t-cells

I don't know if this has been posted elsewhere but I thought it was very interesting. I wonder if something like this might end up being helpful for a subset of pwME... https://www.theguardian.com/science/2022/sep/15/scientists-hail-autoimmune-disease-therapy-breakthrough-car-t-cell-lupus "In...

https://www.nature.com/articles/s41586-022-05105-1 Abstract CD8+ T cells that respond to chronic viral infections or cancer are characterized by the expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by the impaired production of cytokines. This state of...

Abstract The gut microbiota encodes a broad range of enzymes capable of synthetizing various metabolites, some of which are still uncharacterized. One well-known class of microbiota-derived metabolites are the short-chain fatty acids (SCFAs) such as acetate, propionate, butyrate and valerate...

https://www.nature.com/articles/s41586-022-05128-8

From: Dr. Marc-Alexander Fluks Source: University of Leeds Date: May 2020, online January 11, 2022 URL: https://etheses.whiterose.ac.uk/28168/ https://etheses.whiterose.ac.uk/28168/1/Final%20and%20corrected%20MD%20C.Strachan.pdf A flow cytometric analysis of B and T-lymphocyte...

Full title: EBV/HHV-6A dUTPases contribute to Myalgic Encephalomyelitis/Chronic-Fatigue-Syndrome pathophysiology by enhancing TFH cell differentiation and extrafollicular activities Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, debilitating multisystem illness of...

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 Leo Swadling, et al. Individuals with potential exposure to SARS-CoV-2 do not necessarily develop PCR or antibody positivity, suggesting some may clear sub-clinical infection before seroconversion. T-cells...

From: Dr. Marc-Alexander Fluks Source: University of Oslo Date: May 18 and June 21, 2021 URL: https://www.duo.uio.no/bitstream/handle/10852/87105/7/Ueland_MasterThesis_2021.pdf Ref: https://www.mn.uio.no/ibv/studier/aktuelt/mastereksamen/var-2021/marthe%20ueland.html Genetic study of...

Full title: Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci Abstract The etiology of myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is unknown, but...

Highlights The magnitude of early CD4+ T cell responses correlates with severity of COVID-19 Prior lung disease correlates with higher SARS-CoV-2-specific CD8+ T cell responses PASC is associated with a decline in N-specific interferon-γ-producing CD8+ T cells Neutralizing capacity correlates...

Now published, see post #21. https://www.biorxiv.org/content/10.1101/2021.06.25.449905v2 The recent COVID-19 pandemic is a treatment challenge in the acute infection stage but the recognition of chronic COVID-19 symptoms termed post-acute sequelae SARS-CoV-2 infection (PASC) may affect up to...

Full title: Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection Highlights Tpex cells preserve mitochondrial fitness during chronic infection TGF-β-mediated mTOR-inhibition preserves metabolism in Tpex...

Performed detailed molecular and spatial analysis of the COVID-19 brain immune response Pathognomonic microglial nodules and T cell infiltration are present in COVID-19 brains Altered microglia-T cell interactions correlate with systemic measures of inflammation Vascular leakage is linked with...

This post has been copied and following discussion moved from this thread: USA: NIH National Institute of Health The NIH has awarded a $2.5M R01 grant to Drs Liisa Selin and Anna Gil for their work on altered T cells in ME/CFS. This follows their 2019 Ramsay award from Solve ME with which they...

https://www.jci.org/articles/view/140491 ScienceDaily News piece on paper here Of particular interest to long COVID research is they found immune dysregulation in non-hospitalized patients didn’t resolve quickly as well as activation and exhaustion markers increased during the...

This paper on Alzheimer’s is interesting because Mark Davis (one of the authors) and team are using similar techniques on ME patients to look for targets for T-Cell expansion. For Alzheimer's they found TCR's responding to two separate Epstein–Barr virus antigens in CSF...

Note: mice. Vasanthakumar, A., Chisanga, D., Blume, J. et al. Sex-specific adipose tissue imprinting of regulatory T cells. Nature (2020). https://doi.org/10.1038/s41586-020-2040-3 https://www.nature.com/articles/s41586-020-2040-3 (paywalled) Article about paper: Sex-specific traits of the...

https://www.mdpi.com/1422-0067/21/4/1186

https://www.nature.com/articles/s41586-020-1951-3 Only in mice and monkeys but quite interesting that they are flushing out a latent virus. And great if they can use it to eliminate HIV as well, of course.

Possibly of interest, given how many patients can be on these types of drugs. Though I don't really understand what the implications might be myself without reading the full paper. https://www.sciencedirect.com/science/article/abs/pii/S0924977X1931870X