CoV-2 Spike Protein leading to Neutrophil Recruitment and Damage Chung Park, Il-Young Hwang, Serena Li-Sue Yan, Sinmanus Vimonpatranon, Danlan Wei, Don Van Ryk, Claudia Cicala, James Arthos, John H Kehrl (National...

Determination of IgG1 and IgG3 SARS-CoV-2 Spike Protein and Nucleocapsid Binding-Who Is Binding Who and Why? Iles JK, Zmuidinaite R, Sadee C, Gardiner A, Lacey J, Harding S, Wallis G, Patel R, Roblett D, Heeney J, Baxendale H, Iles RK The involvement of immunoglobulin (Ig) G3 in the humoral...

SARS-CoV-2 Spike Protein Binding of Glycated Serum Albumin-Its Potential Role in the Pathogenesis of the COVID-19 Clinical Syndromes and Bias towards Individuals with Pre-Diabetes/Type 2 Diabetes and Metabolic Diseases Iles J, Zmuidinaite R, Sadee C, Gardiner A, Lacey J, Harding S, Ule J...

Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity Briquez PS, Rouhani SJ, Yu J, Pyzer AR, Trujillo J, Dugan HL, Stamper CT, Changrob S, Sperling AI, Wilson PC, Gajewski TF, Hubbell JA, Swartz MA Patients infected...

A Case Report: Multifocal Necrotizing Encephalitis and Myocarditis after BNT162b2 mRNA Vaccination against COVID-19 Michael Mörz The current report presents the case of a 76-year-old man with Parkinson’s disease (PD) who died three weeks after receiving his third COVID-19 vaccination. The...

SARS-CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4 (CKAP4) Kan Li, Liu Yao, Jin Wang, Hao Song, Yan-hong Zhang, Xue Bai, Kai Zhang, Dong-ming Zhou, Ding Ai, Yi Zhu Letter to Nature: Signal Transduction and Targeted Therapy Link | PDF

Liquid biomarkers of macrophage dysregulation and circulating spike protein illustrate the biological heterogeneity in patients with post-acute sequelae of COVID-19 Christoph Schultheiss, Edith Willscher, Lisa Paschold, Cornelia Gottschick, Bianca Klee, Lidia Bosurgi, Jochen Dutzmann, Daniel...

Abstract The pathophysiology of COVID-19-associated coagulopathy is complex and not fully understood. SARS-CoV-2 spike protein (SP) may activate platelets and interact with fibrin(ogen). We aimed to investigate whether isolated SP can be present in clots retrieved in COVID-19 patients with...

Persistent Presence of Spike protein and Viral RNA in the Circulation of Individuals with Post-Acute Sequelae of COVID-19 Vaughn Craddock, Aatish Mahajan, Balaji Krishnamachary, Leslie Spikes, PrabhakarChalise, Navneet Kaur Dhillon SARS-CoV-2, the causative agent of COVID-19 disease has...

Mitochondrial Dysfunction: A Prelude to Neuropathogenesis of SARS-CoV‐2 Artem Pliss, Andrey N. Kuzmin, Paras N. Prasad, Supriya D. Mahajan The SARS-CoV-2 virus is notorious for its neuroinvasive capability, causing multiple neurological conditions. The neuropathology of SARS-CoV-2 is...

Background We sought to determine the immunologic abnormalities in patients following SARS-CoV-2 vaccines who experience post-acute sequelae of COVID-19 (PASC)-like symptoms > 4 weeks post vaccination. In addition, we investigated whether the potential etiology was similar to PASC. Design: We...

Amyloidogenesis of SARS-CoV-2 Spike Protein Sofie Nyström, Per Hammarström Abstract SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and...