t-cells

  1. R

    ME/CFS patients exhibit altered T cell metabolism and cytokine associations (2019) Mandarano, Hanson et al

    https://www.nih.gov/news-events/news-releases/study-finds-differences-energy-use-immune-cells-me/cfs New findings published in the Journal of Clinical Investigation suggest that specific immune T cells from people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) show disruptions...
    • Ron
    • Thread
    • cornell university cytokines immune challenge immunology mandarano maureen hanson me/cfs t-cells
    • Replies: 28
    • Forum: ME/CFS research
  2. rvallee

    First evidence of immune response targeting brain cells in autism

    Preliminary but interesting. Autism has been researched far more than ME and somehow this had been missed entirely. I would really like to see research done on post-mortem ME brains and spinal cords. This is the reason the researchers named this disease and there doesn't seem to have been any...
  3. Cheshire

    ME/CFS as a hyper-regulated immune system driven by an interplay between regulatory T cells & chronic human herpesvirus infections (2019) Nacul et al.

    Nuno Sepúlveda, Jorge Carneiro, Eliana M. Lacerda and Luis C. Nacul https://www.frontiersin.org/articles/10.3389/fimmu.2019.02684/abstract Study made with the UK ME/CFS Biobank Full text not available yet, will be published soon.
    • Cheshire
    • Thread
    • 2019 ebv herpesvirus me/cfs nacul paper sepulveda t-cells
    • Replies: 32
    • Forum: ME/CFS research
  4. Dolphin

    Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis

    Somebody with ME was excited by this on Twitter https://insight.jci.org/articles/view/124714 Research ArticleClinical trialsNeuroscience Free access | 10.1172/jci.insight.124714 Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis Michael P. Pender,1,2,3 Peter A...
  5. Andy

    Associations between clinical symptoms, plasma norepinephrine & deregulated immune gene networks in subgroups of adolescent w/CFS, 2018, Nguyen et al

    Paywalled at https://www.sciencedirect.com/science/article/pii/S0889159118307967?via%3Dihub
    • Andy
    • Thread
    • 2018 genetics immunology me/cfs nguyen norepinephrine paper t-cells young people
    • Replies: 3
    • Forum: ME/CFS research
  6. Andy

    Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation, 2018, Unutmaz et al

    Paywalled at https://www.nature.com/articles/s41385-018-0072-x While this is in "Unrelated to ME/CFS research" forum, the blog below, from Jackson Labs, suggests that it could have some implication in ME. https://jaxmecfs.com/2018/09/24/750/
  7. M

    Functional Interrogation of Primary Human T Cells via CRISPR Genetic Editing (2018)

    Functional Interrogation of Primary Human T Cells via CRISPR Genetic Editing Dr Unutmaz is one of the principal investigator of this paper. http://www.jimmunol.org/content/early/2018/07/18/jimmunol.1701616?papetoc Abstract: Abstract Developing precise and efficient gene editing approaches...
  8. Andy

    Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection, 2018, Nikolich

    Obviously based on results from mice, so take any claims with a pinch of salt. Paywalled at http://www.pnas.org/content/early/2018/06/26/1719451115 Article about the study https://uanews.arizona.edu/story/virus-may-boost-not-weaken-our-immune-systems
  9. Andy

    ME Association Ramsay Research Fund invests in new study with ME/CFS Biobank to examine dysfunctional immune system and energy metabolism

    http://www.meassociation.org.uk/2018/05/me-association-ramsay-research-fund-invests-in-new-study-with-me-cfs-biobank-to-examine-dysfunctional-immune-system-and-energy-metabolism-15-may-2018/
  10. adreno

    Successful treatment of POTS and MCAS using LDN, immunoglobulin and antibiotics

    Abstract A patient with severe postural orthostatic tachycardia syndrome (POTS) and mast cell activation syndrome (MCAS) received immunotherapy with low-dose naltrexone (LDN) and intravenous immunoglobulin (IVIg) and antibiotic therapy for small intestinal bacterial overgrowth (SIBO). A dramatic...
    • adreno
    • Thread
    • 2018 immunology ivig low-dose naltrexone mcas me/cfs paper pots t-cells treatment
    • Replies: 2
    • Forum: ME/CFS research
  11. Webdog

    Cross-sectional analysis of CD8 T cell immunity to human herpesvirus 6B

    https://doi.org/10.1371/journal.ppat.1006991 There is also a separate thread on a news article covering related research: Note that the news article says "Chronic Fatigue Syndrome", while the actual paper says "chronic fatigue".
    • Webdog
    • Thread
    • 2018 hhv-6 immunology larissa martin me/cfs paper t-cells
    • Replies: 0
    • Forum: ME/CFS research
  12. Indigophoton

    Association of T and NK cell phenotype with the diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Rivas et al, 2018

    The paper has been provisionally accepted by Frontiers in Immunology, and the full text is due to be published soon. https://www.frontiersin.org/articles/10.3389/fimmu.2018.01028/abstract
  13. Andy

    Nature News and Views: Killer T cells show their kinder side

    https://www.nature.com/articles/d41586-018-03510-z
  14. Lidia

    Advice on these T-cell subsets

    Hi, is anyone able to comment on these T-cell subset results please? Patient is 11yo, first blood was taken 6 weeks after an exacerbation of symptoms (head lice/histamine) but before PENE, second blood was taken 3 days after taking an antihistamine. Is there anything at all here of note? Are...
  15. Andy

    Genome - Epigenome Interactions Associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2017, McGowan et al

    Full text pre-print in PDF form - https://www.biorxiv.org/content/biorxiv/early/2017/12/22/237958.full.pdf
    • Andy
    • Thread
    • 2017 epigenomics genomics mcgowan me/cfs paper t-cells
    • Replies: 1
    • Forum: ME/CFS research
  16. Andy

    A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis, 2017, McCoy et al

    Paywalled at http://www.cell.com/cell/fulltext/S0092-8674(17)31116-9 Article based on this study. http://www.gutmicrobiotaforhealth.com/en/study-reveals-new-connection-gut-microbiota-autoimmune-disorders/
  17. Dolphin

    Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires Nuray Aslan et al 2017

    http://mbio.asm.org/content/8/6/e01841-17 Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires Nuray Aslan a, Levi B. Watkin a, Anna Gil a, Rabinarayan Mishra a, Fransenio G. Clarka,d, Raymond M. Welsh a, Dario Ghersi b, Katherine...
  18. Sasha

    Scheibenbogen et al.: Immunometabolism of T cells and monocytes in ME/CFS (grant)

    Another Solve grantee: http://solvecfs.org/2017-ramsay-award-program-team-4/
    • Sasha
    • Thread
    • monocytes scheibenbogen solve mecfs initiative t-cells
    • Replies: 1
    • Forum: ME/CFS research
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