study idea

Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome Katherine A. Glass, Ludovic Giloteaux, Sheng Zhang, Maureen R. Hanson [Line...

Multicentre retrospective detection of nailfold videocapillaroscopy abnormalities in long covid patients Lia Ginaldi; Giovanna Cuomo; Study Group on Capillaroscopy and Microcirculation in Rheumatic Diseases of the Italian Society of Rheumatology (Capsir); Emanuele Gotelli; Rosanna Campitiello...

We do a number of studies on blood samples, we capture plasma and PBMCs, sometimes we captures serum and RBCs. What type of markers do you guys think should be looked at? Or what type of assays should be performed on these biomarkers? You can even suggest combinations. Specific names should be...

See post #5 for published version https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1443363/abstract Front. Immunol. Sec. Viral Immunology Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1443363 This article is part of the Research TopicImmunological consequences of viral...

Published Link here: Cardiac Output–Cerebral Blood Flow Relationship Is Abnormal in Most ME/CFS Patients with a Normal Heart Rate & Blood Pressure ..., 2024, van Campen Preprint Full title: The cardiac output - cerebral blood flow relation is abnormal in most ME/CFS patients with a normal heart...

Oculomotor Behaviour in Individuals with Long COVID-19 L González-Vides; JL Hernández-Verdejo; JA Gómez-Pedrero; A Ruiz-Pomeda; P Cañadas-Suárez OBJECTIVES To determine, the impact of long COVID-19 on oculomotor behaviour. DESIGN A case–control study. SETTING Spanish Association of Persistent...

Abstract Gulf War Illness (GWI) is a chronic condition characterized by multisystem symptoms that still affect up to one-third of veterans who engaged in combat in the Gulf War three decades ago. The aetiology of GWI is mainly explained by exposure to multiple toxic agents, vaccines, and...

Abstract Orthostatic hypotension (OH) is prevalent in older adults and can cause falls and hospitalization. Diagnostic intermittent blood pressure (BP) measurements are only a proxy for cerebral perfusion and do not reflect daily-life BP fluctuations. Near-infrared spectroscopy (NIRS)-measured...

https://www.neurology.org/doi/10.1212/WNL.0000000000205761 GENERAL NEUROLOGY: NEUROIMMUNOLOGY April 9, 2024 Free Access Low Vasopressin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (P4-4.006) Helena Huhmar, Lauri Soinne, Per Sjögren, Bo Christer Bertilson, Per Hamid Ghatan, Björn...

This may be done elsewhere on the site, but I thought it would be interesting to see what research patients would like to see. Perhaps if there is enough then we could do some sort of briefing paper with ideas for Chris Ponting.

Role of the complement system in Long COVID Vadim Farztdinov; Boris Zuehlke; Franziska Sotzny; Fridolin Steinbeis; Martina Seifert; Claudia Kedor; Kirsten Wittke; Pinkus Tober-Lau; Kathrin Textoris-Taube; Daniela Ludwig; Clemens Dierks; Dominik Bierbaum; Leif Erik Sander; Leif Gunnar Hanitsch...

Full title: Comparison of the muscle oxygenation during submaximal and maximal exercise tests in patients post-coronavirus disease 2019 syndrome with pulmonary involvement ABSTRACT Introduction Pulmonary involvement is prevalent in patients with coronavirus disease 2019 (COVID-19). Arterial...

https://onlinelibrary.wiley.com/doi/full/10.1002/adsr.202300178 A Novel Fluorogenic Probe Reveals Lipid Droplet Dynamics in ME/CFS Fibroblasts Siyang Ding, Oana Sanislav, Daniel Missailidis, Claire Yvonne Allan, Tze Cin Owyong, Ming-Yu Wu, Sijie Chen, Paul Robert Fisher, Sarah Jane Annesley...

Impaired oxygen delivery to muscle in chronic fatigue syndrome McCully, Kevin K.; Natelson, Benjamin H. The purpose of this study was to determine if chronic fatigue syndrome (CFS) is associated with reduced oxygen delivery to muscles. Patients with CFS according to CDC (Center for Disease...

Structural and functional impairments of skeletal muscle in patients with post-acute sequelae of SARS-CoV-2 infection Marta Colosio ; Lorenza Brocca ; Marco Gatti ; Marianna Neri ; Emanuela Crea ; Francesca Cadile ; Monica Canepari ; Maria Antonietta Pellegrino ; Biagio Polla ; Simone...

The pre-publication thread has been merged with the thread on the paper. Link to paper's abstract here...

Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology Eva K Hejbøl, Thomas Harbo, Jane Agergaard, Line B Madsen, Thomas H Pedersen, Lars J Østergaard, Henning Andersen, Henrik D Schrøder, Hatice Tankisi Background: Among post-COVID-19...

Preprint Medrix Dynamic Epigenetic Changes during a Relapse and Recovery Cycle in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Helliwell A.M., Stockwell P.A., Edgar C.D., Chatterjee A., & Tate W.P. Abstract (242) Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700209/#B47-biomedicines-08-00523 Abstract Blood neurofilament light chain (NfL) is a marker of neuro-axonal injury showing promising associations with outcomes of interest in several neurological conditions. Although initially discovered and...