synapse

Systems neuroendocrinology in ME/CFS and long COVID: a chronobiological framework for hormone-based research Hormonal dysregulation is increasingly reported in ME/CFS and Long COVID, yet the broader role of neuroendocrine disruption in these conditions remains underexplored. While changes in...

Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry Anxiety is heritable and exists on a continuum, with symptoms ranging from adaptive threat response to clinical disorder. Here we performed a genome-wide association...

Wake-active brainstem GABA neurons signal sleep pressure by upregulating AMPA receptors to drive recovery sleep How the brain compensates for sleep deprivation (SD) by generating recovery sleep (RS) is not understood. Using Ca²⁺ photometry, we identified a WAKE/rapid eye movement sleep...

Integrity of Presynaptic Neurons in Long COVID and Relationship to Neuropsychiatric Symptoms Yuhan Liu, Devina Persaud, Erica Vieira, Joeffre Braga, Pablo Rusjan, Laura Miler, Jennifer Rabin, Tina Mccluskey, Isabelle Boileau, Thomas Chao, Michael Bagby, Lucas Narciso, Lauren Gray, Neil Vasdev...

Systems-level transcriptomic analysis reveals synapse-related gene dysregulation in peripheral leukocytes of MDD patients Major depressive disorder (MDD) involves both central nervous system dysfunction and systemic immune alterations. Using a systems biology approach, we investigated whether...

Hidden in the white matter: Current views on interstitial white matter neurons Maximilian Fischer; Maria Kukley The mammalian brain comprises two structurally and functionally distinct compartments: the gray matter (GM) and the white matter (WM). In humans, the WM constitutes approximately half...

Biological Insights from Genome-Wide Association Studies and Whole Genome Sequencing of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Maccallini, Paolo Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disorder of poorly understood etiology. We...

Neuronal ARHGAP8 controls synapse structure and AMPA receptor-mediated synaptic transmission The aberrant formation and function of neuronal synapses are recognized as major phenotypes in many cases of neurodevelopmental (NDDs) and -psychiatric disorders (NPDs). A growing body of research has...

Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity Trafficking and biophysical properties of AMPA receptors (AMPARs) in the brain depend on interactions with associated proteins. We identify Shisa6, a single transmembrane protein, as a...

The locus near SHISA6 wasn't quite genome-wide significant, but it was close at p=8.26e-08. From GeneCards: Here is a plot of this locus (LocusZoom link): Edit: The lead variant at this locus is: 17:11,325,637:G:C / rs1546559

Abstract Background Cognitive dysfunction (“brain fog”), encompassing impairments in attention, processing speed, memory, and executive function, is a prevalent and disabling feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). While systemic immune abnormalities are well...

Genome-wide DNA methylation profiling in COVID-19 positive patients reveals alterations in pathways linked to neurological dysfunction BACKGROUND Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible RNA betacoronavirus, causing coronavirus disease-19...

Brain-Liquid biopsy and extracellular vesicles: Toward neuroimmune and neurovascular precision in psychosis spectrum disorders Altunsu; Lizano No abstract. Web | DOI | Brain, Behavior, and Immunity | Paywall

Developmental convergence and divergence in human stem cell models of autism Two decades of genetic studies in autism spectrum disorder (ASD) have identified more than 100 genes harbouring rare risk mutations1,2,3,4,5,6,7,8,9,10,11,12,13. Despite this substantial heterogeneity, transcriptomic...

Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease The immunological synapse (IS) serves as the fundamental architectural framework for direct interactions and secretory crosstalk between immune cells, as well as between immune cells and other...

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender Excessive exercise impairs cognitive function, but the underlying mechanism remains unclear. Here, we show that excessive vigorous exercise-induced lactate accumulation stimulates muscles to...

Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19 Abstract Although brain alterations have been reported in post-acute sequelae of SARS-CoV-2 (PASC), their prevalence and relationship to neurodegeneration remain...

Dynamic extracellular interactions with AMPA receptors Synaptic plasticity in the central nervous system enables the encoding, storing, and integrating new information. AMPA (alpha-amino-3-hydroxyl-5-methyl-isoxazole-4-propionic acid)-type glutamate receptors (AMPARs) are ligand-gated ion...

A Role for the Ubiquitin–Proteasome System in Activity-Dependent Presynaptic Silencing Jiang, Xiaoping; Litkowski, Patricia E.; Taylor, Amanda A.; Lin, Ying; Snider, B. Joy; Moulder, Krista L. Abstract Chronic changes in electrical excitability profoundly affect synaptic transmission...

The proteasome: A key modulator of nervous system function, brain aging, and neurodegenerative disease Davidson, K., & Pickering, A. M. Abstract The proteasome is a large multi-subunit protease responsible for the degradation and removal of oxidized, misfolded, and polyubiquitinated proteins...