t cells

  1. Mij

    Magnesium sensing via LFA-1 regulates CD8+ T cell effector function, 2022, Jonas Lotscher et al

    Highlights: • LFA-1 mediated co-stimulation of CD8+ T cells depends on extracellular magnesium • Magnesium is sensed via LFA-1 and regulates the effector function of CD8+ T cells • Low serum magnesium levels are associated with worse outcomes in cancer immunotherapy • The magnesium-LFA-1...
  2. Sean

    Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2, 2021, Leo Swadling et al

    Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 Leo Swadling, et al. Individuals with potential exposure to SARS-CoV-2 do not necessarily develop PCR or antibody positivity, suggesting some may clear sub-clinical infection before seroconversion. T-cells...
  3. leokitten

    Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19, 2021, Lee et al

    Pure speculation but maybe this line of research or the methods used in the paper to understand immune cell metabolic reprogramming via single-cell multiomics could eventually help explain whatever possible cellular metabolic changes that are triggered and persist in Long COVID and ME/CFS…...
  4. J

    Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning Patterson et al. 2021

    https://www.frontiersin.org/articles/10.3389/fimmu.2021.700782/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE Expression of CCR5 and its cognate ligands have been implicated in COVID-19 pathogenesis, consequently therapeutics directed against CCR5 are being...
    • Jaybee00
    • Thread
    • bruce patterson ifny il-2 immunology interferon long covid post covid-19 syndrome t cells vegf
    • Replies: 2
    • Forum: ME/CFS research
  5. Andy

    Long-COVID following mild SARS CoV-2 infection: characteristic T cell alterations and response to antihistamines, 2021, Glynne et al

    Preprint Abstract Background: Long-COVID is characterised by the emergence of multiple debilitating symptoms following SARS CoV2 infection. Its aetiology is unclear, and it often follows a mild acute illness. Anecdotal reports of gradual clinical responses to histamine receptor antagonists...
  6. Marky

    The possibility of autoimmunity or auto-reactivity in ME/CFS

    This thread was split from Open Medicine Foundation (OMF) News I thought we could not conclude autoimmunity is likely out of the picture as long as we dont know how to target long lived plasma cells? I mean b-cells dont really matter at that point if im not mistanken, as the autoimmune plasma...
  7. Andy

    Brain astrocytes & microglia express functional MR1 molecules that present microbial antigens to ... (MAIT) cells, 2020, Priya et al

    Full title: Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells Paywall, https://www.jni-journal.com/article/S0165-5728(20)30689-5/fulltext Sci hub, https://sci-hub.se/10.1016/j.jneuroim.2020.577428
  8. Andy

    Immunometabolic profiling of T cells from .. relapsing-remitting [MS] .. impairment in glycolysis and mitochondrial respiration, 2017, Matarese et al

    Full title: Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and mitochondrial respiration Open access, https://www.metabolismjournal.com/article/S0026-0495(17)30217-2/fulltext
  9. Andy

    Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells, 2020, Campbell et al

    Paywall, https://www.nature.com/articles/s41586-020-2193-0 Sci hub, https://sci-hub.tw/10.1038/s41586-020-2193-0
  10. R

    Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset (2020) Scheibenbogen et al.

    https://www.frontiersin.org/articles/10.3389/fimmu.2020.00578/full Excerpt: In conclusion, our study shows that the PTPN22 rs2476601 and CTLA4 rs3087243 autoimmunity risk variants are more frequent in patients with ITO ME/CFS. This finding provides further evidence that there is a genetic...
    • Ron
    • Thread
    • 2020 autoimmunity b cells genetics me/cfs paper pathogenesis scheibenbogen steiner t cells
    • Replies: 10
    • Forum: ME/CFS research
  11. Dolphin

    Role of immune responses, focussing on herpes virus specificity and interferon-gamma, in Myocardial Infarction with reperfusion & in CFS, 2019, Murali

    • Dolphin
    • Thread
    • 2019 cmv cytokines ebv herpesvirus me/cfs murali myocardial paper t cells
    • Replies: 0
    • Forum: ME/CFS research
  12. Sly Saint

    BIOMARKER FOR MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (ME/CFS) - Yamamoto et al 27 Feb 2020

    https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020040210&tab=PCTBIBLIO (main paper in japanese)
    • Sly Saint
    • Thread
    • 2020 b cells biomarker iggr me/cfs paper t cells yamamoto
    • Replies: 6
    • Forum: ME/CFS research
  13. Andy

    T cell immunomodulation by bile acid metabolites, 2020, Giovannini et al

    A short review/opinion piece. Paywall, https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.14223 Sci hub, https://sci-hub.se/10.1111/all.14223 @mariovitali , another one that will probably interest you. :)
  14. Sly Saint

    Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations - [new article 2020]

    Basal glycolysis is reduced in ME/CFS CD4+ T cells. https://www.jci.org/articles/view/132185/figure/4 paper from December 2019 https://www.jci.org/articles/view/132185 new Article by Mady Hornig https://www.jci.org/articles/view/134985
    • Sly Saint
    • Thread
    • 2020 article cytokines glycolysis hornig me/cfs metabolism paper t cells
    • Replies: 5
    • Forum: ME/CFS research
  15. Andy

    Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis, 2019, Song et al

    In mice. Paywall, https://www.nature.com/articles/s41586-019-1865-0 Sci hub, https://sci-hub.se/10.1038/s41586-019-1865-0 ETA: Added "In mice".
  16. Andy

    Bile acid metabolites control TH17 and Treg cell differentiation, 2019, Hang et al

    In mice. Paywall, https://www.nature.com/articles/s41586-019-1785-z Sci hub, https://sci-hub.se/10.1038/s41586-019-1785-z
  17. Hoopoe

    Perturbation of effector and regulatory T cell subsets in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (2019) Karhan, Unutmaz et al

    Moderator note: See this post in the thread for the preprint.
    • Hoopoe
    • Thread
    • 2019 biomarker intestinal permeability jackson labs leaky gut mait cells me/cfs microbiome paper t cells unutmaz zonulin
    • Replies: 90
    • Forum: ME/CFS research
  18. Sly Saint

    ME/CFS Research Update: November 2019 Bedside Chat with Ben H. and Ron Davis

    thanks to @Ben H eta: youtube generated transcript pt 1
    • Sly Saint
    • Thread
    • 2019 cci clonal expansion me/cfs omf red blood cell deformability research ron davis t cells trypanosome video
    • Replies: 2
    • Forum: ME/CFS research
  19. Cheshire

    Cellular immune function in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) (2019) Cliff, Nacul et al.

    https://www.frontiersin.org/articles/10.3389/fimmu.2019.00796/abstract Full, open access, text here, https://www.frontiersin.org/articles/10.3389/fimmu.2019.00796/full ETA: Link to full text.
    • Cheshire
    • Thread
    • immunology me/cfs monocytes nacul natural killer cells t cells temra
    • Replies: 18
    • Forum: ME/CFS research
  20. Andy

    Mitochondrial complex III is essential for suppressive function of regulatory T cells, 2019, Chandel et al

    Open access (PDF file) at https://www.nature.com/articles/s41586-018-0846-z.epdf?shared_access_token=WAkCBVS3L3DO0bM6CbjKJ9RgN0jAjWel9jnR3ZoTv0NUSr5JeVHn5ILb4ngHL_BsTJMx2GJRjntjSBzshFZ8yE4tC3l6CzSLy6_zVux-gc6CNyCRZyfQaZAXy__EeJqkVjgWHo5q5hftEAvdjdhYIjKN3PqYRuicN1bmJ64vvgs%3D
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